CTRP Terminology
CTRP Agent Terminology
NCI Drug Dictionary Terminology
Antiviral Agent
Valacyclovir
124832-26-4
257236
257236
257236
A substance that is being studied in the prevention of fungal, bacterial, and viral infections in patients undergoing donor stem cell transplantation with cells that are infected with cytomegalovirus. It belongs to the family of drugs called antivirals.
C0249458
C13H20N6O4
C28235
CHEBI:35854
CTRP
FDA
L-Valine ester with 9-((2-hydroxyethoxy)methyl)guanine
MZ1IW7Q79D
Organic Chemical
Pharmacologic Substance
The hydrochloride salt of the L-valyl ester of the antiviral drug acyclovir. Orally administered, valacyclovir is rapidly converted to acyclovir which inhibits viral DNA replication after further conversion to the nucleotide analog acyclovir triphosphate by viral thymidine kinase, cellular guanyl cyclase, and a number of other cellular enzymes. Acyclovir triphosphate competitively inhibits viral DNA polymerase; incorporates into and terminates the growing viral DNA chain; and inactivates viral DNA polymerase. The greater antiviral activity of acyclovir against herpes simplex virus (HSV) compared with varicella-zoster virus (VZV) is due to its more efficient phosphorylation by HSV thymidine kinase.
VALACYCLOVIR
ValACV
Valaciclovir
Valacyclovir
Valacyclovir
Valacyclovir
Valacyclovir
Zelitrex
valacyclovir
Valacyclovir Hydrochloride
DNA Polymerase Inhibitor
FDA Established Names and Unique Ingredient Identifier Codes Terminology