Trim33 tripartite motif-containing 33 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trim33provided by MGI
Official Full Name: tripartite motif-containing 33provided by MGI
Primary source: MGI:MGI:2137357
See related: Ensembl:ENSMUSG00000033014 AllianceGenome:MGI:2137357
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ecto; Tif1g; 8030451N04Rik
Summary: Predicted to enable R-SMAD binding activity and co-SMAD binding activity. Predicted to be involved in negative regulation of BMP signaling pathway; protein ubiquitination; and regulation of transforming growth factor beta receptor signaling pathway. Located in nucleus. Is expressed in genitourinary system and submandibular gland primordium. Orthologous to human TRIM33 (tripartite motif containing 33). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E14 (RPKM 7.3), whole brain E14.5 (RPKM 7.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.2; 3 45.25 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (103186609..103266086)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (103279293..103358770)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tubular cell transcriptional intermediary factor 1gamma deficiency exacerbates kidney injury-induced tubular cell polyploidy and fibrosis.
Title: Tubular cell transcriptional intermediary factor 1γ deficiency exacerbates kidney injury-induced tubular cell polyploidy and fibrosis.
Downregulation of TRIM33 Promotes Survival and Epithelial-Mesenchymal Transition in Gastric Cancer.
Title: Downregulation of TRIM33 Promotes Survival and Epithelial-Mesenchymal Transition in Gastric Cancer.
The crystallin alpha B (HSPB5)-tripartite motif containing 33 (TRIM33) axis mediates myocardial fibrosis induced by angiotensinogen II through transforming growth factor-beta (TGF-beta1)-Smad3/4 signaling.
Title: The crystallin alpha B (HSPB5)-tripartite motif containing 33 (TRIM33) axis mediates myocardial fibrosis induced by angiotensinogen II through transforming growth factor-β (TGF-β1)-Smad3/4 signaling.
TRIM33 protects osteoblasts from oxidative stress-induced apoptosis in osteoporosis by inhibiting FOXO3a ubiquitylation and degradation.
Title: TRIM33 protects osteoblasts from oxidative stress-induced apoptosis in osteoporosis by inhibiting FOXO3a ubiquitylation and degradation.
TRIM33 prevents pulmonary fibrosis by impairing TGF-beta1 signalling.
Title: TRIM33 prevents pulmonary fibrosis by impairing TGF-β1 signalling.
Hepatic stellate cell-specific knockout of transcriptional intermediary factor 1gamma aggravates liver fibrosis.
Title: Hepatic stellate cell-specific knockout of transcriptional intermediary factor 1γ aggravates liver fibrosis.
Trim33 (Tif1gamma) is not required for skeletal muscle development or regeneration but suppresses cholecystokinin expression.
Title: Trim33 (Tif1γ) is not required for skeletal muscle development or regeneration but suppresses cholecystokinin expression.
results suggest that Trim33 is required for appropriate differentiation of precardiogenic mesoderm during late gastrulation and that it will likely mediate some of its functions via multi-protein complexes, many of which include the chromatin architectural and insulator protein Ctcf.
Title: Trim33 is required for appropriate development of pre-cardiogenic mesoderm.
we have shown that TRIM33 deficiency in myeloid cells during colitis is associated with increased production of blood monocytes, a defect in monocytes recruitment and differentiation into functional macrophages leading to failure to resolve intestinal inflammation.
Title: TRIM33 deficiency in monocytes and macrophages impairs resolution of colonic inflammation.
Trim33 promotes the proinflammatory function of Th17 cells by inducing IL-17 and suppressing IL-10 expression.
Title: Trim33 mediates the proinflammatory function of Th17 cells.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125699 (e-PCR)
- UniSTS:142435

RH124613 (e-PCR)
- UniSTS:161435

AI413936 (e-PCR)
- UniSTS:159168

Trim33 (e-PCR), detects polymorphism
- UniSTS:527587

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables R-SMAD binding	ISO Inferred from Sequence Orthology more info
enables co-SMAD binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRIM33

Names: RING-type E3 ubiquitin transferase TRIM33; TIF1-gamma; ectodermin homolog; transcription intermediary factor 1-gamma; tripartite motif-containing protein 33

NP_001073299.1

EC 2.3.2.27

NP_444400.2

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079830.2 → NP_001073299.1 E3 ubiquitin-protein ligase TRIM33 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.

Source sequence(s)

AC164089, AK129293

Consensus CDS

CCDS38574.1

UniProtKB/Swiss-Prot

Q6SI71, Q6ZPX5, Q99PP7

UniProtKB/TrEMBL

E9QME5

Related

ENSMUSP00000102473.2, ENSMUST00000106860.6

Conserved Domains (6) summary

cd05502
Location:971 → 1079

Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...

smart00502
Location:333 → 459

BBC; B-Box C-terminal domain

smart00336
Location:226 → 262

BBOX; B-Box-type zinc finger

cd00021
Location:288 → 326

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd00162
Location:138 → 202

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd15624
Location:902 → 947

PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)
NM_053170.3 → NP_444400.2 E3 ubiquitin-protein ligase TRIM33 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC164089, AY458590

Consensus CDS

CCDS38573.1

UniProtKB/Swiss-Prot

Q6SI71, Q6ZPX5, Q99PP7

UniProtKB/TrEMBL

E9QP19

Related

ENSMUSP00000029444.7, ENSMUST00000029444.13

Conserved Domains (6) summary

cd05502
Location:971 → 1096

Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...

smart00502
Location:333 → 459

BBC; B-Box C-terminal domain

smart00336
Location:226 → 262

BBOX; B-Box-type zinc finger

cd00021
Location:288 → 326

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd00162
Location:138 → 202

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd15624
Location:902 → 947

PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)