RGS11 regulator of G protein signaling 11 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RGS11provided by HGNC
Official Full Name: regulator of G protein signaling 11provided by HGNC
Primary source: HGNC:HGNC:9993
See related: Ensembl:ENSG00000076344 MIM:603895; AllianceGenome:HGNC:9993
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RS11
Summary: The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2013]
Expression: Broad expression in brain (RPKM 9.1), fat (RPKM 7.5) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16p13.3

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (268307..275944, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (263137..270775, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (318306..325944, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of RGS11 promotes cell migration, participates in tumor metastasis, and correlates the clinicopathological conditions of patients with lung adenocarcinoma.
Title: Overexpression of regulator of G protein signaling 11 promotes cell migration and associates with advanced stages and aggressiveness of lung adenocarcinoma.
In granulosa cells, there are significant changes in expression during follicular maturation.
Title: Differential expression of poliovirus receptor, regulator of G-protein signaling 11 and erythrocyte protein band 4.1-like 3 in human granulosa cells during follicular growth and maturation.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.
the successful purification of functionally intact Gbeta5-free recombinant RGS11 was reported that differentially interact with R7BP and Galpha(oa).
Title: RGS11 interacts preferentially with R7BP over Galpha(oa)--characterization of Gbeta5-free RGS11.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of hematological and biochemical traits in a Japanese population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of regulator of G-protein signaling 11 (RGS11) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ECD00760 (e-PCR)
- UniSTS:281869

REN95322 (e-PCR)
- UniSTS:420120

REN95323 (e-PCR)
- UniSTS:420121

REN95324 (e-PCR)
- UniSTS:420122

REN95325 (e-PCR)
- UniSTS:420123

REN95326 (e-PCR)
- UniSTS:420124

REN95327 (e-PCR)
- UniSTS:420125

ECD10574 (e-PCR)
- UniSTS:291613

REN95328 (e-PCR)
- UniSTS:420126

REN95329 (e-PCR)
- UniSTS:420127

REN95330 (e-PCR)
- UniSTS:420128

ECD02068 (e-PCR)
- UniSTS:283169

REN95331 (e-PCR)
- UniSTS:420129

REN95332 (e-PCR)
- UniSTS:420130

REN95333 (e-PCR)
- UniSTS:420131

REN95334 (e-PCR)
- UniSTS:420132

REN95335 (e-PCR)
- UniSTS:420133

REN95336 (e-PCR)
- UniSTS:420134

REN95337 (e-PCR)
- UniSTS:420135

REN95338 (e-PCR)
- UniSTS:420136

REN95339 (e-PCR)
- UniSTS:420137

REN95340 (e-PCR)
- UniSTS:420138

REN95341 (e-PCR)
- UniSTS:420139

REN95342 (e-PCR)
- UniSTS:420140

REN95343 (e-PCR)
- UniSTS:420141

REN95344 (e-PCR)
- UniSTS:420142

REN95345 (e-PCR)
- UniSTS:420143

REN95346 (e-PCR)
- UniSTS:420144

REN95347 (e-PCR)
- UniSTS:420145

REN95348 (e-PCR)
- UniSTS:420146

D8S2279 (e-PCR)
- UniSTS:473907

REN95349 (e-PCR)
- UniSTS:420147

REN95350 (e-PCR)
- UniSTS:420148

REN95351 (e-PCR)
- UniSTS:420149

REN95352 (e-PCR)
- UniSTS:420150

REN95353 (e-PCR)
- UniSTS:420151

REN95354 (e-PCR)
- UniSTS:420152

REN95355 (e-PCR)
- UniSTS:420153

REN95356 (e-PCR)
- UniSTS:420154

REN95357 (e-PCR)
- UniSTS:420155

REN95358 (e-PCR)
- UniSTS:420156

REN95359 (e-PCR)
- UniSTS:420157

REN95360 (e-PCR)
- UniSTS:420158

ECD03682 (e-PCR)
- UniSTS:284762

ECD11673 (e-PCR)
- UniSTS:292709

D16S2581E (e-PCR)
- UniSTS:151658

RH98690 (e-PCR)
- UniSTS:86952

ECD05311 (e-PCR)
- UniSTS:286377

ECD11496 (e-PCR)
- UniSTS:292532

ECD08202 (e-PCR)
- UniSTS:289250

stSG608991 (e-PCR)
- UniSTS:448488

stSG608993 (e-PCR)
- UniSTS:448490

NoName (e-PCR)
- UniSTS:486899

ECD03322 (e-PCR)
- UniSTS:284407

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G-protein beta-subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: regulator of G-protein signaling 11

Names: regulator of G-protein signalling 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001286485.2 → NP_001273414.1 regulator of G-protein signaling 11 isoform 3

See identical proteins and their annotated locations for NP_001273414.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate splice junction at the 3' end of a coding exon and lacks an alternate coding exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AB016929, AF035153, CK299324, DC423811, Z69667

Consensus CDS

CCDS66884.1

UniProtKB/Swiss-Prot

O94810

Related

ENSP00000352778.5, ENST00000359740.6

Conserved Domains (3) summary

smart00224
Location:212 → 273

GGL; G protein gamma subunit-like motifs

cd08740
Location:284 → 409

RGS_RGS11; Regulator of G protein signaling (RGS) domain found in the RGS11 protein

cd04450
Location:24 → 107

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
NM_001286486.2 → NP_001273415.1 regulator of G-protein signaling 11 isoform 4

See identical proteins and their annotated locations for NP_001273415.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate splice junction at the 3' end of the first exon and lacks two alternate exons compared to variant 1. The resulting isoform (4) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.

