Kcnj13 potassium inwardly-rectifying channel, subfamily J, member 13 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnj13provided by RGD
Official Full Name: potassium inwardly-rectifying channel, subfamily J, member 13provided by RGD
Primary source: RGD:621661
See related: Ensembl:ENSRNOG00000016057 AllianceGenome:RGD:621661
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kir7.1
Summary: Predicted to enable inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of ion transmembrane transport. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 16 and snowflake vitreoretinal degeneration. Orthologous to human KCNJ13 (potassium inwardly rectifying channel subfamily J member 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 54.7), Thymus (RPKM 49.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q35

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (95509228..95528400, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (88063003..88071112, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (94486719..94495333, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kir7.1 knockdown and inhibition alter renal electrolyte handling but not the development of hypertension in Dahl salt-sensitive rats.
Title: K(ir)7.1 knockdown and inhibition alter renal electrolyte handling but not the development of hypertension in Dahl salt-sensitive rats.
Kir7.1 is expressed in epithelial cells all along the respiratory tree.
Title: Cleft Palate, Moderate Lung Developmental Retardation and Early Postnatal Lethality in Mice Deficient in the Kir7.1 Inwardly Rectifying K+ Channel.
Mutant subunits did not alter Kir7.1 channel selectivity.
Title: Characterization of the R162W Kir7.1 mutation associated with snowflake vitreoretinopathy.
Kir7.1 is involved in the development of renal K+ excretion between 14 and 21 days after birth under the condition of K+ overload.
Title: Expression of the K+ channel Kir7.1 in the developing rat kidney: role in K+ excretion.
results suggest that the C-terminal length plays an important role in the plasma-membrane localization of Kir7.1
Title: Role of C-terminus of Kir7.1 potassium channel in cell-surface expression.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables inward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inward rectifier potassium channel 13

Names: inward rectifier K(+) channel Kir7.1; potassium channel, inwardly rectifying subfamily J member 13; potassium voltage-gated channel subfamily J member 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053608.2 → NP_446060.1 inward rectifier potassium channel 13

See identical proteins and their annotated locations for NP_446060.1

Status: PROVISIONAL

Source sequence(s)

AB013890

UniProtKB/Swiss-Prot

O70617

UniProtKB/TrEMBL

A6JWM8

Related

ENSRNOP00000021507.2, ENSRNOT00000021507.4

Conserved Domains (1) summary

cl21560
Location:21 → 331

Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

95509228..95528400 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063267793.1 → XP_063123863.1 inward rectifier potassium channel 13 isoform X1

UniProtKB/Swiss-Prot

O70617

UniProtKB/TrEMBL

A6JWM8
XM_063267790.1 → XP_063123860.1 inward rectifier potassium channel 13 isoform X1

UniProtKB/Swiss-Prot

O70617

UniProtKB/TrEMBL

A6JWM8
XM_063267791.1 → XP_063123861.1 inward rectifier potassium channel 13 isoform X1

UniProtKB/Swiss-Prot

O70617

UniProtKB/TrEMBL

A6JWM8