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EIF3C eukaryotic translation initiation factor 3 subunit C [ Homo sapiens (human) ]

Gene ID: 8663, updated on 7-Apr-2024

Summary

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Official Symbol
EIF3Cprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 3 subunit Cprovided by HGNC
Primary source
HGNC:HGNC:3279
See related
Ensembl:ENSG00000184110 MIM:603916; AllianceGenome:HGNC:3279
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF3CL; EIF3S8; eIF3-p110
Summary
Enables ribosome binding activity. Contributes to translation initiation factor activity. Involved in positive regulation of mRNA binding activity; positive regulation of translation; and translational initiation. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 96.4), thyroid (RPKM 93.0) and 25 other tissues See more
Orthologs
all
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Genomic context

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See EIF3C in Genome Data Viewer
Location:
16p11.2
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (28688558..28735730)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (28969279..29016311)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28699879..28747051)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene nuclear pore complex interacting protein family member B8 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28677654-28678567 Neighboring gene small nucleolar RNA U13 Neighboring gene cell division cycle 37 pseudogene 1 Neighboring gene microRNA 6862-2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28742791-28743343 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28751627-28752170 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28752171-28752713 Neighboring gene uncharacterized LOC124903761 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28770347-28770847 Neighboring gene pro-apoptotic WT1 regulator pseudogene 2 Neighboring gene nuclear pore complex interacting protein family member B9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Upregulated expression of eIF3C is associated with malignant behavior in renal cell carcinoma. Fan M, et al. Int J Oncol, 2019 Dec. PMID 31638200
  2. Eukaryotic initiation factor 3, subunit C silencing inhibits cell proliferation and promotes apoptosis in human ovarian cancer cells. Wen F, et al. Biosci Rep, 2019 Aug 30. PMID 31316002, Free PMC Article
  3. The Prognostic Significance of EIF3C Gene during the Tumorigenesis of Prostate Cancer. Hu J, et al. Cancer Invest, 2019. PMID 31181967
  4. Transcriptomic analyses of RNA-binding proteins reveal eIF3c promotes cell proliferation in hepatocellular carcinoma. Li T, et al. Cancer Sci, 2017 May. PMID 28231410, Free PMC Article
  5. Eukaryotic initiation factor 3C silencing inhibits cell proliferation and promotes apoptosis in human glioma. Hao J, et al. Oncol Rep, 2015 Jun. PMID 25823503

See all (180) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Complement factor H attenuates TNF-alpha-induced inflammation by upregulating EIF3C in rheumatoid arthritis.
    Title: Complement factor H attenuates TNF-α-induced inflammation by upregulating EIF3C in rheumatoid arthritis.
  2. circPDE5A regulates prostate cancer metastasis via controlling WTAP-dependent N6-methyladenisine methylation of EIF3C mRNA.
    Title: circPDE5A regulates prostate cancer metastasis via controlling WTAP-dependent N6-methyladenisine methylation of EIF3C mRNA.
  3. Human oncoprotein 5MP suppresses general and repeat-associated non-AUG translation via eIF3 by a common mechanism.
    Title: Human oncoprotein 5MP suppresses general and repeat-associated non-AUG translation via eIF3 by a common mechanism.
  4. ZNF280A promotes lung adenocarcinoma development by regulating the expression of EIF3C.
    Title: ZNF280A promotes lung adenocarcinoma development by regulating the expression of EIF3C.
  5. Eukaryotic initiation factor 3, subunit C silencing inhibits cell proliferation and promotes apoptosis in human ovarian cancer cells.
    Title: Eukaryotic initiation factor 3, subunit C silencing inhibits cell proliferation and promotes apoptosis in human ovarian cancer cells.
  6. circ_0067934 promotes cervical cancer progression via miR-545/EIF3C axis.
    Title: Overexpressed circ_0067934 acts as an oncogene to facilitate cervical cancer progression via the miR-545/EIF3C axis.
  7. eIF3C expression was upregulated in renal cell carcinoma (RCC) tissues and cell lines. Depletion of eIF3C reduced tumor cell proliferation and arrested them at the G1 stage, thus promoting their apoptosis in vitro. Depletion of eIF3C also inhibited the formation and growth of tumor cell xenografts in nude mice. Study demonstrated that upregulated eIF3C expression contributed to the development and progression of RCC.
    Title: Upregulated expression of eIF3C is associated with malignant behavior in renal cell carcinoma.
  8. Whereas the eIF3c knockdown reduces it, downregulation of eIF3k or eIF3l increases mRNA recruitment, suggesting that the latter subunits possess a regulatory potential. Altogether this study provides new insights into the role of human eIF3 in the initial assembly steps of the translational machinery
    Title: Adapted formaldehyde gradient cross-linking protocol implicates human eIF3d and eIF3c, k and l subunits in the 43S and 48S pre-initiation complex assembly, respectively.
  9. EIF3C overexpression was correlated to age and tumor stage in prostate cancer patients and indicated poor survival. The proliferation, migration, and invasiveness of PC3 cells were all inhibited after EIF3C knockdown. Phosphorylation level of PI3K and Akt and total NF-kappaB and Myc decreased after EIF3C knockdown. Therefore, EIF3C at least partially regulates the activity of PI3K/Akt/NF-kappaB signaling pathway in PC3...
    Title: The Prognostic Significance of EIF3C Gene during the Tumorigenesis of Prostate Cancer.
  10. In EIF3C-positive tumors, 32 out of 42 showed significantly higher frequencies of high grade group by immunoreactivity.
    Title: Decreasing Eukaryotic Initiation Factor 3C (EIF3C) Suppresses Proliferation and Stimulates Apoptosis in Breast Cancer Cell Lines Through Mammalian Target of Rapamycin (mTOR) Pathway.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common variants at five new loci associated with early-onset inflammatory bowel disease.
EBI GWAS Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit C (EIF3C) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit C (EIF3C) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ53378, FLJ54400, FLJ54404, FLJ55450, FLJ55750, FLJ78287, MGC189737, MGC189744

