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Acox2 acyl-Coenzyme A oxidase 2, branched chain [ Mus musculus (house mouse) ]

Gene ID: 93732, updated on 5-Mar-2024

Summary

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Official Symbol
Acox2provided by MGI
Official Full Name
acyl-Coenzyme A oxidase 2, branched chainprovided by MGI
Primary source
MGI:MGI:1934852
See related
Ensembl:ENSMUSG00000021751 AllianceGenome:MGI:1934852
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
THCCox
Summary
Predicted to enable 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity; anion binding activity; and palmitoyl-CoA oxidase activity. Predicted to be involved in several processes, including fatty acid metabolic process; lipid homeostasis; and positive regulation of response to oxidative stress. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in peroxisome. Is expressed in several structures, including heart ventricle; liver; metanephros; and trunk. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 6. Orthologous to human ACOX2 (acyl-CoA oxidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 75.3), kidney adult (RPKM 54.4) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 A1; 14 4.77 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (14210406..14244262)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (8225511..8259019, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2610318M16 gene Neighboring gene FAM3 metabolism regulating signaling molecule D Neighboring gene family with sequence similarity 107, member A Neighboring gene STARR-seq mESC enhancer starr_35868 Neighboring gene STARR-seq mESC enhancer starr_35867 Neighboring gene potassium channel tetramerisation domain containing 6 Neighboring gene predicted gene, 53823

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Acox2 is a regulator of lysine crotonylation that mediates hepatic metabolic homeostasis in mice. Zhang Y, et al. Cell Death Dis, 2022 Mar 29. PMID 35351852, Free PMC Article
  2. The developmental regulation of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression in the liver is partially dissociated from the control of gluconeogenesis and lipid catabolism. Yubero P, et al. Endocrinology, 2004 Sep. PMID 15178647
  3. Prenatal and postnatal development of peroxisomal lipid-metabolizing pathways in the mouse. Huyghe S, et al. Biochem J, 2001 Feb 1. PMID 11171065, Free PMC Article
  4. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Kim SC, et al. Mol Cell, 2006 Aug. PMID 16916647
  5. The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease. Willnow T, et al. Organogenesis, 2005 Apr. PMID 19521566, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (4)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables acyl-CoA oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acid binding ISO
Inferred from Sequence Orthology
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyl-CoA oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in bile acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA oxidase IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA oxidase ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in very long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peroxisomal acyl-coenzyme A oxidase 2
Names
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase
THCA-CoA oxidase
branched chain acyl-CoA oxidase
trihydroxycoprostanoyl-CoA oxidase
NP_001155139.1
NP_444345.2
XP_006518171.1
XP_036014833.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161667.1 → NP_001155139.1  peroxisomal acyl-coenzyme A oxidase 2

    See identical proteins and their annotated locations for NP_001155139.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    CT025547
    Consensus CDS
    CCDS36801.1
    UniProtKB/Swiss-Prot
    Q8VCB0, Q9QXD1
    UniProtKB/TrEMBL
    Q3UNF3
    Related
    ENSMUSP00000022271.8, ENSMUST00000022271.14
    Conserved Domains (1) summary
    cd01150
    Location:20 → 655
    AXO; Peroxisomal acyl-CoA oxidase

  2. NM_053115.2 → NP_444345.2  peroxisomal acyl-coenzyme A oxidase 2

    See identical proteins and their annotated locations for NP_444345.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    CT025547
    Consensus CDS
    CCDS36801.1
    UniProtKB/Swiss-Prot
    Q8VCB0, Q9QXD1
    UniProtKB/TrEMBL
    Q3UNF3
    Related
    ENSMUSP00000126464.2, ENSMUST00000164598.8
    Conserved Domains (1) summary
    cd01150
    Location:20 → 655
    AXO; Peroxisomal acyl-CoA oxidase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    14210406..14244262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158940.1 → XP_036014833.1  peroxisomal acyl-coenzyme A oxidase 2 isoform X2

    UniProtKB/TrEMBL
    Q3UNF3
    Conserved Domains (1) summary
    cl09933
    Location:20 → 618
    ACAD; Acyl-CoA dehydrogenase

  2. XM_006518108.5 → XP_006518171.1  peroxisomal acyl-coenzyme A oxidase 2 isoform X1

    See identical proteins and their annotated locations for XP_006518171.1

    UniProtKB/Swiss-Prot
    Q8VCB0, Q9QXD1
    UniProtKB/TrEMBL
    Q3UNF3
    Conserved Domains (1) summary
    cd01150
    Location:20 → 655
    AXO; Peroxisomal acyl-CoA oxidase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QXD1.2 GenPept UniProtKB/Swiss-Prot:Q9QXD1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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