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Mmp23 matrix metallopeptidase 23 [ Rattus norvegicus (Norway rat) ]

Gene ID: 94339, updated on 25-Apr-2024

Summary

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Official Symbol
Mmp23provided by RGD
Official Full Name
matrix metallopeptidase 23provided by RGD
Primary source
RGD:620201
See related
Ensembl:ENSRNOG00000017477 AllianceGenome:RGD:620201
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in several processes, including collagen catabolic process; extracellular matrix organization; and proteolysis. Predicted to be located in endoplasmic reticulum membrane and extracellular matrix. Predicted to be integral component of membrane. Predicted to be active in extracellular space. Orthologous to human MMP23B (matrix metallopeptidase 23B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Uterus (RPKM 90.0), Spleen (RPKM 53.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q36
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171521905..171525007, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166239643..166242734, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173078811..173082834, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 35, member E2B Neighboring gene cyclin-dependent kinase 11B Neighboring gene ribosomal protein L27A like 10 Neighboring gene MIB E3 ubiquitin protein ligase 2 Neighboring gene eukaryotic translation elongation factor 1 gamma, pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Intracellular trafficking of the KV1.3 potassium channel is regulated by the prodomain of a matrix metalloprotease. Nguyen HM, et al. J Biol Chem, 2013 Mar 1. PMID 23300077, Free PMC Article
  2. Cloning and characterization of a rat ortholog of MMP-23 (matrix metalloproteinase-23), a unique type of membrane-anchored matrix metalloproteinase and conditioned switching of its expression during the ovarian follicular development. Ohnishi J, et al. Mol Endocrinol, 2001 May. PMID 11328856
  3. Cloning and characterization of human MMP-23, a new matrix metalloproteinase predominantly expressed in reproductive tissues and lacking conserved domains in other family members. Velasco G, et al. J Biol Chem, 1999 Feb 19. PMID 9988691
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metalloendopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
matrix metalloproteinase-23
Names
MIFR
MMP-23
Matrix metalloproteinase 23
metalloprotease in the female reproductive tract
metaloprotease in the female reproductive tract

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053606.2 → NP_446058.1  matrix metalloproteinase-23

    See identical proteins and their annotated locations for NP_446058.1

    Status: PROVISIONAL

    Source sequence(s)
    BC086586
    UniProtKB/Swiss-Prot
    O88272
    UniProtKB/TrEMBL
    A6IUR3
    Related
    ENSRNOP00000061528.2, ENSRNOT00000066880.4
    Conserved Domains (4) summary
    smart00254
    Location:256 → 290
    ShKT; ShK toxin domain
    cd04278
    Location:88 → 255
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:88 → 255
    Peptidase_M10; Matrixin
    cl11960
    Location:314 → 376
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    171521905..171525007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110897.2 → XP_038966825.1  matrix metalloproteinase-23 isoform X3

    Conserved Domains (4) summary
    smart00254
    Location:218 → 252
    ShKT; ShK toxin domain
    cd04278
    Location:88 → 217
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    cd00096
    Location:294 → 298
    Ig; Ig strand C [structural motif]
    cl11960
    Location:276 → 338
    Ig; Immunoglobulin domain

  2. XM_039110895.2 → XP_038966823.1  matrix metalloproteinase-23 isoform X1

    Conserved Domains (4) summary
    smart00254
    Location:251 → 285
    ShKT; ShK toxin domain
    cd04278
    Location:88 → 250
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    cd00096
    Location:327 → 331
    Ig; Ig strand C [structural motif]
    cl11960
    Location:309 → 371
    Ig; Immunoglobulin domain

  3. XM_039110896.2 → XP_038966824.1  matrix metalloproteinase-23 isoform X2

    Conserved Domains (4) summary
    smart00254
    Location:245 → 279
    ShKT; ShK toxin domain
    cd04278
    Location:88 → 244
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    cd00096
    Location:321 → 325
    Ig; Ig strand C [structural motif]
    cl11960
    Location:303 → 365
    Ig; Immunoglobulin domain

  4. XM_017593671.3 → XP_017449160.1  matrix metalloproteinase-23 isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88272.1 GenPept UniProtKB/Swiss-Prot:O88272

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