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to translation initiation factor activity IC
Inferred by Curator
more info
 PubMed 
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation initiation factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in formation of cytoplasmic translation initiation complex NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of mRNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in positive regulation of translation IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation IC
Inferred by Curator
more info
 PubMed 
involved_in translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic translation initiation factor 3 complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic translation initiation factor 3 subunit C
Names
cell migration-inducing protein 17
eIF3 p110
eukaryotic translation initiation factor 3 subunit 8
eukaryotic translation initiation factor 3, subunit 8 (110kD)
eukaryotic translation initiation factor 3, subunit 8, 110kDa

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037808.2 → NP_001032897.1  eukaryotic translation initiation factor 3 subunit C isoform a

    See identical proteins and their annotated locations for NP_001032897.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    AC145285, AL045958, BC001571, BC071705, DC341554
    Consensus CDS
    CCDS10638.1
    UniProtKB/Swiss-Prot
    A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98
    UniProtKB/TrEMBL
    A1KYQ7
    Related
    ENSP00000378953.1, ENST00000395587.5
    Conserved Domains (2) summary
    smart00088
    Location:778 → 866
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam05470
    Location:29 → 705
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus

  2. NM_001199142.1 → NP_001186071.1  eukaryotic translation initiation factor 3 subunit C isoform a

    See identical proteins and their annotated locations for NP_001186071.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    AA679705, AK292155
    Consensus CDS
    CCDS10638.1
    UniProtKB/Swiss-Prot
    A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98
    UniProtKB/TrEMBL
    A1KYQ7
    Related
    ENSP00000457963.1, ENST00000566501.5
    Conserved Domains (2) summary
    smart00088
    Location:778 → 866
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam05470
    Location:29 → 705
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus

  3. NM_001267574.2 → NP_001254503.1  eukaryotic translation initiation factor 3 subunit C isoform a

    See identical proteins and their annotated locations for NP_001254503.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    AC145285, AK000739, AL045958, BC001571, DC341554
    Consensus CDS
    CCDS10638.1
    UniProtKB/Swiss-Prot
    A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98
    UniProtKB/TrEMBL
    A1KYQ7
    Related
    ENSP00000457418.1, ENST00000566866.5
    Conserved Domains (2) summary
    smart00088
    Location:778 → 866
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam05470
    Location:29 → 705
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus

  4. NM_001286478.1 → NP_001273407.1  eukaryotic translation initiation factor 3 subunit C isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC145285, AK303790, BC001571, DC341554
    Consensus CDS
    CCDS66993.1
    UniProtKB/TrEMBL
    A1KYQ7
    Related
    ENSP00000456416.1, ENST00000564243.5
    Conserved Domains (2) summary
    smart00753
    Location:768 → 856
    PAM; PCI/PINT associated module
    pfam05470
    Location:29 → 695
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus

  5. NM_003752.5 → NP_003743.1  eukaryotic translation initiation factor 3 subunit C isoform a

    See identical proteins and their annotated locations for NP_003743.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the predominant transcript. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    BC001571, DC341554
    Consensus CDS
    CCDS10638.1
    UniProtKB/Swiss-Prot
    A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98
    UniProtKB/TrEMBL
    A1KYQ7
    Related
    ENSP00000332604.7, ENST00000331666.11
    Conserved Domains (2) summary
    smart00088
    Location:778 → 866
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam05470
    Location:29 → 705
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    28688558..28735730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434828.1 → XP_047290784.1  eukaryotic translation initiation factor 3 subunit C isoform X1

    UniProtKB/Swiss-Prot
    A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98

  2. XM_047434827.1 → XP_047290783.1  eukaryotic translation initiation factor 3 subunit C isoform X1

    UniProtKB/Swiss-Prot
    A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98

  3. XM_017023814.3 → XP_016879303.1  eukaryotic translation initiation factor 3 subunit C isoform X2

    UniProtKB/TrEMBL
    A1KYQ7

  4. XM_047434829.1 → XP_047290785.1  eukaryotic translation initiation factor 3 subunit C isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    28969279..29016311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314249.1 → XP_054170224.1  eukaryotic translation initiation factor 3 subunit C isoform X1

    UniProtKB/Swiss-Prot
    A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98

  2. XM_054314250.1 → XP_054170225.1  eukaryotic translation initiation factor 3 subunit C isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99613.1 GenPept UniProtKB/Swiss-Prot:Q99613

Gene LinkOut

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