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NP nucleoprotein [ Influenza A virus (A/Puerto Rico/8/1934(H1N1)) ]

Gene ID: 956531, updated on 6-Oct-2023

Summary

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Gene symbol
NP
Gene description
nucleoprotein
Locus tag
FLUAVs5gp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Influenza A virus (A/Puerto Rico/8/1934(H1N1)) (strain: A/Puerto Rico/8/1934(H1N1))
Lineage
Viruses; ssRNA viruses; ssRNA negative-strand viruses; Orthomyxoviridae; Influenzavirus A
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Genomic context

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Location:
segment: 5
Sequence:
NC_002019.1 (46..1542)

NC_002019.1Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002019.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations Conferring Increased Sensitivity to Tripartite Motif 22 Restriction Accumulated Progressively in the Nucleoprotein of Seasonal Influenza A (H1N1) Viruses between 1918 and 2009. Pagani I, et al. mSphere, 2018 Apr 25. PMID 29624498, Free PMC Article
  2. Molecular dynamics studies of the nucleoprotein of influenza A virus: role of the protein flexibility in RNA binding. Tarus B, et al. PLoS One, 2012. PMID 22272272, Free PMC Article
  3. Mutational analysis of conserved amino acids in the influenza A virus nucleoprotein. Li Z, et al. J Virol, 2009 May. PMID 19225007, Free PMC Article
  4. Studies of an influenza A virus temperature-sensitive mutant identify a late role for NP in the formation of infectious virions. Noton SL, et al. J Virol, 2009 Jan. PMID 18987140, Free PMC Article
  5. The structure of the gene encoding the nucleoprotein of human influenza virus A/PR/8/34. Winter G, et al. Virology, 1981 Oct 30. PMID 7292985

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The circRNA circVAMP3 restricts influenza A virus replication by interfering with NP and NS1 proteins.
    Title: The circRNA circVAMP3 restricts influenza A virus replication by interfering with NP and NS1 proteins.
  2. Heterogeneous Ribonucleoprotein A1 (hnRNPA1) Interacts with the Nucleoprotein of the Influenza a Virus and Impedes Virus Replication.
    Title: Heterogeneous Ribonucleoprotein A1 (hnRNPA1) Interacts with the Nucleoprotein of the Influenza a Virus and Impedes Virus Replication.
  3. A human cell polarity protein Lgl2 regulates influenza A virus nucleoprotein exportation from nucleus in MDCK cells.
    Title: A human cell polarity protein Lgl2 regulates influenza A virus nucleoprotein exportation from nucleus in MDCK cells.
  4. Eukaryotic Translation Elongation Factor 1 Delta Inhibits the Nuclear Import of the Nucleoprotein and PA-PB1 Heterodimer of Influenza A Virus.
    Title: Eukaryotic Translation Elongation Factor 1 Delta Inhibits the Nuclear Import of the Nucleoprotein and PA-PB1 Heterodimer of Influenza A Virus.
  5. four arginine residues present in the NP of the 1918 H1N1 pandemic strain and early postpandemic strains were progressively substituted for by lysines between 1918 and 2009, rendering NP more susceptible to TRIM22-mediated ubiquitination
    Title: Mutations Conferring Increased Sensitivity to Tripartite Motif 22 Restriction Accumulated Progressively in the Nucleoprotein of Seasonal Influenza A (H1N1) Viruses between 1918 and 2009.
  6. Taking these observations together, TRIM41 is a constitutively expressed intrinsic influenza A virus restriction factor that targets viral NP for ubiquitination and protein degradation.
    Title: TRIM41-Mediated Ubiquitination of Nucleoprotein Limits Influenza A Virus Infection.
  7. Structure of importin-alpha bound to a non-classical nuclear localization signal of the influenza A virus nucleoprotein has been reported.
    Title: Structure of importin-α bound to a non-classical nuclear localization signal of the influenza A virus nucleoprotein.
  8. Immunoprecipitation studies revealed influenza A virus NS1 and NP as direct interaction partners of DDX3.
    Title: DDX3 Interacts with Influenza A Virus NS1 and NP Proteins and Exerts Antiviral Function through Regulation of Stress Granule Formation.
  9. Chimeric NP non coding regions between type A and C influenza viruses reveal their role in translation regulation.
    Title: Chimeric NP non coding regions between type A and C influenza viruses reveal their role in translation regulation.
  10. Residue 88 of NP interacts with polymerase PB2 and contributes to influenza A virus replication.
    Title: An important amino acid in nucleoprotein contributes to influenza A virus replication by interacting with polymerase PB2.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Pathways from PubChem

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General gene information

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Homology

unsure

  • Loc: 589

General protein information

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Preferred Names
nucleoprotein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002019.1 Reference assembly

    Range
    46..1542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_040982.1 nucleoprotein [Influenza A virus (A/Puerto Rico/8/1934(H1N1))]

    See identical proteins and their annotated locations for NP_040982.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2R4QPM3, F5CGM3, F5CGP5, M9V4N7, R9WJQ9, S5FZY4
    Conserved Domains (1) summary
    pfam00506
    Location:1 → 498
    Flu_NP; Influenza virus nucleoprotein
Nucleotide Protein
Heading Accession and Version

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