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M2 matrix protein 2 [ Influenza A virus (A/Puerto Rico/8/1934(H1N1)) ]

Gene ID: 956528, updated on 18-Aug-2023

Summary

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Gene symbol
M2
Gene description
matrix protein 2
Locus tag
FLUAVs7gp2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Influenza A virus (A/Puerto Rico/8/1934(H1N1)) (strain: A/Puerto Rico/8/1934, serotype: H1N1)
Lineage
Viruses; ssRNA viruses; ssRNA negative-strand viruses; Orthomyxoviridae; Influenzavirus A
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Genomic context

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Location:
segment: 7
Sequence:
NC_002016.1 (26..1007)

NC_002016.1Genomic Context describing neighboring genes Neighboring gene matrix protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002016.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Glu-Glu-Tyr Sequence in the Cytoplasmic Tail of the M2 Protein Renders Influenza A Virus Susceptible to Restriction of the Hemagglutinin-M2 Association in Primary Human Macrophages. Bedi S, et al. J Virol, 2022 Sep 28. PMID 36098511, Free PMC Article
  2. Hydrophobic Residues at the Intracellular Domain of the M2 Protein Play an Important Role in Budding and Membrane Integrity of Influenza Virus. Bao D, et al. J Virol, 2022 May 11. PMID 35404081, Free PMC Article
  3. Influenza Antigens NP and M2 Confer Cross Protection to BALB/c Mice against Lethal Challenge with H1N1, Pandemic H1N1 or H5N1 Influenza A Viruses. Mytle N, et al. Viruses, 2021 Aug 27. PMID 34578289, Free PMC Article
  4. The L46P mutant confers a novel allosteric mechanism of resistance toward the influenza A virus M2 S31N proton channel blockers. Musharrafieh R, et al. Mol Pharmacol, 2019 Aug. PMID 31175183, Free PMC Article
  5. Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production. Wang R, et al. Autophagy, 2019 Jul. PMID 30741586, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Glu-Glu-Tyr Sequence in the Cytoplasmic Tail of the M2 Protein Renders Influenza A Virus Susceptible to Restriction of the Hemagglutinin-M2 Association in Primary Human Macrophages.
    Title: A Glu-Glu-Tyr Sequence in the Cytoplasmic Tail of the M2 Protein Renders Influenza A Virus Susceptible to Restriction of the Hemagglutinin-M2 Association in Primary Human Macrophages.
  2. Hydrophobic Residues at the Intracellular Domain of the M2 Protein Play an Important Role in Budding and Membrane Integrity of Influenza Virus.
    Title: Hydrophobic Residues at the Intracellular Domain of the M2 Protein Play an Important Role in Budding and Membrane Integrity of Influenza Virus.
  3. Influenza Antigens NP and M2 Confer Cross Protection to BALB/c Mice against Lethal Challenge with H1N1, Pandemic H1N1 or H5N1 Influenza A Viruses.
    Title: Influenza Antigens NP and M2 Confer Cross Protection to BALB/c Mice against Lethal Challenge with H1N1, Pandemic H1N1 or H5N1 Influenza A Viruses.
  4. MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes.
    Title: MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes.
  5. Cross protection by inactivated recombinant influenza viruses containing chimeric hemagglutinin conjugates with a conserved neuraminidase or M2 ectodomain epitope.
    Title: Cross protection by inactivated recombinant influenza viruses containing chimeric hemagglutinin conjugates with a conserved neuraminidase or M2 ectodomain epitope.
  6. M2 protein co-localizes and interacts with MAVS (mitochondrial antiviral signaling protein) on mitochondria, and positively regulates MAVS-mediated innate immunity.
    Title: Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production.
  7. Using the AM2 S31N channel blocker as a chemical probe, the study identifies a novel resistant mutant, L46P. The L46P mutant is located outside of the drug-binding site. Molecular dynamics simulations showed that L46P causes a dilation of drug-binding site between residues 22 and 31, which affects the binding of AM2 S31N channel blockers, but not the AM2 WT inhibitor amantadine.
    Title: The L46P mutant confers a novel allosteric mechanism of resistance toward the influenza A virus M2 S31N proton channel blockers.
  8. The data demonstrated that immunization with recombinant L. plantarum expressing 3M2e-Fc markedly reduced the viral load in the lung and protected against H1N1 influenza virus and mouse-adapted H9N2 avian influenza virus (AIV) challenge in BALB/c mice [M2e].
    Title: Protective efficacy of Fc targeting conserved influenza virus M2e antigen expressed by Lactobacillus plantarum.
  9. this work shows the production and isolation of a tetrameric and functional native M2 ion channel that will pave the way to structural and functional characterization of native M2, conformational antibody development, small molecules compounds screening towards vaccine treatment.
    Title: Expression and purification of native and functional influenza A virus matrix 2 proton selective ion channel.
  10. BST-2 restricts influenza A virus release and is countered by the viral M2 protein.
    Title: BST-2 restricts IAV release and is countered by the viral M2 protein.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
matrix protein 2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002016.1 Reference assembly

    Range
    26..1007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_040979.2 matrix protein 2 [Influenza A virus (A/Puerto Rico/8/1934(H1N1))]

    See identical proteins and their annotated locations for NP_040979.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A4GXH7, P06821, Q20N37, Q5UAV4, Q5UAV5, Q5UAV6, Q84105, Q8JUU3
    UniProtKB/TrEMBL
    A0A0E3H4Y8, A0A1D8EMN3, A0A1D8EMW5, A0A2R4QPL6, A0A3S5G6R9, A4ZNQ0, D3J179, F0TTA2, F0TTB3, F0TTC4, F0TTD5, F0TTE6, F0TTF7, F0TTG8, F5CGM5, F5CGN6, F5CGP7, M9V626, R9WKU2, R9WMI6, S5FTI3, T2ABK0
    Conserved Domains (1) summary
    pfam00599
    Location:1 → 97
    Flu_M2; Influenza Matrix protein (M2)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06821.1

Gene LinkOut

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