The Pharmacogene Variation (PharmVar) Consortium: Incorporation of the Human Cytochrome P450 (CYP) Allele Nomenclature Database

Andrea Gaedigk; Magnus Ingelman-Sundberg; Neil A Miller; J Steven Leeder; Michelle Whirl-Carrillo; Teri E Klein; PharmVar Steering Committee

doi:10.1002/cpt.910

The Pharmacogene Variation (PharmVar) Consortium: Incorporation of the Human Cytochrome P450 (CYP) Allele Nomenclature Database

Clin Pharmacol Ther. 2018 Mar;103(3):399-401. doi: 10.1002/cpt.910. Epub 2017 Nov 14.

Authors

Andrea Gaedigk¹, Magnus Ingelman-Sundberg², Neil A Miller³, J Steven Leeder¹, Michelle Whirl-Carrillo⁴, Teri E Klein⁴; PharmVar Steering Committee

Affiliations

¹ Division of Clinical Pharmacology, Toxicology & Therapeutic Innovation, Children's Mercy Kansas City, and School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA.
² Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
³ Center for Pediatric Genomic Medicine, Children's Mercy Kansas City, Kansas City, Missouri, USA.
⁴ Department of Genetics, Stanford University, Stanford, California, USA.

PMID: 29134625
PMCID: PMC5836850
DOI: 10.1002/cpt.910

Abstract

The Human Cytochrome P450 (CYP) Allele Nomenclature Database, a critical resource for the pharmacogenetics and genomics communities, has transitioned to the Pharmacogene Variation (PharmVar) Consortium. In this report we provide a summary of the current database, provide an overview of the PharmVar consortium, and highlight the PharmVar database which will serve as the new home for pharmacogene nomenclature.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Alleles*
Cytochrome P-450 Enzyme System / drug effects
Cytochrome P-450 Enzyme System / genetics*
Databases, Factual
Databases, Genetic*
Genetic Variation
Humans
Pharmacogenetics*
Terminology as Topic*

Substances

Cytochrome P-450 Enzyme System

Abstract

Publication types

MeSH terms

Substances

Grants and funding