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PB2 polymerase PB2 [ Influenza A virus (A/Puerto Rico/8/1934(H1N1)) ]

Gene ID: 956536, updated on 29-Nov-2023

Summary

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Gene symbol
PB2
Gene description
polymerase PB2
Locus tag
FLUAVs1gp1
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Influenza A virus (A/Puerto Rico/8/1934(H1N1)) (strain: A/Puerto Rico/8/1934, serotype: H1N1)
Lineage
Viruses; ssRNA viruses; ssRNA negative-strand viruses; Orthomyxoviridae; Influenzavirus A
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Genomic context

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Location:
segment: 1
Sequence:
NC_002023.1 (28..2307)

NC_002023.1Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002023.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Virtual Screening and Molecular Dynamics Simulation Study of Influenza Polymerase PB2 Inhibitors. Zong K, et al. Molecules, 2021 Nov 17. PMID 34834044, Free PMC Article
  2. Comprehensive Profiling of Mutations to Influenza Virus PB2 That Confer Resistance to the Cap-Binding Inhibitor Pimodivir. Soh YQS, et al. Viruses, 2021 Jun 22. PMID 34206520, Free PMC Article
  3. Nonproteolytic K29-Linked Ubiquitination of the PB2 Replication Protein of Influenza A Viruses by Proviral Cullin 4-Based E3 Ligases. Karim M, et al. mBio, 2020 Apr 7. PMID 32265326, Free PMC Article
  4. Rule-based meta-analysis reveals the major role of PB2 in influencing influenza A virus virulence in mice. Ivan FX, et al. BMC Genomics, 2019 Dec 24. PMID 31874643, Free PMC Article
  5. Substitution of D701N in the PB2 protein could enhance the viral replication and pathogenicity of Eurasian avian-like H1N1 swine influenza viruses. Liu S, et al. Emerg Microbes Infect, 2018 May 2. PMID 29717109, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protein arginine methyltransferase 5 mediates arginine symmetric dimethylation of influenza A virus PB2 and supports viral replication.
    Title: Protein arginine methyltransferase 5 mediates arginine symmetric dimethylation of influenza A virus PB2 and supports viral replication.
  2. Virtual Screening and Molecular Dynamics Simulation Study of Influenza Polymerase PB2 Inhibitors.
    Title: Virtual Screening and Molecular Dynamics Simulation Study of Influenza Polymerase PB2 Inhibitors.
  3. Comprehensive Profiling of Mutations to Influenza Virus PB2 That Confer Resistance to the Cap-Binding Inhibitor Pimodivir.
    Title: Comprehensive Profiling of Mutations to Influenza Virus PB2 That Confer Resistance to the Cap-Binding Inhibitor Pimodivir.
  4. A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity.
    Title: A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity.
  5. Nonproteolytic K29-Linked Ubiquitination of the PB2 Replication Protein of Influenza A Viruses by Proviral Cullin 4-Based E3 Ligases.
    Title: Nonproteolytic K29-Linked Ubiquitination of the PB2 Replication Protein of Influenza A Viruses by Proviral Cullin 4-Based E3 Ligases.
  6. TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2.
    Title: TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2.
  7. The study confirmed the polygenic nature of Influenza A virus virulence, with several sites in PB2 playing more dominant role (meta-analysis).
    Title: Rule-based meta-analysis reveals the major role of PB2 in influencing influenza A virus virulence in mice.
  8. The C-terminal portion of ANP32A and the middle domains (residues 307-534) of PB2 were required for PB2-ANP32A interaction.
    Title: The interaction of cellular protein ANP32A with influenza A virus polymerase component PB2 promotes vRNA synthesis.
  9. Viral polymerase activity, viral replication, and pathogenicity in mice were enhanced due to the substitution of D701N in the PB2 protein.
    Title: Substitution of D701N in the PB2 protein could enhance the viral replication and pathogenicity of Eurasian avian-like H1N1 swine influenza viruses.
  10. Two miRNAs, miR-584-5p and miR-1249, that matched with the PB2 binding sequence, dramatically down-regulated PB2 expression, and inhibited replication of H5N1 and H1N1 influenza A virus strains in A549 cells.
    Title: The highly pathogenic H5N1 influenza A virus down-regulated several cellular MicroRNAs which target viral genome.
Submit: New GeneRIF Correction See all GeneRIFs (37)

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
polymerase PB2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002023.1 Reference assembly

    Range
    28..2307
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_040987.1 polymerase PB2 [Influenza A virus (A/Puerto Rico/8/1934(H1N1))]

    See identical proteins and their annotated locations for NP_040987.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2R4QPN2, D3J174, F5CGP0, M9V1B6
    Conserved Domains (1) summary
    pfam00604
    Location:1 → 757
    Flu_PB2; Influenza RNA-dependent RNA polymerase subunit PB2
Nucleotide Protein
Heading Accession and Version

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