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PB1 polymerase PB1 [ Influenza A virus (A/Puerto Rico/8/1934(H1N1)) ]

Gene ID: 956534, updated on 18-Aug-2023

Summary

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Gene symbol
PB1
Gene description
polymerase PB1
Locus tag
FLUAVs2gp1
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Influenza A virus (A/Puerto Rico/8/1934(H1N1)) (strain: A/Puerto Rico/8/1934, serogroup: H1N1)
Lineage
Viruses; ssRNA viruses; ssRNA negative-strand viruses; Orthomyxoviridae; Influenzavirus A
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Genomic context

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Location:
segment: 2
Sequence:
NC_002021.1 (25..2298)

NC_002021.1Genomic Context describing neighboring genes Neighboring gene PB1-F2 protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002021.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Variations outside the conserved motifs of PB1 catalytic active site may affect replication efficiency of the RNP complex of influenza A virus. Waters K, et al. Virology, 2021 Jul. PMID 33887645, Free PMC Article
  2. A PB1 T296R substitution enhance polymerase activity and confer a virulent phenotype to a 2009 pandemic H1N1 influenza virus in mice. Yu Z, et al. Virology, 2015 Dec. PMID 26453960
  3. Impact of the segment-specific region of the 3'-untranslated region of the influenza A virus PB1 segment on protein expression. Ma J, et al. Virus Genes, 2013 Dec. PMID 23949786
  4. Inhibition of influenza A virus replication by RNA interference targeted against the PB1 subunit of the RNA polymerase gene. Li W, et al. Arch Virol, 2011 Nov. PMID 21837415
  5. A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity. Cox A, et al. Viruses, 2020 Oct 31. PMID 33142846, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Variations outside the conserved motifs of PB1 catalytic active site may affect replication efficiency of the RNP complex of influenza A virus.
    Title: Variations outside the conserved motifs of PB1 catalytic active site may affect replication efficiency of the RNP complex of influenza A virus.
  2. Eukaryotic Translation Elongation Factor 1 Delta Inhibits the Nuclear Import of the Nucleoprotein and PA-PB1 Heterodimer of Influenza A Virus.
    Title: Eukaryotic Translation Elongation Factor 1 Delta Inhibits the Nuclear Import of the Nucleoprotein and PA-PB1 Heterodimer of Influenza A Virus.
  3. A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity.
    Title: A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity.
  4. PB1-T296R substitution enhanced viral replication, polymerase activity and virulence.
    Title: A PB1 T296R substitution enhance polymerase activity and confer a virulent phenotype to a 2009 pandemic H1N1 influenza virus in mice.
  5. The ts-mutations in PB1, PB2, and PA genes are mostly involved in the modulation of the humoral immunity, but also have a moderate effect on the cellular adaptive immune response.
    Title: [Effect of Point Mutations in the Polymerase Genes of the Influenza A/PR/8/34 (H1N1) Virus on the Immune Response in a Mouse Model].
  6. The deletion of "UAAA" and "UAAACU" motifs in the PB1-3'-UTR significantly increased the protein expression.
    Title: Impact of the segment-specific region of the 3'-untranslated region of the influenza A virus PB1 segment on protein expression.
  7. Inhibition of PB1 by RNA interference inhibits influenza A virus replication.
    Title: Inhibition of influenza A virus replication by RNA interference targeted against the PB1 subunit of the RNA polymerase gene.
  8. x ray crystallography of essential PB1-PB2 subunit contact of the influenza virus RNA polymerase
    Title: Structural insight into the essential PB1-PB2 subunit contact of the influenza virus RNA polymerase.
  9. the crystal structure of a large fragment of one subunit (PA) of influenza A RNA polymerase bound to a fragment of another subunit (PB1).
    Title: The structural basis for an essential subunit interaction in influenza virus RNA polymerase.
  10. Study identified a novel function of PB1-F2 as an indirect regulator of the influenza virus polymerase activity via its interaction with PB1.
    Title: The proapoptotic influenza A virus protein PB1-F2 regulates viral polymerase activity by interaction with the PB1 protein.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
polymerase PB1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002021.1 Reference assembly

    Range
    25..2298
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_040985.1 polymerase PB1 [Influenza A virus (A/Puerto Rico/8/1934(H1N1))]

    See identical proteins and their annotated locations for NP_040985.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4GXH1, P03431, Q20N30, Q8JUU7
    UniProtKB/TrEMBL
    A0A2R4QPM5, F5CGL9, F5CGN1, F5CGP1, M9UYU3
    Conserved Domains (1) summary
    pfam00602
    Location:1 → 741
    Flu_PB1; Influenza RNA-dependent RNA polymerase subunit PB1
Nucleotide Protein
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