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LPGAT1 lysophosphatidylglycerol acyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 9926, updated on 7-Apr-2024

Summary

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Official Symbol
LPGAT1provided by HGNC
Official Full Name
lysophosphatidylglycerol acyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:28985
See related
Ensembl:ENSG00000123684 MIM:610473; AllianceGenome:HGNC:28985
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NET8; FAM34A; LPLAT7; FAM34A1
Summary
This gene encodes a member of the lysophospholipid acyltransferase family. The encoded protein catalyzes the reacylation of lysophosphatidylglycerol to phosphatidylglycerol, a membrane phospholipid that is an important precursor for the synthesis of cardiolipin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in small intestine (RPKM 15.0), thyroid (RPKM 14.6) and 25 other tissues See more
Orthologs
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Genomic context

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See LPGAT1 in Genome Data Viewer
Location:
1q32.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (211743457..211830763, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (210989592..211076889, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (211916799..212004105, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 55 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:211868601-211869100 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1791 Neighboring gene NEK2 divergent transcript Neighboring gene NANOG hESC enhancer GRCh37_chr1:211877490-211877991 Neighboring gene uncharacterized LOC105372904 Neighboring gene Sharpr-MPRA regulatory region 10839 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:211908669-211909168 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_3231 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_3241 Neighboring gene RNA, 7SL, cytoplasmic 344, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1792 Neighboring gene LPGAT1 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:212028571-212028750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2490 Neighboring gene Sharpr-MPRA regulatory region 10612 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_3305 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:212101684-212102185 Neighboring gene peptidyl-prolyl cis-trans isomerase NIMA-interacting 4-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2492 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2493 Neighboring gene NANOG hESC enhancer GRCh37_chr1:212120901-212121513 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:212141376-212141876 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:212141877-212142377 Neighboring gene integrator complex subunit 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2494 Neighboring gene small nucleolar RNA SNORA26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Upregulation of LPGAT1 Enhances Lung Adenocarcinoma Proliferation. Gong H, et al. Front Biosci (Landmark Ed), 2023 May 11. PMID 37258473
  2. Evidence for a role of LPGAT1 in influencing BMI and percent body fat in Native Americans. Traurig MT, et al. Obesity (Silver Spring), 2013 Jan. PMID 23505186, Free PMC Article
  3. Identification and characterization of a gene encoding human LPGAT1, an endoplasmic reticulum-associated lysophosphatidylglycerol acyltransferase. Yang Y, et al. J Biol Chem, 2004 Dec 31. PMID 15485873
  4. An antigen recognized by autologous CTLs on a human bladder carcinoma. Guéguen M, et al. J Immunol, 1998 Jun 15. PMID 9637538
  5. Identification and characterization of LPLAT7 as an sn-1-specific lysophospholipid acyltransferase. Kawana H, et al. J Lipid Res, 2022 Oct. PMID 36049524, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulation of LPGAT1 Enhances Lung Adenocarcinoma Proliferation.
    Title: Upregulation of LPGAT1 Enhances Lung Adenocarcinoma Proliferation.
  2. LPGAT1 is a novel gene that influences BMI in Native Americans.
    Title: Evidence for a role of LPGAT1 in influencing BMI and percent body fat in Native Americans.
  3. human LPGAT1 is an endoplasmic reticulum-associated lysophosphatidylglycerol acyltransferase
    Title: Identification and characterization of a gene encoding human LPGAT1, an endoplasmic reticulum-associated lysophosphatidylglycerol acyltransferase.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity TAS
Traceable Author Statement
more info
  
enables 2-acylglycerol O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables 2-acylglycerol-3-phosphate O-acyltransferase activity TAS
Traceable Author Statement
more info
  
enables 2-acylglycerophosphocholine O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysophosphatidylethanolamine acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables lysophospholipid acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lysophospholipid acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphatidylethanolamine acyl-chain remodeling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidylglycerol acyl-chain remodeling TAS
Traceable Author Statement
more info
  
involved_in phosphatidylinositol acyl-chain remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in triglyceride biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in membrane HDA PubMed 

