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CCNE2 cyclin E2 [ Homo sapiens (human) ]

Gene ID: 9134, updated on 3-Apr-2024

Summary

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Official Symbol
CCNE2provided by HGNC
Official Full Name
cyclin E2provided by HGNC
Primary source
HGNC:HGNC:1590
See related
Ensembl:ENSG00000175305 MIM:603775; AllianceGenome:HGNC:1590
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYCE2
Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 6.8), bone marrow (RPKM 6.2) and 20 other tissues See more
Orthologs
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Genomic context

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See CCNE2 in Genome Data Viewer
Location:
8q22.1
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (94880224..94896693, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (96005210..96021694, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (95892452..95907429, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene epithelial splicing regulatory protein 1 Neighboring gene ribosomal protein S15a pseudogene 26 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:95731221-95732175 Neighboring gene dpy-19 like 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19369 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27635 Neighboring gene integrator complex subunit 8 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:95906241-95906802 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19370 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19371 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19372 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19373 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19374 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27636 Neighboring gene small nucleolar RNA U13 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr8:95960947-95961575 and GRCh37_chr8:95961576-95962205 Neighboring gene tumor protein p53 inducible nuclear protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Clinical significance of CCNE2 protein and mRNA expression in thyroid cancer tissues. Liu CZ, et al. Adv Med Sci, 2020 Sep. PMID 33059229
  2. Antibiotic tigecycline inhibits cell proliferation, migration and invasion via down-regulating CCNE2 in pancreatic ductal adenocarcinoma. Yang J, et al. J Cell Mol Med, 2020 Apr. PMID 32141702, Free PMC Article
  3. Prognostic implication of morphology, cyclinE2 and proliferation in EBV-associated T/NK lymphoproliferative disease in non-immunocompromised hosts. Ng SB, et al. Orphanet J Rare Dis, 2014 Dec 5. PMID 25475054, Free PMC Article
  4. [Expression and clinical significance of cyclin E2 in nasopharyngeal carcinoma]. Zhao GH, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2012 Mar. PMID 22394640
  5. Deregulation of cyclin E2 expression and associated kinase activity in primary breast tumors. Payton M, et al. Oncogene, 2002 Dec 5. PMID 12466974

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of miR-503-5p Promotes the Development of Pancreatic Cancer by Targeting Cyclin E2.
    Title: Downregulation of miR-503-5p Promotes the Development of Pancreatic Cancer by Targeting Cyclin E2.
  2. Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve.
    Title: Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve.
  3. E2F transcription factor 1 (E2F1) promotes the transforming growth factor TGF-beta1 induced human cardiac fibroblasts differentiation through promoting the transcription of CCNE2 gene.
    Title: E2F transcription factor 1 (E2F1) promotes the transforming growth factor TGF-β1 induced human cardiac fibroblasts differentiation through promoting the transcription of CCNE2 gene.
  4. Vascular endothelial cell-derived exosomal miR-30a-5p inhibits lung adenocarcinoma malignant progression by targeting CCNE2.
    Title: Vascular endothelial cell-derived exosomal miR-30a-5p inhibits lung adenocarcinoma malignant progression by targeting CCNE2.
  5. SP1-induced overexpression of LINC00520 facilitates non-small cell lung cancer progression through miR-577/CCNE2 pathway and predicts poor prognosis.
    Title: SP1-induced overexpression of LINC00520 facilitates non-small cell lung cancer progression through miR-577/CCNE2 pathway and predicts poor prognosis.
  6. Clinical significance of CCNE2 protein and mRNA expression in thyroid cancer tissues.
    Title: Clinical significance of CCNE2 protein and mRNA expression in thyroid cancer tissues.
  7. Antibiotic tigecycline inhibits cell proliferation, migration and invasion via down-regulating CCNE2 in pancreatic ductal adenocarcinoma.
    Title: Antibiotic tigecycline inhibits cell proliferation, migration and invasion via down-regulating CCNE2 in pancreatic ductal adenocarcinoma.
  8. RFC2, a direct target of miR-744, modulates the cell cycle and promotes the proliferation of CRC cells.
    Title: RFC2, a direct target of miR-744, modulates the cell cycle and promotes the proliferation of CRC cells.
  9. CARM1 promotes non-small cell lung cancer progression through upregulating CCNE2 expression.
    Title: CARM1 promotes non-small cell lung cancer progression through upregulating CCNE2 expression.
  10. Nicotine-upregulated miR-30a arrests cell cycle in G1 phase by directly targeting CCNE2 in human periodontal ligament cells.
    Title: Nicotine-upregulated miR-30a arrests cell cycle in G1 phase by directly targeting CCNE2 in human periodontal ligament cells.
Submit: New GeneRIF Correction See all GeneRIFs (40)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in homologous chromosome pairing at meiosis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of protein localization IEA
Inferred from Electronic Annotation
more info
  
