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Wwtr1 WW domain containing transcription regulator 1 [ Mus musculus (house mouse) ]

Gene ID: 97064, updated on 16-Apr-2024

Summary

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Official Symbol
Wwtr1provided by MGI
Official Full Name
WW domain containing transcription regulator 1provided by MGI
Primary source
MGI:MGI:1917649
See related
Ensembl:ENSMUSG00000027803 AllianceGenome:MGI:1917649
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Taz; 2310058J06Rik; 2610021I22Rik
Summary
This gene encodes a binding protein of the 14-3-3 family of proteins that regulate cell cycle progression, differentiation and apoptosis. The encoded protein is a transcriptional co-activator that binds to the PPXY motif present on transcription factors. The gene product contains a WW domain and, in the C-terminus, a conserved PDZ-binding motif. This gene is distinct from the gene encoding tafazzin. Both genes share the gene symbol Taz. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]
Annotation information
Note: Wwtr1 (Gene ID: 97064) and Taz (Gene ID: 66826) loci share the Taz symbol/alias in common. [08 Feb 2019]
Expression
Broad expression in bladder adult (RPKM 25.1), lung adult (RPKM 24.7) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Wwtr1 in Genome Data Viewer
Location:
3 D; 3 27.74 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (57363065..57483331, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (57455644..57575910, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52659 Neighboring gene transmembrane 4 superfamily member 4 Neighboring gene STARR-seq mESC enhancer starr_07732 Neighboring gene NEDD8-conjugating enzyme UBE2F pseudogene Neighboring gene STARR-seq mESC enhancer starr_07733 Neighboring gene STARR-seq mESC enhancer starr_07736 Neighboring gene predicted gene, 26671 Neighboring gene microRNA 6377 Neighboring gene predicted gene, 46805 Neighboring gene COMM domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CD133-Src-TAZ signaling stimulates ductal fibrosis following DDC diet-induced liver injury. Oh HT, et al. J Cell Physiol, 2022 Dec. PMID 36250997
  2. Reduced expression of TAZ inhibits primary cilium formation in renal glomeruli. Jun JH, et al. Exp Mol Med, 2022 Feb. PMID 35177808, Free PMC Article
  3. TAZ links exercise to mitochondrial biogenesis via mitochondrial transcription factor A. Hwang JH, et al. Nat Commun, 2022 Feb 3. PMID 35115527, Free PMC Article
  4. TAZ inhibits acinar cell differentiation but promotes immature ductal cell proliferation in adult mouse salivary glands. Miyachi Y, et al. Genes Cells, 2021 Sep. PMID 34142411
  5. Tubular transcriptional co-activator with PDZ-binding motif protects against ischemic acute kidney injury. Wu CL, et al. Clin Sci (Lond), 2020 Jul 17. PMID 32558891

See all (317) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Targeting YAP/TAZ mechanosignaling to ameliorate stiffness-induced Schlemm's canal cell pathobiology.
    Title: Targeting YAP/TAZ mechanosignaling to ameliorate stiffness-induced Schlemm's canal cell pathobiology.
  2. Wnt16 Promotes Vascular Smooth Muscle Contractile Phenotype and Function via Taz (Wwtr1) Activation in Male LDLR-/- Mice.
    Title: Wnt16 Promotes Vascular Smooth Muscle Contractile Phenotype and Function via Taz (Wwtr1) Activation in Male LDLR-/- Mice.
  3. TAZ stimulates exercise-induced muscle satellite cell activation via Pard3-p38 MAPK-TAZ signalling axis.
    Title: TAZ stimulates exercise-induced muscle satellite cell activation via Pard3-p38 MAPK-TAZ signalling axis.
  4. TAZ facilitates breast tumor growth by promoting an immune-suppressive tumor microenvironment.
    Title: TAZ facilitates breast tumor growth by promoting an immune-suppressive tumor microenvironment.
  5. Genetic interactions between polycystin-1 and Wwtr1 in osteoblasts define a novel mechanosensing mechanism regulating bone formation in mice.
    Title: Genetic interactions between polycystin-1 and Wwtr1 in osteoblasts define a novel mechanosensing mechanism regulating bone formation in mice.
  6. Regulation of follicular activation signaling pathways by in vitro inhibition of YAP/TAZ activity in mouse ovaries.
    Title: Regulation of follicular activation signaling pathways by in vitro inhibition of YAP/TAZ activity in mouse ovaries.
  7. Vascular smooth muscle-specific YAP/TAZ deletion triggers aneurysm development in mouse aorta.
    Title: Vascular smooth muscle-specific YAP/TAZ deletion triggers aneurysm development in mouse aorta.
  8. Loss of TAZ after YAP deletion severely impairs foregut development and worsens cholestatic hepatocellular injury.
    Title: Loss of TAZ after YAP deletion severely impairs foregut development and worsens cholestatic hepatocellular injury.
  9. Emerging Roles of YAP/TAZ in Tooth and Surrounding: from Development to Regeneration.
    Title: Emerging Roles of YAP/TAZ in Tooth and Surrounding: from Development to Regeneration.
  10. A YAP/TAZ-CD54 axis is required for CXCR2-CD44- tumor-specific neutrophils to suppress gastric cancer.
    Title: A YAP/TAZ-CD54 axis is required for CXCR2-CD44- tumor-specific neutrophils to suppress gastric cancer.
Submit: New GeneRIF Correction See all GeneRIFs (143)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (13)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glomerulus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heart process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hippo signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within kidney morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mesenchymal cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of fat cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within osteoblast differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of metanephric nephron tubule epithelial cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in stem cell division ISO
Inferred from Sequence Orthology
more info
  
involved_in tissue homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
WW domain-containing transcription regulator protein 1
Names
transcriptional coactivator with PDZ-binding motif

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168281.1 → NP_001161753.1  WW domain-containing transcription regulator protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001161753.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
    Source sequence(s)
    AK009983, AK142299, AK142720, AV026487, AW457051
    Consensus CDS
    CCDS50912.1
    UniProtKB/Swiss-Prot
    Q9EPK5
    Related
    ENSMUSP00000113040.2, ENSMUST00000120977.2
    Conserved Domains (1) summary
    smart00456
    Location:182 → 213
    WW; Domain with 2 conserved Trp (W) residues

  2. NM_133784.3 → NP_598545.2  WW domain-containing transcription regulator protein 1 isoform 2

    See identical proteins and their annotated locations for NP_598545.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK009983, AK142299, AK142720, AV026487, AW457051, BY145519
    Consensus CDS
    CCDS38434.1
    UniProtKB/Swiss-Prot
    Q3UQ69, Q3UQM0, Q99KI4, Q9EPK5
    Related
    ENSMUSP00000029380.8, ENSMUST00000029380.14
    Conserved Domains (1) summary
    smart00456
    Location:125 → 156
    WW; Domain with 2 conserved Trp (W) residues

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    57363065..57483331 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EPK5.2 GenPept UniProtKB/Swiss-Prot:Q9EPK5

Gene LinkOut

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