HA haemagglutinin [Influenza A virus (A/Puerto Rico/8/1934(H1N1))] - Gene

Summary

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Gene symbol: HA
Gene description: haemagglutinin
Locus tag: FLUAVs4gp1
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Influenza A virus (A/Puerto Rico/8/1934(H1N1)) (strain: A/Puerto Rico/8/1934, serotype: H1N1)
Lineage: Viruses; ssRNA viruses; ssRNA negative-strand viruses; Orthomyxoviridae; Influenzavirus A
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Genomic context

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Location:: segment: 4

Sequence:: NC_002017.1 (33..1733)

NC_002017.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_002017.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transmission of Human Influenza A Virus in Pigs Selects for Adaptive Mutations on the HA Gene.
Title: Transmission of Human Influenza A Virus in Pigs Selects for Adaptive Mutations on the HA Gene.
Monoclonal Antibody Targeting the HA191/199 Region of H1N1 Influenza Virus Mediates the Damage of Neural Cells.
Title: Monoclonal Antibody Targeting the HA191/199 Region of H1N1 Influenza Virus Mediates the Damage of Neural Cells.
Evaluation of HA-D222G/N polymorphism using targeted NGS analysis in A(H1N1)pdm09 influenza virus in Russia in 2018-2019.
Title: Evaluation of HA-D222G/N polymorphism using targeted NGS analysis in A(H1N1)pdm09 influenza virus in Russia in 2018-2019.
Cross protection by inactivated recombinant influenza viruses containing chimeric hemagglutinin conjugates with a conserved neuraminidase or M2 ectodomain epitope.
Title: Cross protection by inactivated recombinant influenza viruses containing chimeric hemagglutinin conjugates with a conserved neuraminidase or M2 ectodomain epitope.
Influenza Hemagglutinin Head Domain Mimicry by Rational Design.
Title: Influenza Hemagglutinin Head Domain Mimicry by Rational Design.
N-Linked Glycans and K147 Residue on Hemagglutinin Synergize To Elicit Broadly Reactive H1N1 Influenza Virus Antibodies.
Title: N-Linked Glycans and K147 Residue on Hemagglutinin Synergize To Elicit Broadly Reactive H1N1 Influenza Virus Antibodies.
Monoclonal antibody PR8-25 (MAb PR8-25) shown neutralizing activity both in vitro and in vivo. MAb PR8-25 shown reactivity with H1 subtype of influenza virus. The epitope of MAb PR8-25, 328-339aa, targeted in the stem region of hemagglutinin of H1N1 influenza A virus and located at the C-terminal of the HA1 fragment.
Title: An epitope on the stem region of hemagglutinin of H1N1 influenza A virus recognized by neutralizing monoclonal antibody.
Exploration of binding and inhibition mechanism of a small molecule inhibitor of influenza virus H1N1 hemagglutinin by molecular dynamics simulation.
Title: Exploration of binding and inhibition mechanism of a small molecule inhibitor of influenza virus H1N1 hemagglutinin by molecular dynamics simulation.
cellular kinase, casein kinase 1alpha (CK1alpha), is crucial for IAV HA-induced degradation of both IFNGR1 and IFNAR1.
Title: Casein Kinase 1α Mediates the Degradation of Receptors for Type I and Type II Interferons Caused by Hemagglutinin of Influenza A Virus.
MAb, MA-H generated against the seasonal A/Solomon Islands/03/2006 (H1N1) rHA binds within the head domain and bound the seasonal H1N1 (A/Solomon Islands/03/2006 and A/New Caledonia/20/1990) rHAs with high affinity (KD; 0.72-8.23 nM). MA-H showed high HI (2.50 mug/mL) and in vitro neutralization (IC50 = 2.61 mug/mL) activity against the A/Solomon Islands/03/2006 virus
Title: Neutralization and Binding Profile of Monoclonal Antibodies Generated Against Influenza A H1N1 Viruses.

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Pathways from PubChem

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General gene information

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Homology

Orthologs from OrthoDB

General protein information

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Preferred Names: haemagglutinin

Names: HA1; HA2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_002017.1 Reference assembly

Range

33..1733

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_040980.1 haemagglutinin [Influenza A virus (A/Puerto Rico/8/1934(H1N1))]

See identical proteins and their annotated locations for NP_040980.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A2R4QPL5, R9WNJ1, S5FR35

Conserved Domains (1) summary

pfam00509
Location:20 → 566

Hemagglutinin; Haemagglutinin
YP_163735.1 HA1

UniProtKB/TrEMBL

Q67131

Conserved Domains (1) summary

pfam00509
Location:3 → 327

Hemagglutinin; Haemagglutinin
YP_163736.1 HA2

Conserved Domains (1) summary

pfam00509
Location:1 → 222

Hemagglutinin; Haemagglutinin