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EIF3H eukaryotic translation initiation factor 3 subunit H [ Homo sapiens (human) ]

Gene ID: 8667, updated on 31-Mar-2024

Summary

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Official Symbol
EIF3Hprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 3 subunit Hprovided by HGNC
Primary source
HGNC:HGNC:3273
See related
Ensembl:ENSG00000147677 MIM:603912; AllianceGenome:HGNC:3273
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF3S3; eIF3-p40; eIF3-gamma
Summary
Enables deubiquitinase activity. Contributes to translation initiation factor activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process and translational initiation. Located in extracellular exosome and membrane. Part of eukaryotic translation initiation factor 3 complex. Implicated in breast cancer; prostate cancer; and prostate carcinoma. Biomarker of prostate cancer. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 170.8), thyroid (RPKM 126.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
8q23.3-q24.11
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (116642130..116766374, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (117769451..117883944, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (117654369..117768062, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375711 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:117543437-117543943 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:117595153-117596003 Neighboring gene uncharacterized LOC105375712 Neighboring gene Sharpr-MPRA regulatory region 10947 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27825 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27826 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27827 Neighboring gene uncharacterized LOC105375713 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27828 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:117690347-117691260 Neighboring gene NANOG hESC enhancer GRCh37_chr8:117702562-117703067 Neighboring gene NANOG hESC enhancer GRCh37_chr8:117742295-117742846 Neighboring gene uncharacterized LOC124902006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27830 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27831 Neighboring gene uncharacterized LOC112268030 Neighboring gene UTP23 small subunit processome component Neighboring gene RAD21 cohesin complex component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. EIF3H knockdown inhibits malignant melanoma through regulating cell proliferation, apoptosis and cell cycle. Zheng W, et al. Exp Cell Res, 2021 May 1. PMID 33508274
  2. Eukaryotic translation initiation factor EIF3H potentiates gastric carcinoma cell proliferation. Wang X, et al. Tissue Cell, 2018 Aug. PMID 30060823
  3. The proliferation of colorectal cancer cells is suppressed by silencing of EIF3H. Yu G, et al. Biosci Biotechnol Biochem, 2018 Oct. PMID 30022709
  4. Elevated expression of eukaryotic translation initiation factor 3H is associated with proliferation, invasion and tumorigenicity in human hepatocellular carcinoma. Zhu Q, et al. Oncotarget, 2016 Aug 2. PMID 27340783, Free PMC Article
  5. Allelic variation at the 8q23.3 colorectal cancer risk locus functions as a cis-acting regulator of EIF3H. Pittman AM, et al. PLoS Genet, 2010 Sep 16. PMID 20862326, Free PMC Article

