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PRE1 proteasome core particle subunit beta 4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856731, updated on 5-May-2024

Summary

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Gene symbol
PRE1
Gene description
proteasome core particle subunit beta 4
Primary source
SGD:S000000814
Locus tag
YER012W
See related
AllianceGenome:SGD:S000000814
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables endopeptidase activator activity. Involved in proteasomal ubiquitin-independent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum membrane and nucleus. Part of proteasome core complex, beta-subunit complex. Orthologous to human PSMB2 (proteasome 20S subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (177835..178431)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene GPI-anchored mannoprotein Neighboring gene tRNA-Glu Neighboring gene DEAH-box ATP-dependent RNA helicase PRP22 Neighboring gene oxygen-dependent protoporphyrinogen oxidase Neighboring gene Bud25p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proteinase yscE, the yeast proteasome/multicatalytic-multifunctional proteinase: mutants unravel its function in stress induced proteolysis and uncover its necessity for cell survival. Heinemeyer W, et al. EMBO J, 1991 Mar. PMID 2001673, Free PMC Article
  2. Proteasome inhibition enhances resistance to DNA damage via upregulation of Rpn4-dependent DNA repair genes. Karpov DS, et al. FEBS Lett, 2013 Sep 17. PMID 23954292
  3. Disruption of Rpn4-induced proteasome expression in Saccharomyces cerevisiae reduces cell viability under stressed conditions. Wang X, et al. Genetics, 2008 Dec. PMID 18832351, Free PMC Article
  4. Mutations in the yeast proteasome beta-type subunit Pre3 uncover position-dependent effects on proteasomal peptidase activity and in vivo function. Gueckel R, et al. J Biol Chem, 1998 Jul 31. PMID 9677364
  5. Proteasome-dependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fate. Werner ED, et al. Proc Natl Acad Sci U S A, 1996 Nov 26. PMID 8943015, Free PMC Article

See all (149) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables endopeptidase activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteasomal protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasomal ubiquitin-independent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteasomal ubiquitin-independent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex, beta-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome core complex, beta-subunit complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
proteasome core particle subunit beta 4
NP_010928.1
  • Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    177835..178431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178903.1 → NP_010928.1  TPA: proteasome core particle subunit beta 4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010928.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLQ9, P22141
    UniProtKB/TrEMBL
    A0A6A5Q0W2, A6ZQV9, B3LS24, B5VHE3, C7GKJ0, C8Z712, G2WCP3, N1PA82
    Conserved Domains (1) summary
    cd03758
    Location:1 → 194
    proteasome_beta_type_2; proteasome beta type-2 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
1G65_J.1
1G65_X.1
3JCO_6.1
3JCO_k.1
3JCP_6.1
3JCP_k.1
3OEU_J.1
3OEU_X.1
3OEV_J.1
3OEV_X.1
3SDI_J.1
3SDI_X.1
3SDK_J.1
3SDK_X.1
3SHJ_J.1
3SHJ_X.1
3TDD_J.1
3TDD_X.1
3UN4_J.1
3UN4_X.1
3UN8_J.1
3UN8_X.1
4EU2_K.1
4EU2_Y.1
4FZC_J.1
4FZC_X.1
4FZG_J.1
4FZG_X.1
4G4S_K.1
4GK7_J.1
4GK7_X.1
4HRC_J.1
4HRC_X.1
4HRD_J.1
4HRD_X.1
4JSQ_J.1
4JSQ_X.1
4JSU_J.1
4JSU_X.1
4JT0_J.1
4JT0_X.1
4LTC_J.1
4LTC_X.1
4NNN_J.1
4NNN_X.1
4NNW_J.1
4NNW_X.1
4NO1_J.1
4NO1_X.1
4NO6_J.1
4NO6_X.1
4NO8_J.1
4NO8_X.1
4NO9_J.1
4NO9_X.1
4Q1S_J.1
4Q1S_X.1
4QBY_J.1
4QBY_X.1
4QLQ_J.1
4QLQ_X.1
4QLS_J.1
4QLS_X.1
4QLT_J.1
4QLT_X.1
4QLU_J.1
4QLU_X.1
4QLV_J.1
4QLV_X.1
4QUX_J.1
4QUX_X.1
4QUY_J.1
4QUY_X.1
4QV0_J.1
4QV0_X.1
4QV1_J.1
4QV1_X.1
4QV3_J.1
4QV3_X.1
4QV4_J.1
4QV4_X.1
4QV5_J.1
4QV5_X.1
4QV6_J.1
4QV6_X.1
4QV7_J.1
4QV7_X.1
4QV8_J.1
4QV8_X.1
4QV9_J.1
4QV9_X.1
4QVL_J.1
4QVL_X.1
4QVM_J.1
4QVM_X.1
4QVN_J.1
4QVN_X.1
4QVP_J.1
4QVP_X.1
4QVQ_J.1
4QVQ_X.1
4QVV_J.1
4QVV_X.1
4QVW_J.1
4QVW_X.1
4QVY_J.1
4QVY_X.1
4QW0_J.1
4QW0_X.1
4QW1_J.1
4QW1_X.1
4QW3_J.1
4QW3_X.1
4QW4_J.1
4QW4_X.1
4QW5_J.1
4QW5_X.1
4QW6_J.1
4QW6_X.1
4QW7_J.1
4QW7_X.1
4QWF_J.1
4QWF_X.1
4QWG_J.1
4QWG_X.1
4QWI_J.1
4QWI_X.1
4QWJ_J.1
4QWJ_X.1
4QWK_J.1
4QWK_X.1
4QWL_J.1
4QWL_X.1
4QWR_J.1
4QWR_X.1
4QWS_J.1
4QWS_X.1
4QWU_J.1
4QWU_X.1
4QWX_J.1
4QWX_X.1
4QXJ_J.1
4QXJ_X.1
4QZ0_J.1
4QZ0_X.1
4QZ1_J.1
4QZ1_X.1
4QZ2_J.1
4QZ2_X.1
4QZ3_J.1
4QZ3_X.1
4QZ4_J.1
4QZ4_X.1
4QZ5_J.1
4QZ5_X.1
4QZ6_J.1
4QZ6_X.1
4QZ7_J.1
4QZ7_X.1
4QZW_J.1
4QZW_X.1
4QZX_J.1
4QZX_X.1
4QZZ_J.1
4QZZ_X.1
4R00_J.1
4R00_X.1
4R02_J.1
4R02_X.1
4R17_J.1
4R17_X.1
4R18_J.1
4R18_X.1
4RUR_J.1
4RUR_X.1
4X6Z_K.1
4X6Z_Y.1
4Y69_J.1
4Y69_X.1
4Y6A_J.1
4Y6A_X.1
4Y6V_J.1
4Y6V_X.1
4Y6Z_J.1
4Y6Z_X.1
4Y70_J.1
4Y70_X.1
4Y74_J.1
4Y74_X.1
4Y75_J.1
4Y75_X.1
4Y77_J.1
4Y77_X.1
4Y78_J.1
4Y78_X.1
4Y7W_J.1
4Y7W_X.1
4Y7X_J.1
4Y7X_X.1
4Y7Y_J.1
4Y7Y_X.1
4Y80_J.1
4Y80_X.1
4Y81_J.1
4Y81_X.1
4Y82_J.1
4Y82_X.1
4Y84_J.1
4Y84_X.1
4Y8G_J.1
4Y8G_X.1
4Y8H_J.1
4Y8H_X.1
4Y8I_J.1
4Y8I_X.1
4Y8J_J.1
4Y8J_X.1
4Y8K_J.1
4Y8K_X.1
4Y8L_J.1
4Y8L_X.1
4Y8M_J.1
4Y8M_X.1
4Y8N_J.1
4Y8N_X.1
4Y8O_J.1
4Y8O_X.1
4Y8P_J.1
4Y8P_X.1
4Y8Q_J.1
4Y8Q_X.1
4Y8R_J.1
4Y8R_X.1
4Y8S_J.1
