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SUCLG2 succinate-CoA ligase GDP-forming subunit beta [ Homo sapiens (human) ]

Gene ID: 8801, updated on 7-Apr-2024

Summary

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Official Symbol
SUCLG2provided by HGNC
Official Full Name
succinate-CoA ligase GDP-forming subunit betaprovided by HGNC
Primary source
HGNC:HGNC:11450
See related
Ensembl:ENSG00000172340 MIM:603922; AllianceGenome:HGNC:11450
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G-SCS; GBETA; GTPSCS
Summary
This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. [provided by RefSeq, Apr 2010]
Expression
Ubiquitous expression in colon (RPKM 21.2), kidney (RPKM 16.3) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
3p14.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (67360460..67654612, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (67405452..67699926, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (67410884..67705036, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112267879 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:67346086-67347285 Neighboring gene microRNA 4272 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:67494181-67494886 Neighboring gene MPRA-validated peak4691 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr3:67603587-67603736 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20048 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 7041 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20049 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:67704843-67705342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14513 Neighboring gene SUCLG2 divergent transcript Neighboring gene FAM19A1 intron homotypic cluster of transcription factor binding sites enhancer Neighboring gene TAFA chemokine like family member 1 Neighboring gene COP9 signalosome subunit 8 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells. Wu B, et al. Cell Metab, 2020 Dec 1. PMID 33264602, Free PMC Article
  2. Identification of novel biomarker and therapeutic target candidates for diagnosis and treatment of follicular carcinoma. Lai X, et al. J Proteomics, 2017 Aug 23. PMID 28709933
  3. The interplay between SUCLA2, SUCLG2, and mitochondrial DNA depletion. Miller C, et al. Biochim Biophys Acta, 2011 May. PMID 21295139
  4. A Fast Implementation of a Scan Statistic for Identifying Chromosomal Patterns of Genome Wide Association Studies. Sun YV, et al. Comput Stat Data Anal, 2009 Mar 15. PMID 20161066, Free PMC Article
  5. EGFR-upregulated LIFR promotes SUCLG2-dependent castration resistance and neuroendocrine differentiation of prostate cancer. Lin SR, et al. Oncogene, 2020 Oct. PMID 32963351

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells.
    Title: Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells.
  2. EGFR-upregulated LIFR promotes SUCLG2-dependent castration resistance and neuroendocrine differentiation of prostate cancer.
    Title: EGFR-upregulated LIFR promotes SUCLG2-dependent castration resistance and neuroendocrine differentiation of prostate cancer.
  3. SUCLG2 has a sensitivity of 75% and a specificity of 80% to distinguish follicular carcinoma from follicular adenoma
    Title: Identification of novel biomarker and therapeutic target candidates for diagnosis and treatment of follicular carcinoma.
  4. The absence of SUCLA2 and SUCLG2 in human glia is in compliance with the presence of alternative pathways occurring in these cells, namely the GABA shunt and ketone body metabolism
    Title: Localization of SUCLA2 and SUCLG2 subunits of succinyl CoA ligase within the cerebral cortex suggests the absence of matrix substrate-level phosphorylation in glial cells of the human brain.
  5. SUCLG2 has been identified as both a determinator of CSF amyloid beta-protein (1-42) levels and as attenuator of cognitive decline in Alzheimer's disease.
    Title: SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease.
  6. Loss of SUCLG2 is associated with mitochondrial DNA depletion and results in mitochondrial depletion syndrome.
    Title: The interplay between SUCLA2, SUCLG2, and mitochondrial DNA depletion.
  7. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
  8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  9. Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: A Fast Implementation of a Scan Statistic for Identifying Chromosomal Patterns of Genome Wide Association Studies.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.
EBI GWAS Catalog
An atlas of genetic influences on human blood metabolites.
EBI GWAS Catalog
Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism.
EBI GWAS Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog
SUCLG2 identified as both a determinator of CSF Aß1-42-levels and an attenuator of cognitive decline in Alzheimer's disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of succinate-CoA ligase, GDP-forming, beta subunit (SUCLG2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with succinate-CoA ligase, GDP-forming, beta subunit (SUCLG2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
integrase gag-pol HIV-1 IN is identified to have a physical interaction with succinate-CoA ligase, GDP-forming, beta subunit (SUCLG2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables succinate-CoA ligase (ADP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables succinate-CoA ligase (GDP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables succinate-CoA ligase (GDP-forming) activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in succinate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in succinyl-CoA catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in succinyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in succinyl-CoA metabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  
located_in mitochondrion NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
part_of succinate-CoA ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of succinate-CoA ligase complex (GDP-forming) IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
Names
GTP-specific succinyl-CoA synthetase beta subunit
GTP-specific succinyl-CoA synthetase subunit beta
SCS-betaG
succinate-CoA ligase GDP-forming beta subunit
succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
succinyl-CoA ligase, GDP-forming, beta chain, mitochondrial
succinyl-CoA synthetase, beta-G chain
NP_001171070.1
NP_003839.2
XP_016862909.1
XP_047305096.1
XP_054204242.1
XP_054204243.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052945.1 RefSeqGene

    Range
    5003..284896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001177599.2 → NP_001171070.1  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC112213, AK310527, BC068602
    Consensus CDS
    CCDS54605.1
    UniProtKB/TrEMBL
    E9PDQ8
    Related
    ENSP00000419325.1, ENST00000493112.5
    Conserved Domains (3) summary
    PRK00696
    Location:39 → 396
    sucC; succinyl-CoA synthetase subunit beta; Provisional
    pfam00549
    Location:306 → 396
    Ligase_CoA; CoA-ligase
    pfam08442
    Location:39 → 247
    ATP-grasp_2; ATP-grasp domain

  2. NM_003848.4 → NP_003839.2  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_003839.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR, and 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF131748, BC007716, BC068602
    Consensus CDS
    CCDS43104.1
    UniProtKB/Swiss-Prot
    C9JVT2, O95195, Q6NUH7, Q86VX8, Q8WUQ1, Q96I99
    UniProtKB/TrEMBL
    Q3ZCW5
    Related
    ENSP00000307432.5, ENST00000307227.10
    Conserved Domains (3) summary
    PRK00696
    Location:39 → 420
    sucC; succinyl-CoA synthetase subunit beta; Provisional
    pfam00549
    Location:306 → 420
    Ligase_CoA; CoA-ligase
    pfam08442
    Location:39 → 247
    ATP-grasp_2; ATP-grasp domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    67360460..67654612 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007420.3 → XP_016862909.1  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform X1

    UniProtKB/TrEMBL
    E9PDQ8
    Related
    ENSP00000417589.1, ENST00000492795.1

  2. XM_047449140.1 → XP_047305096.1  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform X2

RNA

  1. XR_007095763.1 RNA Sequence

  2. XR_001740350.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    67405452..67699926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348267.1 → XP_054204242.1  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform X1

  2. XM_054348268.1 → XP_054204243.1  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform X2

RNA

  1. XR_008486847.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96I99.2 GenPept UniProtKB/Swiss-Prot:Q96I99

Gene LinkOut

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