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PRO ID
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| PRO name | papain-like proteinase nsp3 (SARS-CoV-2) |
| Synonyms | | PRO-Short-label: | EXACT: | rep/Clv:nsp3 (SARS2) | | PRO-proteoform-std: | EXACT: | UniProtKB:P0DTC1, 819-2763 | UniProtKB:P0DTD1, 819-2763 | | Other: | EXACT: | main proteinase (SARS-CoV-2) | non-structural protein 3 (SARS-CoV-2) | nsp3 (SARS-CoV-2) | PLpro (SARS-CoV-2) | PRO_0000449621 | PRO_0000449637 | | RELATED: | PL2-PRO (SARS-CoV-2) |
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| Definition | "A rep gene proteolytic cleavage product (SARS-CoV-2) that is the central portion produced by the autocatalytic action of PL-PRO proteinase (nsp3) when it cleaves the precursor rep gene translation product (SARS-CoV-2) between residues 818-819 and 2763-2764." [GenPept:YP_009725299, PRO:DAN, UniProtKB:P0DTC1, UniProtKB:P0DTD1] |
| Comment | Note: 1945 aa protein. Unlike some other coronaviruses, SARS coronaviruses only encode a single papain-like proteinase, PLpro. [PMID:15564471]. |
| PRO Category | organism-modification |
| Parent | PR:000050281 rep gene proteolytic cleavage product (SARS-CoV-2)
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| Taxon | NCBITaxon:2697049 Severe acute respiratory syndrome coronavirus 2 |
Term Hierarchy
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