Source sequence(s)

AF035153, AK091701, CK299324, DC423811, Z69667

UniProtKB/Swiss-Prot

O94810

Conserved Domains (2) summary

smart00224
Location:39 → 100

GGL; G protein gamma subunit-like motifs

cd08740
Location:111 → 236

RGS_RGS11; Regulator of G protein signaling (RGS) domain found in the RGS11 protein
NM_003834.3 → NP_003825.1 regulator of G-protein signaling 11 isoform 2

See identical proteins and their annotated locations for NP_003825.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) includes an alternate segment, compared to variant 1. This results in translation initiation at a downstream AUG, and an isoform (2) with a shorter N-terminus compared to isoform 1.

Source sequence(s)

AF035154, CK299324, DC423811, Z69667

Consensus CDS

CCDS10403.1

UniProtKB/Swiss-Prot

O94810

Related

ENSP00000319069.5, ENST00000316163.9

Conserved Domains (3) summary

smart00224
Location:202 → 263

GGL; G protein gamma subunit-like motifs

cd08740
Location:274 → 399

RGS_RGS11; Regulator of G protein signaling (RGS) domain found in the RGS11 protein

cd04450
Location:3 → 90

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
NM_183337.3 → NP_899180.1 regulator of G-protein signaling 11 isoform 1

See identical proteins and their annotated locations for NP_899180.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AF035153, CK299324, DC423811, Z69667

Consensus CDS

CCDS42088.1

UniProtKB/Swiss-Prot

O75883, O94810, Q4TT71, Q4TT72

UniProtKB/TrEMBL

Q4TT70

Related

ENSP00000380876.3, ENST00000397770.8

Conserved Domains (3) summary

smart00224
Location:223 → 284

GGL; G protein gamma subunit-like motifs

cd08740
Location:295 → 420

RGS_RGS11; Regulator of G protein signaling (RGS) domain found in the RGS11 protein

cd04450
Location:24 → 111

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

268307..275944 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011522719.3 → XP_011521021.1 regulator of G-protein signaling 11 isoform X1

Conserved Domains (3) summary

smart00224
Location:255 → 316

GGL; G protein gamma subunit-like motifs

cd08740
Location:327 → 452

RGS_RGS11; Regulator of G protein signaling (RGS) domain found in the RGS11 protein

cd04450
Location:24 → 106

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
XM_011522720.3 → XP_011521022.1 regulator of G-protein signaling 11 isoform X2

Conserved Domains (3) summary

smart00224
Location:234 → 295

GGL; G protein gamma subunit-like motifs

cd08740
Location:306 → 431

RGS_RGS11; Regulator of G protein signaling (RGS) domain found in the RGS11 protein

cd04450
Location:3 → 85

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
XM_047434833.1 → XP_047290789.1 regulator of G-protein signaling 11 isoform X4
XM_047434832.1 → XP_047290788.1 regulator of G-protein signaling 11 isoform X3
XM_047434834.1 → XP_047290790.1 regulator of G-protein signaling 11 isoform X7
XM_011522723.2 → XP_011521025.1 regulator of G-protein signaling 11 isoform X8

See identical proteins and their annotated locations for XP_011521025.1

UniProtKB/TrEMBL

B7Z285

Conserved Domains (1) summary

cd04450
Location:24 → 111

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
XM_011522722.2 → XP_011521024.1 regulator of G-protein signaling 11 isoform X6

Conserved Domains (1) summary

cd04450
Location:24 → 106

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
XM_011522721.2 → XP_011521023.1 regulator of G-protein signaling 11 isoform X5

Conserved Domains (1) summary

cd04450
Location:24 → 106

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

Alternate T2T-CHM13v2.0

Genomic

NC_060940.1 Alternate T2T-CHM13v2.0

Range

263137..270775 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054314253.1 → XP_054170228.1 regulator of G-protein signaling 11 isoform X1
XM_054314254.1 → XP_054170229.1 regulator of G-protein signaling 11 isoform X2
XM_054314256.1 → XP_054170231.1 regulator of G-protein signaling 11 isoform X4
XM_054314255.1 → XP_054170230.1 regulator of G-protein signaling 11 isoform X3
XM_054314259.1 → XP_054170234.1 regulator of G-protein signaling 11 isoform X7
XM_054314260.1 → XP_054170235.1 regulator of G-protein signaling 11 isoform X8

UniProtKB/TrEMBL

B7Z285
XM_054314258.1 → XP_054170233.1 regulator of G-protein signaling 11 isoform X6
XM_054314257.1 → XP_054170232.1 regulator of G-protein signaling 11 isoform X5