Abstract
The ligand gated ion channels (LGICs) are ionotropic receptors to neurotransmitters. Their physiological effect is carried out by the opening of an ionic channel upon binding of a particular neurotransmitter. These LGICs constitute superfamilies of receptors formed by homologous subunits. A database has been developed to handle the growing wealth of cloned subunits. This database contains nucleic acid sequences, protein sequences, as well as multiple sequence alignments and phylogenetic studies. This database is accessible via the worldwide web (http://www.pasteur.fr/units/neubiomol/LGIC.h tml), where it is continuously updated. A downloadable version is also available [currently v0.1 (98.06)].
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Databases, Factual*
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Information Storage and Retrieval
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Internet
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Ion Channel Gating
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Ion Channels / chemistry*
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Ion Channels / genetics*
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Ion Channels / metabolism
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Ligands
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Multigene Family / genetics
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Neurotransmitter Agents / metabolism
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Phylogeny
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Receptors, GABA / chemistry
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Receptors, GABA / genetics
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Receptors, GABA / metabolism
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Receptors, Glutamate / chemistry
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Receptors, Glutamate / genetics
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Receptors, Glutamate / metabolism
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Receptors, Nicotinic / chemistry
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Receptors, Nicotinic / genetics
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Receptors, Nicotinic / metabolism
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Receptors, Purinergic P2 / chemistry
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Receptors, Purinergic P2 / genetics
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Receptors, Purinergic P2 / metabolism
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Receptors, Serotonin / chemistry
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Receptors, Serotonin / genetics
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Receptors, Serotonin / metabolism
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Sequence Alignment
Substances
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Ion Channels
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Ligands
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Neurotransmitter Agents
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Receptors, GABA
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Receptors, Glutamate
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Receptors, Nicotinic
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Receptors, Purinergic P2
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Receptors, Serotonin