See all (161) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The EIF3H-HAX1 axis increases RAF-MEK-ERK signaling activity to promote colorectal cancer progression.
    Title: The EIF3H-HAX1 axis increases RAF-MEK-ERK signaling activity to promote colorectal cancer progression.
  2. Repeat polymorphisms underlie top genetic risk loci for glaucoma and colorectal cancer.
    Title: Repeat polymorphisms underlie top genetic risk loci for glaucoma and colorectal cancer.
  3. The deubiquitinase EIF3H promotes hepatocellular carcinoma progression by stabilizing OGT and inhibiting ferroptosis.
    Title: The deubiquitinase EIF3H promotes hepatocellular carcinoma progression by stabilizing OGT and inhibiting ferroptosis.
  4. EIF3H stabilizes CCND1 to promotes intrahepatic cholangiocarcinoma progression via Wnt/beta-catenin signaling.
    Title: EIF3H stabilizes CCND1 to promotes intrahepatic cholangiocarcinoma progression via Wnt/β-catenin signaling.
  5. The effect of miR-496 on eIF3h in lung invasive adenocarcinoma.
    Title: The effect of miR-496 on eIF3h in lung invasive adenocarcinoma.
  6. EIF3H knockdown inhibits malignant melanoma through regulating cell proliferation, apoptosis and cell cycle.
    Title: EIF3H knockdown inhibits malignant melanoma through regulating cell proliferation, apoptosis and cell cycle.
  7. EIF3H promotes aggressiveness of esophageal squamous cell carcinoma by modulating Snail stability.
    Title: EIF3H promotes aggressiveness of esophageal squamous cell carcinoma by modulating Snail stability.
  8. EIF3H Orchestrates Hippo Pathway-Mediated Oncogenesis via Catalytic Control of YAP Stability.
    Title: EIF3H Orchestrates Hippo Pathway-Mediated Oncogenesis via Catalytic Control of YAP Stability.
  9. METTL3-eIF3h interaction is required for enhanced translation, formation of densely packed polyribosomes and oncogenic transformation; findings uncover a mechanism of translation control that is based on mRNA looping and identify METTL3-eIF3h as a potential therapeutic target for patients with cancer
    Title: mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis.
  10. EIF3H knockdown inhibited cell proliferation and colony formation in gastric cancer lines and led to cell cycle arrest at the G0/G1 phase, while inducing apoptosis via up- and downregulation of pro- and anti-apoptotic factors, respectively. These results indicate that EIF3H can serve as a novel therapeutic target for the clinical treatment of gastric cancer.
    Title: Eukaryotic translation initiation factor EIF3H potentiates gastric carcinoma cell proliferation.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.
EBI GWAS Catalog
A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine.
EBI GWAS Catalog
Genetic variants near PDGFRA are associated with corneal curvature in Australians.
EBI GWAS Catalog
Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.
EBI GWAS Catalog
Meta-analysis of new genome-wide association studies of colorectal cancer risk.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of eukaryotic translation initiation factor 3, subunit H (EIF3H) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit H (EIF3H) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies translation regulatory and RNA binding proteins eIF3h, eEF1A-1, and hnRNPA2 as IN-binding partners PubMed
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit H (EIF3H) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102958

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables metal-dependent deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metallopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to translation initiation factor activity IC
Inferred by Curator
more info
 PubMed 
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in formation of cytoplasmic translation initiation complex NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of translational initiation TAS
Traceable Author Statement
more info
 PubMed 
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation IC
Inferred by Curator
more info
 PubMed 
involved_in translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of eukaryotic 43S preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic translation initiation factor 3 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of eukaryotic translation initiation factor 3 complex, eIF3m IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
located_in membrane HDA PubMed 

General protein information

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Preferred Names
eukaryotic translation initiation factor 3 subunit H
Names
eIF-3-gamma
eIF3 p40 subunit
eukaryotic translation initiation factor 3 subunit 3
eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD)
eukaryotic translation initiation factor 3, subunit 3 (gamma, 40kD)
eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003756.3 → NP_003747.1  eukaryotic translation initiation factor 3 subunit H

    See identical proteins and their annotated locations for NP_003747.1

    Status: VALIDATED

    Source sequence(s)
    AA902770, AC023520, AU117206, U54559
    Consensus CDS
    CCDS6319.1
    UniProtKB/Swiss-Prot
    O15372
    UniProtKB/TrEMBL
    Q53HG0, Q53HR0, Q6IB98
    Related
    ENSP00000429931.1, ENST00000521861.6
    Conserved Domains (1) summary
    cd08065
    Location:37 → 300
    MPN_eIF3h; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF2h

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    116642130..116766374 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422386.1 → XP_047278342.1  eukaryotic translation initiation factor 3 subunit H isoform X1

  2. XM_047422384.1 → XP_047278340.1  eukaryotic translation initiation factor 3 subunit H isoform X1

  3. XM_047422385.1 → XP_047278341.1  eukaryotic translation initiation factor 3 subunit H isoform X1

  4. XM_047422383.1 → XP_047278339.1  eukaryotic translation initiation factor 3 subunit H isoform X1

  5. XM_047422380.1 → XP_047278336.1  eukaryotic translation initiation factor 3 subunit H isoform X1

  6. XM_047422382.1 → XP_047278338.1  eukaryotic translation initiation factor 3 subunit H isoform X1

  7. XM_047422381.1 → XP_047278337.1  eukaryotic translation initiation factor 3 subunit H isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    117769451..117883944 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15372.1 GenPept UniProtKB/Swiss-Prot:O15372

Gene LinkOut

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