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PLPP2 phospholipid phosphatase 2 [ Homo sapiens (human) ]

Gene ID: 8612, updated on 10-Dec-2024

Summary

Official Symbol
PLPP2provided by HGNC
Official Full Name
phospholipid phosphatase 2provided by HGNC
Primary source
HGNC:HGNC:9230
See related
Ensembl:ENSG00000141934 MIM:607126; AllianceGenome:HGNC:9230
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPP2; PAP-2c; PAP2-g; PPAP2C
Summary
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Expression
Broad expression in gall bladder (RPKM 23.7), duodenum (RPKM 23.0) and 17 other tissues See more
Orthologs
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Genomic context

See PLPP2 in Genome Data Viewer
Location:
19p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (281043..291403, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (232088..242448, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (281043..291403, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928344 Neighboring gene uncharacterized LOC107985295 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13552 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9596 Neighboring gene MPRA-validated peak3201 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:278731-279381 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:281525-282216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:282217-282907 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:287125-287626 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:287627-288126 Neighboring gene vomeronasal 2 receptor 11 pseudogene Neighboring gene hESC enhancers GRCh37_chr19:289901-290599 and GRCh37_chr19:290600-291297 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:293997-294846 Neighboring gene uncharacterized LOC124904605 Neighboring gene MPRA-validated peak3203 silencer Neighboring gene MIER family member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:327661-328161 Neighboring gene MPRA-validated peak3205 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:341127-341714 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:342901-343852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9597 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9598 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9599

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in caveola PubMed 
located_in early endosome PubMed 
located_in early endosome membrane  
located_in endoplasmic reticulum PubMed 
located_in endoplasmic reticulum membrane  
located_in membrane PubMed 
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  

General protein information

Preferred Names
phospholipid phosphatase 2
Names
PAP2-gamma
PAP2c
lipid phosphate phosphohydrolase 2
phosphatidate phosphohydrolase type 2c
phosphatidic acid phosphatase 2c
phosphatidic acid phosphatase type 2C
phosphatidic acid phosphohydrolase type 2c
type-2 phosphatidic acid phosphatase-gamma
NP_003703.1
NP_803545.1
NP_808211.1
XP_011526698.1
XP_054178446.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003712.4NP_003703.1  phospholipid phosphatase 2 isoform 1

    See identical proteins and their annotated locations for NP_003703.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' region, including the 5' UTR and 5' coding region, as compared to variant 3. The resulting isoform (1) has a distinct and shorter N-terminus, as compared to isoform 3.
    Source sequence(s)
    AA428937, AF047760, BM050291, BM982485
    Consensus CDS
    CCDS12023.1
    UniProtKB/Swiss-Prot
    A6NLV0, E9PAY8, O43688
    Related
    ENSP00000388565.2, ENST00000434325.7
    Conserved Domains (1) summary
    cd03384
    Location:94240
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
  2. NM_177526.3NP_803545.1  phospholipid phosphatase 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' terminal exon, which results in a downstream translation start codon, as compared to variant 3. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 3.
    Source sequence(s)
    AA428937, BC002806, BM050291, BM982485, HY160303
    Consensus CDS
    CCDS45889.1
    UniProtKB/TrEMBL
    A0A0J9YXA3
    Related
    ENSP00000269812.2, ENST00000269812.7
    Conserved Domains (1) summary
    cd03384
    Location:38184
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
  3. NM_177543.3NP_808211.1  phospholipid phosphatase 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AA428937, AF047760, BE615792, BG831889, BM982485
    Consensus CDS
    CCDS12024.1
    UniProtKB/Swiss-Prot
    O43688
    Related
    ENSP00000329697.1, ENST00000327790.7
    Conserved Domains (1) summary
    cd03384
    Location:115261
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    281043..291403 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528396.3XP_011526698.1  phospholipid phosphatase 2 isoform X1

    Conserved Domains (1) summary
    cd03384
    Location:100246
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    232088..242448 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322471.1XP_054178446.1  phospholipid phosphatase 2 isoform X1

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