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Atp5pf ATP synthase peripheral stalk subunit F6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 94271, updated on 5-Apr-2024

Summary

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Symbol
Atp5pfprovided by RGD
Full Name
ATP synthase peripheral stalk subunit F6provided by RGD
Primary source
RGD:621376
See related
AllianceGenome:RGD:621376
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Atp5j
Summary
Contributes to ATP hydrolysis activity. Involved in several processes, including negative regulation of icosanoid secretion; positive regulation of heart rate; and response to muscle activity. Located in cell surface; extracellular space; and mitochondrion. Part of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o). Used to study pulmonary hypertension. Biomarker of pulmonary hypertension. Orthologous to human ATP5PF (ATP synthase peripheral stalk subunit F6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 560.0), Muscle (RPKM 333.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
11q11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (37368045..37375721, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (23881594..23889581, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (24286806..24294419, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene junctional adhesion molecule 2 Neighboring gene GA binding protein transcription factor subunit alpha Neighboring gene uncharacterized LOC134480962 Neighboring gene amyloid beta precursor protein Neighboring gene cysteine and tyrosine rich 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Lung-specific RNA interference of coupling factor 6, a novel peptide, attenuates pulmonary arterial hypertension in rats. Yin J, et al. Respir Res, 2016 Aug 4. PMID 27491388, Free PMC Article
  2. Mitochondrial coupling factor 6 upregulation in hypertension-induced cardiac hypertrophy. He T, et al. Herz, 2015 Aug. PMID 25900768
  3. Comparison of gene and protein expressions in rats residing in standard cages with those having access to an exercise wheel. Alessio HM, et al. Biomed Res Int, 2014. PMID 24719897, Free PMC Article
  4. Coupling factor 6-induced prostacyclin inhibition is enhanced in vascular smooth muscle cells from spontaneously hypertensive rats. Osanai T, et al. J Hypertens, 2009 Sep. PMID 19474762
  5. Circulating coupling factor 6 in human hypertension: role of reactive oxygen species. Osanai T, et al. J Hypertens, 2003 Dec. PMID 14654753

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CF6 shRNA effectively inhibited CF6 expression, abolished lung macrophage infiltration, reversed endothelial dysfunction and vascular remodeling, and ameliorated the severity of pulmonary hypertension and right ventricular dysfunction at 4 weeks both as a pretreatment and rescue intervention
    Title: Lung-specific RNA interference of coupling factor 6, a novel peptide, attenuates pulmonary arterial hypertension in rats.
  2. plasma level increased markedly during pathogenesis of pulmonary arterial hypertension (PAH), indicating that CF6 may be involved in the development of PAH
    Title: Coupling Factor 6 Is Upregulated in Monocrotaline-induced Pulmonary Arterial Hypertension in Rats.
  3. CF6 protein was upregulated in cardiac hypertrophy induced by hypertension; further mechanisms involved in this process should be investigated.
    Title: Mitochondrial coupling factor 6 upregulation in hypertension-induced cardiac hypertrophy.
  4. suppresses prostacyclin generation in resistance arteriole vascular smooth muscle cells, which is enhanced in spontaneously hypertensive rats by the overproduction of CF6 and the hyperresponsiveness to CF6
    Title: Coupling factor 6-induced prostacyclin inhibition is enhanced in vascular smooth muscle cells from spontaneously hypertensive rats.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables proton transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to proton-transporting ATP synthase activity, rotational mechanism ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of arachidonic acid secretion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of prostaglandin secretion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of prostaglandin secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of blood pressure IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of heart rate IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proton motive force-driven ATP synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis ISO
Inferred from Sequence Orthology
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to muscle activity IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in substantia nigra development ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial proton-transporting ATP synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial proton-transporting ATP synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial proton-transporting ATP synthase complex ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATP synthase-coupling factor 6, mitochondrial
Names
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
ATPase subunit F6
coupling factor 6
NP_446054.1
XP_008766825.1
XP_017453574.1
XP_017453575.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001428996.1 → NP_001415925.1  ATP synthase-coupling factor 6, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011

  2. NM_001428997.1 → NP_001415926.1  ATP synthase-coupling factor 6, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011

  3. NM_053602.2 → NP_446054.1  ATP synthase-coupling factor 6, mitochondrial precursor

    See identical proteins and their annotated locations for NP_446054.1

    Status: PROVISIONAL

    Source sequence(s)
    X54510
    UniProtKB/Swiss-Prot
    P21571
    UniProtKB/TrEMBL
    A6JL59
    Conserved Domains (1) summary
    pfam05511
    Location:1 → 96
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    37368045..37375721 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017598085.3 → XP_017453574.1  ATP synthase-coupling factor 6, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    P21571
    UniProtKB/TrEMBL
    A6JL59
    Conserved Domains (1) summary
    pfam05511
    Location:1 → 96
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

  2. XM_017598086.3 → XP_017453575.2  ATP synthase-coupling factor 6, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8L2Q0A6

  3. XM_008768603.3 → XP_008766825.1  ATP synthase-coupling factor 6, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    P21571
    UniProtKB/TrEMBL
    A6JL59
    Conserved Domains (1) summary
    pfam05511
    Location:1 → 96
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21571.1 GenPept UniProtKB/Swiss-Prot:P21571

Gene LinkOut

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