The neXtProt knowledgebase on human proteins: current status

Pascale Gaudet; Pierre-André Michel; Monique Zahn-Zabal; Isabelle Cusin; Paula D Duek; Olivier Evalet; Alain Gateau; Anne Gleizes; Mario Pereira; Daniel Teixeira; Ying Zhang; Lydie Lane; Amos Bairoch

doi:10.1093/nar/gku1178

The neXtProt knowledgebase on human proteins: current status

Nucleic Acids Res. 2015 Jan;43(Database issue):D764-70. doi: 10.1093/nar/gku1178.

Affiliations

¹ CALIPHO group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland, 1211 Department of Human Protein Sciences, Faculty of Medicine, University of Geneva, Geneva, Switzerland, 1211 pascale.gaudet@isb-sib.ch.
² CALIPHO group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland, 1211.
³ CALIPHO group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland, 1211 Department of Human Protein Sciences, Faculty of Medicine, University of Geneva, Geneva, Switzerland, 1211.

Abstract

neXtProt (http://www.nextprot.org) is a human protein-centric knowledgebase developed at the SIB Swiss Institute of Bioinformatics. Focused solely on human proteins, neXtProt aims to provide a state of the art resource for the representation of human biology by capturing a wide range of data, precise annotations, fully traceable data provenance and a web interface which enables researchers to find and view information in a comprehensive manner. Since the introductory neXtProt publication, significant advances have been made on three main aspects: the representation of proteomics data, an extended representation of human variants and the development of an advanced search capability built around semantic technologies. These changes are presented in the current neXtProt update.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line
Databases, Protein*
Disease / genetics
Genetic Variation*
Humans
Internet
Proteins / genetics*
Proteome
Proteomics*

Substances

Proteins
Proteome