MVD1 diphosphomevalonate decarboxylase MVD1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: MVD1
Gene description: diphosphomevalonate decarboxylase MVD1
Primary source: SGD:S000005326
Locus tag: YNR043W
See related: AllianceGenome:SGD:S000005326
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ERG19
Summary: Enables diphosphomevalonate decarboxylase activity. Involved in sterol biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human MVD (mevalonate diphosphate decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (701895..703085)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors report that the Saccharomyces cerevisiae mevalonate diphosphate decarboxylase (ScMDD) can convert 3-hydroxy-3-methylbutyrate (3-HMB) to isobutene.
Title: Formation of isobutene from 3-hydroxy-3-methylbutyrate by diphosphomevalonate decarboxylase.
The active site of Saccharomyces cerevisiae MVD (scMVD) was elucidated using a molecular docking and simulation-based approach.
Title: Simulation of structural and functional properties of mevalonate diphosphate decarboxylase (MVD).
While serine-34 and serine-208 are either invariant or highly conserved in sequences proposed to correspond to yeast mevalonate diphosphate decarboxylases, replacement of these residues with alanine leads to unstable proteins.
Title: Investigation of the functional contributions of invariant serine residues in yeast mevalonate diphosphate decarboxylase.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables diphosphomevalonate decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables diphosphomevalonate decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables diphosphomevalonate decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables diphosphomevalonate decarboxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ergosterol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway	IEA Inferred from Electronic Annotation more info
involved_in isoprenoid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in sterol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in sterol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in vacuole	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: diphosphomevalonate decarboxylase MVD1

NP_014441.1

EC 4.1.1.33

Mevalonate pyrophosphate decarboxylase; essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

701895..703085

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183220.1 → NP_014441.1 TPA: diphosphomevalonate decarboxylase MVD1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014441.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1L8, P32377, Q6B1C8

UniProtKB/TrEMBL

A0A8H4BY34, B3LPK0, C8ZFS2, N1P4U1

Conserved Domains (1) summary

TIGR01240
Location:6 → 328

mevDPdecarb; diphosphomevalonate decarboxylase