U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gna15 G protein subunit alpha 15 [ Rattus norvegicus (Norway rat) ]

Gene ID: 89788, updated on 13-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Gna15provided by RGD
Official Full Name
G protein subunit alpha 15provided by RGD
Primary source
RGD:619751
See related
Ensembl:ENSRNOG00000005378 AllianceGenome:RGD:619751
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hg1l
Summary
Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in phospholipase C-activating G protein-coupled receptor signaling pathway. Located in membrane. Orthologous to human GNA15 (G protein subunit alpha 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 56.8), Thymus (RPKM 32.3) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
7q11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (8835396..8856269)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8184632..8205508)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11054249..11075152)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene TLE family member 5, transcriptional modulator Neighboring gene G protein subunit alpha 11 Neighboring gene sphingosine-1-phosphate receptor 4 Neighboring gene nicalin

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of two alpha-subunit species of GTP-binding proteins, Galpha15 and Galphaq, expressed in rat taste buds. Kusakabe Y, et al. Biochim Biophys Acta, 1998 Jul 24. PMID 9685675
  2. Normal hematopoiesis and inflammatory responses despite discrete signaling defects in Galpha15 knockout mice. Davignon I, et al. Mol Cell Biol, 2000 Feb. PMID 10629036, Free PMC Article
  3. Regulation of phosphoinositide-specific phospholipase C. Rhee SG. Annu Rev Biochem, 2001. PMID 11395409, Free PMC Article
  4. Cloning and characterization of a rabbit ortholog of human Galpha16 and mouse G(alpha)15. Feild JA, et al. FEBS Lett, 1999 Oct 22. PMID 10571060
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables G-protein beta/gamma-subunit complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G-protein beta/gamma-subunit complex binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within_positive_effect calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipase C-activating dopamine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
guanine nucleotide-binding protein subunit alpha-15
Names
g alpha-15
guanine nucleotide binding protein, alpha 15
heterotrimeric guanine nucleotide-binding protein 1l

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053542.2 → NP_445994.2  guanine nucleotide-binding protein subunit alpha-15

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    O88302
    UniProtKB/TrEMBL
    A6K873, G3V6N8
    Related
    ENSRNOP00000007202.2, ENSRNOT00000007202.5
    Conserved Domains (1) summary
    cd00066
    Location:43 → 368
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    8835396..8856269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264349.1 → XP_063120419.1  guanine nucleotide-binding protein subunit alpha-15 isoform X2

  2. XM_063264350.1 → XP_063120420.1  guanine nucleotide-binding protein subunit alpha-15 isoform X3

  3. XM_006241021.5 → XP_006241083.1  guanine nucleotide-binding protein subunit alpha-15 isoform X1

    UniProtKB/Swiss-Prot
    O88302
    Conserved Domains (2) summary
    cd00066
    Location:43 → 367
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    smart00275
    Location:22 → 371
    G_alpha; G protein alpha subunit
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88302.1 GenPept UniProtKB/Swiss-Prot:O88302

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous