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Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 [ Mus musculus (house mouse) ]

Gene ID: 98432, updated on 13-Jan-2025

Summary

Official Symbol
Phlpp1provided by MGI
Official Full Name
PH domain and leucine rich repeat protein phosphatase 1provided by MGI
Primary source
MGI:MGI:2138327
See related
Ensembl:ENSMUSG00000044340 AllianceGenome:MGI:2138327
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SCOP; Phlpp; Plekhe1; mKIAA0606
Summary
Predicted to enable protein serine/threonine phosphatase activity. Involved in regulation of T cell anergy. Acts upstream of or within entrainment of circadian clock. Predicted to be located in nuclear membrane; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in ventricular layer. Orthologous to human PHLPP1 (PH domain and leucine rich repeat protein phosphatase 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in testis adult (RPKM 28.1), cerebellum adult (RPKM 15.2) and 25 other tissues See more
Orthologs
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Genomic context

See Phlpp1 in Genome Data Viewer
Location:
1 E2.1; 1 49.76 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (106099599..106321975)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (106171869..106394245)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01848 Neighboring gene predicted gene, 26509 Neighboring gene STARR-seq mESC enhancer starr_01850 Neighboring gene STARR-positive B cell enhancer ABC_E9059 Neighboring gene STARR-positive B cell enhancer ABC_E2005 Neighboring gene predicted gene, 20753 Neighboring gene STARR-positive B cell enhancer mm9_chr1:108128082-108128383 Neighboring gene STARR-positive B cell enhancer ABC_E1226 Neighboring gene STARR-positive B cell enhancer ABC_E7737 Neighboring gene STARR-positive B cell enhancer mm9_chr1:108248841-108249142 Neighboring gene STARR-positive B cell enhancer ABC_E10026 Neighboring gene STARR-positive B cell enhancer ABC_E11081 Neighboring gene STARR-seq mESC enhancer starr_01857 Neighboring gene predicted gene 6651 Neighboring gene STARR-seq mESC enhancer starr_01858 Neighboring gene predicted gene, 41928

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in apoptotic process  
involved_in chromatin remodeling  
acts_upstream_of_or_within entrainment of circadian clock PubMed 
involved_in intracellular signal transduction  
involved_in negative regulation of ERK1 and ERK2 cascade  
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in negative regulation of protein kinase C signaling  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in positive regulation of protein kinase C signaling  
involved_in regulation of JNK cascade  
involved_in regulation of JNK cascade  
involved_in regulation of MAPK cascade  
involved_in regulation of T cell anergy PubMed 
involved_in regulation of apoptotic process  
involved_in regulation of apoptotic process  
involved_in regulation of p38MAPK cascade  
involved_in regulation of p38MAPK cascade  
involved_in regulation of protein phosphorylation  
involved_in regulation of transcription by RNA polymerase II  
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytoplasm  
located_in membrane  
located_in nuclear membrane  
located_in nucleoplasm  
located_in nucleus  
located_in plasma membrane  

General protein information

Preferred Names
PH domain leucine-rich repeat-containing protein phosphatase 1
Names
PH domain-containing family E member 1
pleckstrin homology domain containing, family E (with leucine rich repeats) member 1
pleckstrin homology domain-containing family E member 1
suprachiasmatic nucleus circadian oscillatory protein
NP_598582.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133821.3NP_598582.3  PH domain leucine-rich repeat-containing protein phosphatase 1

    See identical proteins and their annotated locations for NP_598582.3

    Status: VALIDATED

    Source sequence(s)
    AC124710, BC059254, CF535385, CN525246
    Consensus CDS
    CCDS48337.1
    UniProtKB/Swiss-Prot
    Q6PCN0, Q8CHE4, Q8QZU8, Q8R5E5, Q99KL6
    Related
    ENSMUSP00000056530.7, ENSMUST00000061047.7
    Conserved Domains (6) summary
    smart00332
    Location:11241376
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain
    cd00116
    Location:581885
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd13322
    Location:491587
    PH_PHLPP-like; PH domain leucine-rich repeat protein phosphatase family Pleckstrin homology-like domain
    sd00033
    Location:789809
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00169
    Location:511592
    PH; PH domain
    pfam13855
    Location:594659
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    106099599..106321975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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