involved_in telomere maintenance IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin E1-CDK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin E2-CDK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
G1/S-specific cyclin-E2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029611.1 RefSeqGene

    Range
    5054..20031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057749.3 → NP_477097.1  G1/S-specific cyclin-E2

    See identical proteins and their annotated locations for NP_477097.1

    Status: REVIEWED

    Source sequence(s)
    AF091433, BJ990268, DB547256
    Consensus CDS
    CCDS6264.1
    UniProtKB/Swiss-Prot
    O95439, O96020
    UniProtKB/TrEMBL
    Q8WUE3
    Related
    ENSP00000309181.4, ENST00000308108.9
    Conserved Domains (2) summary
    pfam00134
    Location:112 → 239
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:241 → 361
    Cyclin_C; Cyclin, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    94880224..94896693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013958.2 → XP_016869447.1  G1/S-specific cyclin-E2 isoform X1

    UniProtKB/Swiss-Prot
    O95439, O96020
    UniProtKB/TrEMBL
    Q8WUE3
    Related
    ENSP00000429089.1, ENST00000520509.5
    Conserved Domains (2) summary
    pfam00134
    Location:112 → 239
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:241 → 361
    Cyclin_C; Cyclin, C-terminal domain

  2. XM_047422411.1 → XP_047278367.1  G1/S-specific cyclin-E2 isoform X1

    UniProtKB/Swiss-Prot
    O95439, O96020

  3. XM_017013959.2 → XP_016869448.1  G1/S-specific cyclin-E2 isoform X1

    UniProtKB/Swiss-Prot
    O95439, O96020
    UniProtKB/TrEMBL
    Q8WUE3
    Conserved Domains (2) summary
    pfam00134
    Location:112 → 239
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:241 → 361
    Cyclin_C; Cyclin, C-terminal domain

  4. XM_011517366.3 → XP_011515668.1  G1/S-specific cyclin-E2 isoform X2

    Conserved Domains (1) summary
    pfam00134
    Location:112 → 239
    Cyclin_N; Cyclin, N-terminal domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    96005210..96021694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361489.1 → XP_054217464.1  G1/S-specific cyclin-E2 isoform X1

    UniProtKB/Swiss-Prot
    O95439, O96020

  2. XM_054361491.1 → XP_054217466.1  G1/S-specific cyclin-E2 isoform X1

    UniProtKB/Swiss-Prot
    O95439, O96020

  3. XM_054361490.1 → XP_054217465.1  G1/S-specific cyclin-E2 isoform X1

    UniProtKB/Swiss-Prot
    O95439, O96020

  4. XM_054361492.1 → XP_054217467.1  G1/S-specific cyclin-E2 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_004702.2: Suppressed sequence

    Description
    NM_004702.2: This RefSeq was permanently suppressed because the transcript has insufficient support and is a nonsense-mediated mRNA decay (NMD) candidate.

  2. NM_057735.1: Suppressed sequence

    Description
    NM_057735.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O96020.1 GenPept UniProtKB/Swiss-Prot:O96020

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