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EIF3G eukaryotic translation initiation factor 3 subunit G [ Homo sapiens (human) ]

Gene ID: 8666, updated on 7-Apr-2024

Summary

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Official Symbol
EIF3Gprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 3 subunit Gprovided by HGNC
Primary source
HGNC:HGNC:3274
See related
Ensembl:ENSG00000130811 MIM:603913; AllianceGenome:HGNC:3274
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF3S4; EIF3-P42; eIF3-p44; eIF3-delta
Summary
This gene encodes a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is required for initiation of protein translation. An N-terminal caspase cleavage product of the encoded protein may stimulate degradation of DNA. A mutation in this gene is associated with narcolepsy. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in ovary (RPKM 90.1), testis (RPKM 63.4) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
19p13.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (10115014..10119899, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (10241223..10246106, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10225690..10230575, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PPAN-P2RY11 readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10218607-10219250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10220162-10220743 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13939 Neighboring gene Sharpr-MPRA regulatory region 3609 Neighboring gene small nucleolar RNA, C/D box 105 Neighboring gene small nucleolar RNA, C/D box 105B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10229321-10230077 Neighboring gene peter pan homolog Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10230078-10230833 Neighboring gene purinergic receptor P2Y11 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:10243570-10243866 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:10246117-10247316 Neighboring gene DNA methyltransferase 1 Neighboring gene origin of replication in DNMT1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10294611-10295111 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10057 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13940 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10310838-10311338 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 10 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition. Simonetti A, et al. Mol Cell, 2016 Jul 21. PMID 27373335
  2. Nuclear distribution of eIF3g and its interacting nuclear proteins in breast cancer cells. Zheng Q, et al. Mol Med Rep, 2016 Apr. PMID 26935993, Free PMC Article
  3. EIF3G is associated with narcolepsy across ethnicities. Holm A, et al. Eur J Hum Genet, 2015 Nov. PMID 25669430, Free PMC Article
  4. Caspase-mediated cleavage and DNase activity of the translation initiation factor 3, subunit G (eIF3g). Kim JT, et al. FEBS Lett, 2013 Nov 15. PMID 24080033
  5. Translation initiation on mRNAs bound by nuclear cap-binding protein complex CBP80/20 requires interaction between CBP80/20-dependent translation initiation factor and eukaryotic translation initiation factor 3g. Choe J, et al. J Biol Chem, 2012 May 25. PMID 22493286, Free PMC Article

See all (158) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An interaction between eIF4A3 and eIF3g drives the internal initiation of translation.
    Title: An interaction between eIF4A3 and eIF3g drives the internal initiation of translation.
  2. In vitro reconstitution of SARS-CoV-2 Nsp1-induced mRNA cleavage reveals the key roles of the N-terminal domain of Nsp1 and the RRM domain of eIF3g.
    Title: In vitro reconstitution of SARS-CoV-2 Nsp1-induced mRNA cleavage reveals the key roles of the N-terminal domain of Nsp1 and the RRM domain of eIF3g.
  3. The disease-associated allele increases EIF3G mRNA expression. EIF3G is located in the narcolepsy risk locus and EIF3G expression correlates with PPAN and P2RY11 expression.
    Title: EIF3G is associated with narcolepsy across ethnicities.
  4. Important roles for eIF3g in the translation initiation machinery and in DNA degradation during apoptosis.
    Title: Caspase-mediated cleavage and DNase activity of the translation initiation factor 3, subunit G (eIF3g).
  5. down-regulation of eIF3g inhibits the efficiency of nonsense-mediated mRNA decay, which is tightly coupled to CT but not to ET
    Title: Translation initiation on mRNAs bound by nuclear cap-binding protein complex CBP80/20 requires interaction between CBP80/20-dependent translation initiation factor and eukaryotic translation initiation factor 3g.
  6. PELO is subcellularly localized at the actin cytoskeleton, interacts with HAX1, EIF3G and SRPX proteins and that this interaction occurs at the cytoskeleton; this interaction may facilitate PELO to detect and degrade aberrant mRNAs.
    Title: Pelota interacts with HAX1, EIF3G and SRPX and the resulting protein complexes are associated with the actin cytoskeleton.
  7. Furthermore, we found that overexpression of DISC1 in SH-SY5Y cells induces the assembly of eIF3- and TIA-1-positive stress granules (SGs), discrete cytoplasmic granules formed in response to environmental stresses.
    Title: A functional link between Disrupted-In-Schizophrenia 1 and the eukaryotic translation initiation factor 3.
  8. AIF overexpression specifically resulted in the activation of caspase-7, thereby amplifying the inhibition of protein
    Title: Apoptosis-inducing factor (AIF) inhibits protein synthesis by interacting with the eukaryotic translation initiation factor 3 subunit p44 (eIF3g).
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit G (EIF3G) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to translation initiation factor activity IC
Inferred by Curator
more info
 PubMed 
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in formation of cytoplasmic translation initiation complex NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translational initiation IC
Inferred by Curator
more info
 PubMed 
involved_in translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in viral translational termination-reinitiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic translation initiation factor 3 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
NOT located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 3 subunit G
Names
eukaryotic translation initiation factor 3 RNA-binding subunit
eukaryotic translation initiation factor 3 subunit p42
eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051197.1 RefSeqGene

    Range
    5026..9911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003755.5 → NP_003746.2  eukaryotic translation initiation factor 3 subunit G

    See identical proteins and their annotated locations for NP_003746.2

    Status: REVIEWED

    Source sequence(s)
    AA588881, BC000733
    Consensus CDS
    CCDS12227.1
    UniProtKB/Swiss-Prot
    O14801, O75821, Q969U5
    UniProtKB/TrEMBL
    A8K5K5, Q6IAM0
    Related
    ENSP00000253108.3, ENST00000253108.9
    Conserved Domains (2) summary
    cd12933
    Location:62 → 173
    eIF3G; eIF3G domain found in eukaryotic translation initiation factor 3 subunit G (eIF-3G) and similar proteins
    cd12408
    Location:240 → 315
    RRM_eIF3G_like; RNA recognition motif (RRM) found in eukaryotic translation initiation factor 3 subunit G (eIF-3G) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    10115014..10119899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    10241223..10246106 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75821.2 GenPept UniProtKB/Swiss-Prot:O75821

Gene LinkOut

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