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TRADD TNFRSF1A associated via death domain [ Homo sapiens (human) ]

Gene ID: 8717, updated on 11-Apr-2024

Summary

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Official Symbol
TRADDprovided by HGNC
Official Full Name
TNFRSF1A associated via death domainprovided by HGNC
Primary source
HGNC:HGNC:12030
See related
Ensembl:ENSG00000102871 MIM:603500; AllianceGenome:HGNC:12030
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Hs.89862
Summary
The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in stomach (RPKM 7.8), spleen (RPKM 7.4) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
16q22.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67154185..67159909, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (72948477..72954201, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67188088..67193812, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7576 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7577 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7578 Neighboring gene core-binding factor subunit beta Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67142676-67143418 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67143419-67144160 Neighboring gene phagosome assembly factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7580 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7581 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67189519-67190420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10952 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7584 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67195788-67196300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67196374-67197322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67197323-67198271 Neighboring gene Sharpr-MPRA regulatory region 11796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7588 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67206328-67206491 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67207408-67208330 Neighboring gene F-box and leucine rich repeat protein 8 Neighboring gene heat shock transcription factor 4 Neighboring gene microtubule associated tyrosine carboxypeptidase 1 Neighboring gene nucleolar protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Roles of the adaptor protein tumor necrosis factor receptor type 1-associated death domain protein (TRADD) in human diseases. Chen Y, et al. Biomed Pharmacother, 2022 Sep. PMID 36076575
  2. Structure of the C-terminal domain of TRADD reveals a novel fold in the death domain superfamily. Zhang N, et al. Sci Rep, 2017 Aug 1. PMID 28765645, Free PMC Article
  3. Identification of TRADD as a potential biomarker in human uterine leiomyoma through iTRAQ based proteomic profiling. Liu Y, et al. Mol Cell Probes, 2017 Dec. PMID 28698006
  4. Nuclear TRADD prevents DNA damage-mediated death by facilitating non-homologous end-joining repair. Koo GB, et al. Sci Rep, 2017 Jun 13. PMID 28611389, Free PMC Article
  5. Anticancer activity of an antisense oligonucleotide targeting TRADD combined with proteasome inhibitors in chemoresistant hepatocellular carcinoma cells. Witort E, et al. J Chemother, 2013 Oct. PMID 24070137

See all (168) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Roles of the adaptor protein tumor necrosis factor receptor type 1-associated death domain protein (TRADD) in human diseases.
    Title: Roles of the adaptor protein tumor necrosis factor receptor type 1-associated death domain protein (TRADD) in human diseases.
  2. RIPK1 and TRADD Regulate TNF-Induced Signaling and Ripoptosome Formation.
    Title: RIPK1 and TRADD Regulate TNF-Induced Signaling and Ripoptosome Formation.
  3. Structural basis of NF-kappaB signaling by the p75 neurotrophin receptor interaction with adaptor protein TRADD through their respective death domains.
    Title: Structural basis of NF-κB signaling by the p75 neurotrophin receptor interaction with adaptor protein TRADD through their respective death domains.
  4. Modulating TRADD to restore cellular homeostasis and inhibit apoptosis.
    Title: Modulating TRADD to restore cellular homeostasis and inhibit apoptosis.
  5. Coronin 1B regulates the TNFalpha-induced apoptosis of HUVECs by mediating the interaction between TRADD and FADD.
    Title: Coronin 1B regulates the TNFα-induced apoptosis of HUVECs by mediating the interaction between TRADD and FADD.
  6. SNHG9, delivered by adipocyte-derived exosomes, alleviates inflammation and apoptosis of endothelial cells through suppressing TRADD expression.
    Title: SNHG9, delivered by adipocyte-derived exosomes, alleviates inflammation and apoptosis of endothelial cells through suppressing TRADD expression.
  7. The TRADD C-terminal death domain comprises two super-secondary structures, an all-helix Greek key motif and a beta-hairpin motif flanked by two alpha helices, which make it unique among all known C-terminal death domain structures.
    Title: Structure of the C-terminal domain of TRADD reveals a novel fold in the death domain superfamily.
  8. Translocation of TRADD to DSBs into the nucleus contributes to cell survival in response to DNA damage through an activation of NHEJ DNA repair.
    Title: Nuclear TRADD prevents DNA damage-mediated death by facilitating non-homologous end-joining repair.
  9. potential biological significance of TRADD mediated inflammatory response in the development of uterine leiomyoma, is reported.
    Title: Identification of TRADD as a potential biomarker in human uterine leiomyoma through iTRAQ based proteomic profiling.
  10. we found that ORF3 protein downregulates TLR3-mediated NF-kappaB signaling via TRADD and RIP1. Our findings provide a new perspective on the cellular response in HEV infection and expand our understanding of the molecular mechanisms of Hepatitis E virus (HEV) pathogenesis in innate immunity.
    Title: The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1.
Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC11078

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables death domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein tyrosine kinase adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane receptor protein tyrosine kinase adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to tumor necrosis factor IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in extrinsic apoptotic signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in extrinsic apoptotic signaling pathway via death domain receptors TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of hair follicle development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic side of plasma membrane IC
Inferred by Curator
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of death-inducing signaling complex TAS
Traceable Author Statement
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of tumor necrosis factor receptor superfamily complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of tumor necrosis factor receptor superfamily complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tumor necrosis factor receptor type 1-associated DEATH domain protein
Names
TNFR1-associated death domain protein
tumor necrosis factor receptor type 1 associated death domain protein
tumor necrosis factor receptor-1-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001323552.2 → NP_001310481.1  tumor necrosis factor receptor type 1-associated DEATH domain protein

    Status: REVIEWED

    Source sequence(s)
    AC074143, BT006934, CA426418, DA353575
    Consensus CDS
    CCDS10829.1
    UniProtKB/Swiss-Prot
    B2RDS3, B3KQZ9, Q15628, Q52NZ1
    Conserved Domains (2) summary
    pfam09034
    Location:51 → 160
    TRADD_N; TRADD, N-terminal domain
    cl14633
    Location:215 → 304
    DD; Death Domain Superfamily of protein-protein interaction domains

  2. NM_003789.4 → NP_003780.1  tumor necrosis factor receptor type 1-associated DEATH domain protein

    See identical proteins and their annotated locations for NP_003780.1

    Status: REVIEWED

    Source sequence(s)
    BC004491, CA426418, DA353575
    Consensus CDS
    CCDS10829.1
    UniProtKB/Swiss-Prot
    B2RDS3, B3KQZ9, Q15628, Q52NZ1
    Related
    ENSP00000341268.4, ENST00000345057.9
    Conserved Domains (2) summary
    pfam09034
    Location:51 → 160
    TRADD_N; TRADD, N-terminal domain
    cl14633
    Location:215 → 304
    DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    67154185..67159909 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    72948477..72954201 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_153425.1: Suppressed sequence

    Description
    NM_153425.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript variant.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15628.2 GenPept UniProtKB/Swiss-Prot:Q15628

Gene LinkOut

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