Vegfb vascular endothelial growth factor B [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Vegfbprovided by RGD
Full Name: vascular endothelial growth factor Bprovided by RGD
Primary source: RGD:619799
See related: Ensembl:ENSRNOG00000021156 AllianceGenome:RGD:619799
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity; receptor ligand activity; and vascular endothelial growth factor receptor 1 binding activity. Involved in angiogenesis and response to xenobiotic stimulus. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Biomarker of retinal vein occlusion. Human ortholog(s) of this gene implicated in myocardial infarction and pulmonary hypertension. Orthologous to human VEGFB (vascular endothelial growth factor B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 139.2), Muscle (RPKM 48.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (213601570..213607254, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (204172297..204178046, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (222237000..222242786, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA TINCR improves cardiac hypertrophy by regulating the miR-211-3p-VEGFB-SDF-1alpha-CXCR4 pathway.
Title: LncRNA TINCR improves cardiac hypertrophy by regulating the miR-211-3p-VEGFB-SDF-1α-CXCR4 pathway.
Cardiac-specific VEGFB overexpression reduces lipoprotein lipase activity and improves insulin action in rat heart.
Title: Cardiac-specific VEGFB overexpression reduces lipoprotein lipase activity and improves insulin action in rat heart.
Loss of VEGFB and its downstream signaling is an early event following hyperglycemia, is sustained with disease progression, and could explain diabetic cardiomyopathy.
Title: Loss of VEGFB and its signaling in the diabetic heart is associated with increased cell death signaling.
Data suggest that dietary fatty acids create epigenetic/nutrigenomic changes in methylation levels of CpG island at Vegfb promoter and changes in Vegfb expression in white adipocytes in vivo and in vitro, with particular up-regulation of DNA methylation by linoleic acid; Vegfb promoter methylation levels are closely related to Vegfb gene expression in visceral and subcutaneous adipose tissue.
Title: Methylation patterns of Vegfb promoter are associated with gene and protein expression levels: the effects of dietary fatty acids.
Combined inhibition of PGDF and VEGF with sunitinib prevents chronic rejection changes in experimental kidney transplantation.
Title: Oral Platelet-Derived Growth Factor and Vascular Endothelial Growth Factor Inhibitor Sunitinib Prevents Chronic Allograft Injury in Experimental Kidney Transplantation Model.
Cardiac VEGF-B mRNA expression decreases following heart transplantation.
Title: Cardiac VEGF-B expression decreases along with cardiac allograft unload.
VEGF-B has important effects on the functional architecture of the visual cortex.
Title: Vascular endothelial growth factor B prevents the shift in the ocular dominance distribution of visual cortical neurons in monocularly deprived rats.
results demonstrate that the vascular endothelium can function as an efficient barrier to excess muscle lipid uptake even under conditions of severe obesity and type 2 diabetes, and that this barrier can be maintained by inhibition of VEGF-B signalling
Title: Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes.
Transcript level of angiogenesis-related genes, Vegfb and its transcription factor gene, Hif1a, those being downstream of phosphatase and tensin homolog (PTEN)/Akt signaling, were up-regulated in the thyroid tissue with Cochineal extracts administration.
Title: Promoting effects of carminic acid-enriched cochineal extracts on capsular invasive thyroid carcinomas through targeting activation of angiogenesis in rats.
VEGFB and PlGF can either inhibit or potentiate the actions of VEGFA, depending on their relative concentrations, which change in the hypoxic lung.
Title: Placenta growth factor and vascular endothelial growth factor B expression in the hypoxic lung.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chemoattractant activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemoattractant activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables vascular endothelial growth factor receptor 1 binding	ISO Inferred from Sequence Orthology more info
enables vascular endothelial growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within coronary vasculature development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in induction of positive chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in induction of positive chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mast cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mast cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
NOT involved_in positive regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular wound healing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein O-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in vascular endothelial growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in vascular endothelial growth factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: vascular endothelial growth factor B

Names: VEGF-B; VEGF-related factor; VRF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053549.1 → NP_446001.1 vascular endothelial growth factor B precursor

See identical proteins and their annotated locations for NP_446001.1

Status: PROVISIONAL

Source sequence(s)

BC076395

UniProtKB/TrEMBL

A0A8I6ADH5, A6HZM0

Related

ENSRNOP00000049757.3, ENSRNOT00000050891.4

Conserved Domains (1) summary

smart00141
Location:45 → 126

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

213601570..213607254 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006230912.5 → XP_006230974.1 vascular endothelial growth factor B isoform X2

UniProtKB/TrEMBL

A0A8I5YBQ7, A0A8I6ADH5, A6HZM0

Related

ENSRNOP00000076555.1

Conserved Domains (1) summary

smart00141
Location:45 → 126

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
XM_006230910.5 → XP_006230972.1 vascular endothelial growth factor B isoform X1

See identical proteins and their annotated locations for XP_006230972.1

UniProtKB/Swiss-Prot

O35485, O54881, Q6DGF3

UniProtKB/TrEMBL

A6HZM1

Conserved Domains (1) summary

smart00141
Location:45 → 126

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
XM_039092980.2 → XP_038948908.1 vascular endothelial growth factor B isoform X1

UniProtKB/Swiss-Prot

O35485, O54881, Q6DGF3

UniProtKB/TrEMBL

A6HZM1

Conserved Domains (1) summary

smart00141
Location:45 → 126

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
XM_006230911.5 → XP_006230973.1 vascular endothelial growth factor B isoform X1

See identical proteins and their annotated locations for XP_006230973.1

UniProtKB/Swiss-Prot

O35485, O54881, Q6DGF3

UniProtKB/TrEMBL

A6HZM1

Conserved Domains (1) summary

smart00141
Location:45 → 126

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
XM_039092992.2 → XP_038948920.1 vascular endothelial growth factor B isoform X3

UniProtKB/TrEMBL

A0A8I6ADH5, A6HZM0

Conserved Domains (1) summary

smart00141
Location:45 → 126

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
XM_039092996.2 → XP_038948924.1 vascular endothelial growth factor B isoform X4

Conserved Domains (1) summary

cl00116
Location:45 → 100

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
XM_039093000.2 → XP_038948928.1 vascular endothelial growth factor B isoform X5

Conserved Domains (1) summary

cl00116
Location:45 → 100

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...