4Y8S_X.1
4Y8T_J.1
4Y8T_X.1
4Y8U_J.1
4Y8U_X.1
4Y9Y_J.1
4Y9Y_X.1
4Y9Z_J.1
4Y9Z_X.1
4YA0_J.1
4YA0_X.1
4YA1_J.1
4YA1_X.1
4YA2_J.1
4YA2_X.1
4YA3_J.1
4YA3_X.1
4YA4_J.1
4YA4_X.1
4YA5_J.1
4YA5_X.1
4YA7_J.1
4YA7_X.1
4YA9_J.1
4YA9_X.1
4Z1L_J.1
4Z1L_X.1
5BOU_J.1
5BOU_X.1
5BXL_J.1
5BXL_X.1
5BXN_J.1
5BXN_X.1
5CGF_J.1
5CGF_X.1
5CGG_J.1
5CGG_X.1
5CGH_J.1
5CGH_X.1
5CGI_J.1
5CGI_X.1
5CZ4_J.1
5CZ4_X.1
5CZ5_J.1
5CZ5_X.1
5CZ6_J.1
5CZ6_X.1
5CZ7_J.1
5CZ7_X.1
5CZ8_J.1
5CZ8_X.1
5CZ9_J.1
5CZ9_X.1
5CZA_J.1
5CZA_X.1
5D0S_J.1
5D0S_X.1
5D0T_J.1
5D0T_X.1
5D0V_J.1
5D0V_X.1
5D0W_J.1
5D0W_X.1
5D0X_J.1
5D0X_X.1
5D0Z_J.1
5D0Z_X.1
5DKI_J.1
5DKI_X.1
5DKJ_J.1
5DKJ_X.1
5FG7_J.1
5FG7_X.1
5FG9_J.1
5FG9_X.1
5FGA_J.1
5FGA_X.1
5FGD_J.1
5FGD_X.1
5FGE_J.1
5FGE_X.1
5FGF_J.1
5FGF_X.1
5FGG_J.1
5FGG_X.1
5FGH_J.1
5FGH_X.1
5FGI_J.1
5FGI_X.1
5FHS_J.1
5FHS_X.1
5JHR_J.1
5JHR_X.1
5JHS_J.1
5JHS_X.1
5L52_J.1
5L52_X.1
5L54_J.1
5L54_X.1
5L55_J.1
5L55_X.1
5L5A_J.1
5L5A_X.1
5L5B_J.1
5L5B_X.1
5L5D_J.1
5L5D_X.1
5L5E_J.1
5L5E_X.1
5L5F_J.1
5L5F_X.1
5L5H_J.1
5L5H_X.1
5L5I_J.1
5L5I_X.1
5L5J_J.1
5L5J_X.1
5L5O_J.1
5L5O_X.1
5L5P_J.1
5L5P_X.1
5L5Q_J.1
5L5Q_X.1
5L5R_J.1
5L5R_X.1
5L5S_J.1
5L5S_X.1
5L5T_J.1
5L5T_X.1
5L5U_J.1
5L5U_X.1
5L5V_J.1
5L5V_X.1
5L5W_J.1
5L5W_X.1
5L5X_J.1
5L5X_X.1
5L5Y_J.1
5L5Y_X.1
5L5Z_J.1
5L5Z_X.1
5L60_J.1
5L60_X.1
5L61_J.1
5L61_X.1
5L62_J.1
5L62_X.1
5L63_J.1
5L63_X.1
5L64_J.1
5L64_X.1
5L65_J.1
5L65_X.1
5L66_J.1
5L66_X.1
5L67_J.1
5L67_X.1
5L68_J.1
5L68_X.1
5L69_J.1
5L69_X.1
5L6A_J.1
5L6A_X.1
5L6B_J.1
5L6B_X.1
5L6C_J.1
5L6C_X.1
5LAI_J.1
5LAI_X.1
5LAJ_J.1
5LAJ_X.1
5LTT_J.1
5LTT_X.1
5M2B_J.1
5M2B_X.1
5MP9_4.1
5MP9_k.1
5MPA_4.1
5MPA_k.1
5MPB_4.1
5MPB_k.1
5MPC_4.1
5MPC_k.1
5NIF_K.1
5NIF_Y.1
5WVI_4.1
5WVI_g.1
5WVK_4.1
5WVK_g.1
6EF3_4.1
6G7F_J.1
6G7F_X.1
6G8M_J.1
6G8M_X.1
6G8N_J.1
6G8N_X.1
6GOP_J.1
6GOP_X.1
6H39_J.1
6H39_X.1
6HTB_J.1
6HTB_X.1
6HTC_J.1
6HTC_X.1
6HTD_J.1
6HTD_X.1
6HTP_J.1
6HTP_X.1
6HTR_J.1
6HTR_X.1
6HUB_J.1
6HUB_X.1
6HUC_J.1
6HUC_X.1
6HUQ_J.1
6HUQ_X.1
6HUU_J.1
6HUU_X.1
6HUV_J.1
6HUV_X.1
6HV3_J.1
6HV3_X.1
6HV4_J.1
6HV4_X.1
6HV5_J.1
6HV5_X.1
6HV7_J.1
6HV7_X.1
6HVA_J.1
6HVA_X.1
6HVR_J.1
6HVR_X.1
6HVS_J.1
6HVS_X.1
6HVT_J.1
6HVT_X.1
6HVU_J.1
6HVU_X.1
6HVV_J.1
6HVV_X.1
6HVW_J.1
6HVW_X.1
6HVX_J.1
6HVX_X.1
6HVY_J.1
6HVY_X.1
6HW0_J.1
6HW0_X.1
6HW3_J.1
6HW3_X.1
6HW4_J.1
6HW4_X.1
6HW5_J.1
6HW5_X.1
6HW6_J.1
6HW6_X.1
6HW7_J.1
6HW7_X.1
6HW8_J.1
6HW8_X.1
6HW9_J.1
6HW9_X.1
6HWA_J.1
6HWA_X.1
6HWB_J.1
6HWB_X.1
6HWC_J.1
6HWC_X.1
6HWD_J.1
6HWD_X.1
6HWE_J.1
6HWE_X.1
6HWF_J.1
6HWF_X.1
6J2C_4.1
6J2C_g.1
6J2N_4.1
6J2N_g.1
6J2Q_4.1
6J2Q_g.1
6J2X_4.1
6J2X_g.1
6J30_4.1
6J30_g.1
6ZOU_J.1
6ZOU_X.1
6ZP6_J.1
6ZP6_X.1
6ZP8_J.1
6ZP8_X.1
7LS6_K.1
7LSX_K.1
P22141.2

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