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Regulation of RAS by GAPs
Stable Identifier
R-HSA-5658442
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Regulation of RAS by GAPs (Homo sapiens)
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The intrinsic GTPase activity of RAS proteins is stimulated by the GAP proteins, of which there are at least 10 in the human genome (reviewed in King et al, 2013).
Literature References
PubMed ID
Title
Journal
Year
23443682
Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis
Lapinski, PE
,
Lubeck, BA
,
King, PD
Sci Signal
2013
Participants
Events
RAS GAPs bind RAS:GTP
(Homo sapiens)
RAS GAPs stimulate RAS GTPase activity
(Homo sapiens)
SPRED dimer binds NF1
(Homo sapiens)
KBTBD7:CUL3:RBX1 ubiquitinates NF1
(Homo sapiens)
NF1 is degraded by the proteasome
(Homo sapiens)
Participates
as an event of
RAF/MAP kinase cascade (Homo sapiens)
Orthologous Events
Regulation of RAS by GAPs (Canis familiaris)
Regulation of RAS by GAPs (Dictyostelium discoideum)
Regulation of RAS by GAPs (Drosophila melanogaster)
Regulation of RAS by GAPs (Gallus gallus)
Regulation of RAS by GAPs (Mus musculus)
Regulation of RAS by GAPs (Rattus norvegicus)
Regulation of RAS by GAPs (Sus scrofa)
Authored
Rothfels, K (2014-12-18)
Reviewed
Roskoski, R Jr (2015-04-29)
Created
Rothfels, K (2014-12-18)
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