General protein information

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Preferred Names
acyl-CoA:lysophosphatidylglycerol acyltransferase 1
Names
2-acylglycerophosphocholine O-acyltransferase
acyl-CoA:monoacylglycerol acyltransferase LPGAT1
family with sequence similarity 34, member A
lysophospholipid acyltransferase 7
stearoyl-CoA:1-lyso-2-acyl-PE acyltransferase
NP_001307737.1
NP_001362770.1
NP_001362771.1
NP_001362773.1
NP_001362774.1
NP_055688.1
XP_011508531.1
XP_047292088.1
XP_047292091.1
XP_047292096.1
XP_054195920.1
XP_054195921.1
XP_054195922.1
XP_054195923.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320808.2 → NP_001307737.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC096637, AI264005, AL445488, BC034621, BP369253
    Consensus CDS
    CCDS31018.1
    UniProtKB/Swiss-Prot
    Q53YL2, Q92604
    Related
    ENSP00000355963.1, ENST00000366996.1
    Conserved Domains (2) summary
    cd07990
    Location:69 → 285
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:274 → 343
    Acyltransf_C; Acyltransferase C-terminus

  2. NM_001375841.1 → NP_001362770.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC096637, AL445488
    Consensus CDS
    CCDS31018.1
    UniProtKB/Swiss-Prot
    Q53YL2, Q92604
    Conserved Domains (2) summary
    cd07990
    Location:69 → 285
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:274 → 343
    Acyltransf_C; Acyltransferase C-terminus

  3. NM_001375842.1 → NP_001362771.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC096637, AL445488
    Consensus CDS
    CCDS31018.1
    UniProtKB/Swiss-Prot
    Q53YL2, Q92604
    Conserved Domains (2) summary
    cd07990
    Location:69 → 285
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:274 → 343
    Acyltransf_C; Acyltransferase C-terminus

  4. NM_001375844.1 → NP_001362773.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC096637, AL445488
    Conserved Domains (2) summary
    cd07990
    Location:102 → 318
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:307 → 376
    Acyltransf_C; Acyltransferase C-terminus

  5. NM_001375845.1 → NP_001362774.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC096637, AL445488
    Conserved Domains (2) summary
    cd07990
    Location:102 → 318
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:307 → 376
    Acyltransf_C; Acyltransferase C-terminus

  6. NM_014873.3 → NP_055688.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_055688.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC096637, AI264005, D86960
    Consensus CDS
    CCDS31018.1
    UniProtKB/Swiss-Prot
    Q53YL2, Q92604
    Related
    ENSP00000355964.4, ENST00000366997.9
    Conserved Domains (2) summary
    cd07990
    Location:69 → 285
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:274 → 343
    Acyltransf_C; Acyltransferase C-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    211743457..211830763 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436132.1 → XP_047292088.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X1

  2. XM_011510229.4 → XP_011508531.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X3

    See identical proteins and their annotated locations for XP_011508531.1

    UniProtKB/Swiss-Prot
    Q53YL2, Q92604
    Conserved Domains (2) summary
    cd07990
    Location:69 → 285
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:274 → 343
    Acyltransf_C; Acyltransferase C-terminus

  3. XM_047436140.1 → XP_047292096.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X3

    UniProtKB/Swiss-Prot
    Q53YL2, Q92604

  4. XM_047436135.1 → XP_047292091.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    210989592..211076889 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339945.1 → XP_054195920.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X1

  2. XM_054339947.1 → XP_054195922.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X3

    UniProtKB/Swiss-Prot
    Q53YL2, Q92604

  3. XM_054339948.1 → XP_054195923.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X3

    UniProtKB/Swiss-Prot
    Q53YL2, Q92604

  4. XM_054339946.1 → XP_054195921.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q92604.1 GenPept UniProtKB/Swiss-Prot:Q92604

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