Apoptotic execution phase

Stable Identifier
R-HSA-75153
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Apoptotic execution phase
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In the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucleus and other organelles, DNA fragmentation, chromatin condensation, cell shrinkage and cell detachment and membrane blebbing (reviewed in Fischer et al., 2003).
Literature References
PubMed ID Title Journal Year
12655297 Many cuts to ruin: a comprehensive update of caspase substrates

Janicke, RU, Schulze-Osthoff, K, Fischer, U

Cell Death Differ 2003
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
execution phase of apoptosis (0097194)
Orthologous Events
Apoptotic execution phase (Bos taurus)
Apoptotic execution phase (Caenorhabditis elegans)
Apoptotic execution phase (Canis familiaris)
Apoptotic execution phase (Danio rerio)
Apoptotic execution phase (Dictyostelium discoideum)
Apoptotic execution phase (Drosophila melanogaster)
Apoptotic execution phase (Gallus gallus)
Apoptotic execution phase (Mus musculus)
Apoptotic execution phase (Plasmodium falciparum)
Apoptotic execution phase (Rattus norvegicus)
Apoptotic execution phase (Saccharomyces cerevisiae)
Apoptotic execution phase (Schizosaccharomyces pombe)
Apoptotic execution phase (Sus scrofa)
Apoptotic execution phase (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Alnemri, E  (2004-02-17)
Reviewed
Ranganathan, S  (2007-11-23)
Created
Tschopp, J  (2004-01-28)
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