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Acsl5 acyl-CoA synthetase long-chain family member 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 94340, updated on 11-Apr-2024

Summary

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Official Symbol
Acsl5provided by RGD
Official Full Name
acyl-CoA synthetase long-chain family member 5provided by RGD
Primary source
RGD:69402
See related
Ensembl:ENSRNOG00000016265 AllianceGenome:RGD:69402
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Acs5; Facl5
Summary
Enables arachidonate-CoA ligase activity. Involved in several processes, including organophosphate biosynthetic process; positive regulation of lipid metabolic process; and positive regulation of long-chain fatty acid import across plasma membrane. Located in mitochondrion. Colocalizes with endoplasmic reticulum. Orthologous to human ACSL5 (acyl-CoA synthetase long chain family member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 1524.8), Lung (RPKM 491.8) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q55
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (264294851..264341943)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (254289513..254336608)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (276240703..276290012)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene extensin-like Neighboring gene glycerol-3-phosphate acyltransferase, mitochondrial Neighboring gene tectorin beta Neighboring gene guanylate cyclase 2G Neighboring gene zinc finger DHHC-type palmitoyltransferase 6 Neighboring gene vesicle transport through interaction with t-SNAREs 1A Neighboring gene uncharacterized LOC134485256 Neighboring gene uncharacterized LOC134485255

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Hepatic long-chain acyl-CoA synthetase 5 mediates fatty acid channeling between anabolic and catabolic pathways. Bu SY, et al. J Lipid Res, 2010 Nov. PMID 20798351, Free PMC Article
  2. Rat long chain acyl-CoA synthetase 5 increases fatty acid uptake and partitioning to cellular triacylglycerol in McArdle-RH7777 cells. Mashek DG, et al. J Biol Chem, 2006 Jan 13. PMID 16263710
  3. Rat long chain acyl-CoA synthetase 5, but not 1, 2, 3, or 4, complements Escherichia coli fadD. Caviglia JM, et al. J Biol Chem, 2004 Mar 19. PMID 14711823
  4. A novel acyl-CoA synthetase, ACS5, expressed in intestinal epithelial cells and proliferating preadipocytes. Oikawa E, et al. J Biochem, 1998 Sep. PMID 9722683
  5. Human intestinal acyl-CoA synthetase 5 is sensitive to the inhibitor triacsin C. Kaemmerer E, et al. World J Gastroenterol, 2011 Nov 28. PMID 22171129, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The data strongly indicate that human but not rat acyl-CoA synthetase 5 is sensitive to triacsin C and does not compensate for other triacsin C-sensitive ACSL isoforms.
    Title: Human intestinal acyl-CoA synthetase 5 is sensitive to the inhibitor triacsin C.
  2. ACSL5 activates and channels fatty acids toward anabolic pathways
    Title: Hepatic long-chain acyl-CoA synthetase 5 mediates fatty acid channeling between anabolic and catabolic pathways.
  3. uptake of fatty acids into cells is regulated by metabolism and overexpressed ACSL5 partitions exogenously derived fatty acids toward TAG synthesis and storage
    Title: Rat long chain acyl-CoA synthetase 5 increases fatty acid uptake and partitioning to cellular triacylglycerol in McArdle-RH7777 cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables arachidonate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arachidonate-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables long-chain fatty acid-CoA ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables long-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables oleoyl-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables oleoyl-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables oleoyl-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in fatty acid metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in fatty acid transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in long-chain fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in long-chain fatty-acyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty-acyl-CoA biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phospholipid biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of fatty acid beta-oxidation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of long-chain fatty acid import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of long-chain fatty acid import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of triglyceride biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in response to cholesterol IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to glucose IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to sucrose IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
long-chain-fatty-acid--CoA ligase 5
Names
LACS 5
arachidonate--CoA ligase
fatty acid Coenzyme A ligase, long chain 5
long-chain acyl-CoA synthetase 5
long-chain fatty acid coenzyme A ligase 5
NP_446059.2
XP_038949085.1
XP_038949096.1
XP_038949101.1
XP_038949105.1
XP_063132073.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053607.2 → NP_446059.2  long-chain-fatty-acid--CoA ligase 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    O88813
    UniProtKB/TrEMBL
    A6JHY8, A6JHY9, Q6IN15
    Conserved Domains (1) summary
    cd05927
    Location:101 → 678
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    264294851..264341943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276003.1 → XP_063132073.1  long-chain-fatty-acid--CoA ligase 5 isoform X4

  2. XM_039093168.2 → XP_038949096.1  long-chain-fatty-acid--CoA ligase 5 isoform X1

    UniProtKB/Swiss-Prot
    O88813
    UniProtKB/TrEMBL
    A6JHY8, A6JHY9, Q6IN15
    Related
    ENSRNOP00000022126.7
    Conserved Domains (1) summary
    cd05927
    Location:101 → 678
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  3. XM_039093157.2 → XP_038949085.1  long-chain-fatty-acid--CoA ligase 5 isoform X1

    UniProtKB/Swiss-Prot
    O88813
    UniProtKB/TrEMBL
    A6JHY8, A6JHY9, Q6IN15
    Related
    ENSRNOP00000080415.1
    Conserved Domains (1) summary
    cd05927
    Location:101 → 678
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  4. XM_039093177.2 → XP_038949105.1  long-chain-fatty-acid--CoA ligase 5 isoform X3

    UniProtKB/Swiss-Prot
    O88813
    Conserved Domains (1) summary
    cd05927
    Location:78 → 655
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  5. XM_039093173.2 → XP_038949101.1  long-chain-fatty-acid--CoA ligase 5 isoform X2

    UniProtKB/Swiss-Prot
    O88813
    Conserved Domains (1) summary
    cd05927
    Location:96 → 673
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88813.1 GenPept UniProtKB/Swiss-Prot:O88813

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