inhA NADH-dependent enoyl-[ACP] reductase [Mycobacterium tuberculosis H37Rv] - Gene

Summary

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Gene symbol: inhA
Gene description: NADH-dependent enoyl-[ACP] reductase
Locus tag: Rv1484
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage: Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:: NC_000962.3 (1674202..1675011)

NC_000962.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000962.3

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pattern of InhA and KatG mutations in isoniazid mono resistant Mycobacterium tuberculosis isolates from Odisha.
Title: Pattern of InhA and KatG mutations in isoniazid mono resistant Mycobacterium tuberculosis isolates from Odisha.
In Vitro Antimycobacterial Activity and Physicochemical Characterization of Diaryl Ether Triclosan Analogues as Potential InhA Reductase Inhibitors.
Title: In Vitro Antimycobacterial Activity and Physicochemical Characterization of Diaryl Ether Triclosan Analogues as Potential InhA Reductase Inhibitors.
Identification of Novel Cytotoxic T Lymphocyte Epitopes of Drug- Resistance Related Protein InhA from Mycobacterium tuberculosis.
Title: Identification of Novel Cytotoxic T Lymphocyte Epitopes of Drug- Resistance Related Protein InhA from Mycobacterium tuberculosis.
This study provides valuable information on the diversity of polymorphisms in genes related to multidrug-resistant tuberculosis (including inhA), as well as the presence of new mutations not previously described; this information should be considered in the implementation of molecular diagnostic tests
Title: rpoB, katG and inhA mutations in multi-drug resistant strains of Mycobacterium tuberculosis clinical isolates from southeast Mexico.
Among the inhibin alpha promoter region mutations, 2(6.6%) of the thirty isoniazid resistant isolates had the most common C15T mutation in the promoter region.
Title: Molecular characterisation of isoniazid resistant clinical isolates of Mycobacterium tuberculosis from Khyber Pakhtunkhwa, Pakistan.
The formation of a covalent adduct during the InhA catalytic cycle and identified critical residues required for catalysis.
Title: InhA, the enoyl-thioester reductase from Mycobacterium tuberculosis forms a covalent adduct during catalysis.
It showed two molecules with comparatively higher affinity toward InhA as compared to potent molecule. It indicated the candidature of identified molecules to be further considered in anti-TB drug development pipeline.
Title: Cell wall permeability assisted virtual screening to identify potential direct InhA inhibitors of Mycobacterium tuberculosis and their biological evaluation.
Studied DNA-directed RNA polymerase subunit beta (rpoB), catalase-peroxidase (katG) and NADH-dependent enoyl-[ACP] reductase (inhA) mutations in clinical drug resistant Mycobacterium tuberculosis isolates.
Title: Differences in rpoB, katG and inhA mutations between new and previously treated tuberculosis cases using the GenoType MTBDRplus assay.
Study examine previously unstudied catalytic pocket residues through mutations in terms of their kinetics relating to NADH and DD-CoA substrate binding and turnover. The results demonstrate that mutation of NADH-binding pocket residues can have profound effects on DD-CoA binding and suggest that there are long range molecular interactions in the InhA protein.
Title: Disruption of key NADH-binding pocket residues of the Mycobacterium tuberculosis InhA affects DD-CoA binding ability.
Out of the 141 isolates studied, 3 (2.1%) were found carrying mutations in the katG gene that confer resistance to Isoniazid (INH). No mutations were detected in the inhA promoter region gene that confer weak INH resistance or in the rpoB gene that confer Rifampicin resistance.
Title: The occurrence and frequency of genomic mutations that mediate Isoniazid and Rifampicin resistance in Mycobacterium tuberculosis isolates from untreated pulmonary Tuberculosis cases in urban Blantyre, Malawi.

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Pathways from PubChem

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General gene information

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Homology

Orthologs from OrthoDB

General protein information

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Preferred Names: NADH-dependent enoyl-[ACP] reductase

NP_216000.1

NADH-dependent enoyl-ACP reductase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000962.3 Reference assembly

Range

1674202..1675011

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_216000.1 NADH-dependent enoyl-[ACP] reductase [Mycobacterium tuberculosis H37Rv]

See identical proteins and their annotated locations for NP_216000.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A4Y5N117, Q4TUY1

Conserved Domains (1) summary

PRK07889
Location:1 → 269

PRK07889; enoyl-[acyl-carrier-protein] reductase FabI

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
2NSD_A.1
2NSD_B.1
2PR2_A.1
2X22_A.1
2X22_B.1
2X23_A.1
2X23_B.1
2X23_E.1
2X23_G.1
3OEW_A.1
4BII_A.1
4BII_B.1
4BII_C.1
4BII_D.1
4BQP_A.1
4BQP_B.1
4BQP_C.1
4BQP_D.1
4BQP_E.1
4BQP_F.1
4BQR_A.1
4BQR_B.1
4BQR_C.1
4BQR_D.1
4D0S_A.1
4D0S_B.1
4D0S_C.1
4D0S_D.1
4QXM_A.1
4QXM_C.1
4QXM_E.1
4QXM_G.1
4TZK_A.1
4TZT_A.1
4U0J_A.1
4U0K_A.1
4UVD_A.1
4UVE_A.1
4UVG_A.1
4UVH_A.1
4UVH_B.1
4UVH_C.1
4UVH_D.1
4UVI_A.1
4UVI_B.1
4UVI_C.1
4UVI_D.1
5G0S_A.1
5G0S_B.1
5G0S_C.1
5G0S_D.1
5G0T_A.1
5G0T_B.1
5G0T_C.1
5G0T_D.1
5G0U_A.1
5G0U_B.1
5G0U_C.1
5G0U_D.1
5G0V_A.1
5G0V_B.1
5G0V_C.1
5G0V_D.1
5G0W_A.1
5G0W_B.1
5G0W_C.1
5G0W_D.1
5JFO_A.1
5JFO_B.1
5JFO_C.1
5JFO_D.1
P9WGR1.1