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SPE3 spermidine synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856182, updated on 13-Apr-2024

Summary

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Gene symbol
SPE3
Gene description
spermidine synthase
Primary source
SGD:S000006273
Locus tag
YPR069C
See related
AllianceGenome:SGD:S000006273
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables spermidine synthase activity. Involved in pantothenate biosynthetic process and spermidine biosynthetic process. Located in cytoplasm and nucleus. Orthologous to human SRM (spermidine synthase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (684556..685437, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Isa2p Neighboring gene histone deacetylase Neighboring gene Med1p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Over-expression of the apple spermidine synthase gene in pear confers multiple abiotic stress tolerance by altering polyamine titers. Wen XP, et al. Transgenic Res, 2008 Apr. PMID 17549601
  2. Spermidine biosynthesis in Saccharomyces cerevisae: polyamine requirement of a null mutant of the SPE3 gene (spermidine synthase). Hamasaki-Katagiri N, et al. Gene, 1997 Mar 10. PMID 9073064
  3. Formation of cadaverine derivatives in Saccharomyces cerevisiae. Walters DR, et al. FEMS Microbiol Lett, 1996 Dec 1. PMID 8961564
  4. Overexpression of yeast spermidine synthase impacts ripening, senescence and decay symptoms in tomato. Nambeesan S, et al. Plant J, 2010 Sep. PMID 20584149
  5. Microarray studies on the genes responsive to the addition of spermidine or spermine to a Saccharomyces cerevisiae spermidine synthase mutant. Chattopadhyay MK, et al. Yeast, 2009 Oct. PMID 19688718, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables spermidine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables spermidine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables spermidine synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in pantothenate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in polyamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in spermidine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermidine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in spermidine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
spermidine synthase
NP_015394.1
  • Spermidine synthase; involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    684556..685437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184166.1 → NP_015394.1  TPA: spermidine synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015394.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W473, Q12074
    UniProtKB/TrEMBL
    A0A6A5Q1I6, A6ZWV6, B3LLC2, B5VTL6, C7GY53, C8ZJ94, G2WPP1, N1NXL5
    Conserved Domains (1) summary
    TIGR00417
    Location:14 → 287
    speE; spermidine synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12074.1

Gene LinkOut

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