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PRE5 proteasome core particle subunit alpha 6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855362, updated on 5-May-2024

Summary

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Gene symbol
PRE5
Gene description
proteasome core particle subunit alpha 6
Primary source
SGD:S000004931
Locus tag
YMR314W
See related
AllianceGenome:SGD:S000004931
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in proteasomal ubiquitin-independent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in proteasome storage granule. Part of proteasome core complex, alpha-subunit complex. Used to study cancer. Orthologous to human PSMA1 (proteasome 20S subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (901709..902413)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Elongator subunit ELP6 Neighboring gene bifunctional triglyceride lipase/lysophosphatidylethanolamine acyltransferase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PRE5 and PRE6, the last missing genes encoding 20S proteasome subunits from yeast? Indication for a set of 14 different subunits in the eukaryotic proteasome core. Heinemeyer W, et al. Biochemistry, 1994 Oct 11. PMID 7918444
  2. The N-terminal methionine of cellular proteins as a degradation signal. Kim HK, et al. Cell, 2014 Jan 16. PMID 24361105, Free PMC Article
  3. Transcriptional regulation of protein complexes within and across species. Tan K, et al. Proc Natl Acad Sci U S A, 2007 Jan 23. PMID 17227853, Free PMC Article
  4. The pore of activated 20S proteasomes has an ordered 7-fold symmetric conformation. Förster A, et al. EMBO J, 2003 Sep 1. PMID 12941688, Free PMC Article
  5. N-terminal α7 deletion of the proteasome 20S core particle substitutes for yeast PI31 function. Yashiroda H, et al. Mol Cell Biol, 2015 Jan. PMID 25332237, Free PMC Article

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that the dynamic gate can be opened by allosteric coupling to a tetrahedral transition state at any of the working active centers of proteasome.
    Title: A tetrahedral transition state at the active sites of the 20S proteasome is coupled to opening of the alpha-ring channel.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in proteasomal ubiquitin-independent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteasomal ubiquitin-independent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome core complex, alpha-subunit complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome core complex, alpha-subunit complex IEA
Inferred from Electronic Annotation
more info
  
located_in proteasome storage granule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
proteasome core particle subunit alpha 6
NP_014045.1
  • Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    901709..902413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182825.1 → NP_014045.1  TPA: proteasome core particle subunit alpha 6 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014045.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0E1, P40302
    UniProtKB/TrEMBL
    A0A6A5PTH4, A6ZN31, B3LMK2, B5VQ80, C7GPU9, C8ZFI5, G2WL23, N1P645
    Conserved Domains (1) summary
    cl00467
    Location:6 → 217
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
3JCO_F.1
3JCO_f.1
3JCP_F.1
3JCP_f.1
3UN4_E.1
3UN4_S.1
3UN8_E.1
3UN8_S.1
3WXR_F.1
3WXR_T.1
4JSQ_E.1
4JSQ_S.1
4JSU_E.1
4JSU_S.1
4JT0_E.1
4JT0_S.1
4LTC_E.1
4LTC_S.1
4NNN_E.1
4NNN_S.1
4NNW_E.1
4NNW_S.1
4NO1_E.1
4NO1_S.1
4NO6_E.1
4NO6_S.1
4NO8_E.1
4NO8_S.1
4NO9_E.1
4NO9_S.1
4Q1S_E.1
4Q1S_S.1
4QBY_E.1
4QBY_S.1
4QLQ_E.1
4QLQ_S.1
4QLS_E.1
4QLS_S.1
4QLT_E.1
4QLT_S.1
4QLU_E.1
4QLU_S.1
4QLV_E.1
4QLV_S.1
4QUX_E.1
4QUX_S.1
4QUY_E.1
4QUY_S.1
4QV0_E.1
4QV0_S.1
4QV1_E.1
4QV1_S.1
4QV3_E.1
4QV3_S.1
4QV4_E.1
4QV4_S.1
4QV5_E.1
4QV5_S.1
4QV6_E.1
4QV6_S.1
4QV7_E.1
4QV7_S.1
4QV8_E.1
4QV8_S.1
4QV9_E.1
4QV9_S.1
4QVL_E.1
4QVL_S.1
4QVM_E.1
4QVM_S.1
4QVN_E.1
4QVN_S.1
4QVP_E.1
4QVP_S.1
4QVQ_E.1
4QVQ_S.1
4QVV_E.1
4QVV_S.1
4QVW_E.1
4QVW_S.1
4QVY_E.1
4QVY_S.1
4QW0_E.1
4QW0_S.1
4QW1_E.1
4QW1_S.1
4QW3_E.1
4QW3_S.1
4QW4_E.1
4QW4_S.1
4QW5_E.1
4QW5_S.1
4QW6_E.1
4QW6_S.1
4QW7_E.1
4QW7_S.1
4QWF_E.1
4QWF_S.1
4QWG_E.1
4QWG_S.1
4QWI_E.1
4QWI_S.1
4QWJ_E.1
4QWJ_S.1
4QWK_E.1
4QWK_S.1
4QWL_E.1
4QWL_S.1
4QWR_E.1
4QWR_S.1
4QWS_E.1
4QWS_S.1
4QWU_E.1
4QWU_S.1
4QWX_E.1
4QWX_S.1
4QXJ_E.1
4QXJ_S.1
4QZ0_E.1
4QZ0_S.1
4QZ1_E.1
4QZ1_S.1
4QZ2_E.1
4QZ2_S.1
4QZ3_E.1
4QZ3_S.1
4QZ4_E.1
4QZ4_S.1
4QZ5_E.1
4QZ5_S.1
4QZ6_E.1
4QZ6_S.1
4QZ7_E.1
4QZ7_S.1
4QZW_E.1
4QZW_S.1
4QZX_E.1
4QZX_S.1
4QZZ_E.1
4QZZ_S.1
4R00_E.1
4R00_S.1
4R02_E.1
4R02_S.1
4R17_E.1
4R17_S.1
4R18_E.1
4R18_S.1
4RUR_E.1
4RUR_S.1
4X6Z_F.1
4X6Z_T.1
4Y69_E.1
4Y69_S.1
4Y6A_E.1
4Y6A_S.1
4Y6V_E.1
4Y6V_S.1
4Y6Z_E.1
4Y6Z_S.1
4Y70_E.1
4Y70_S.1
4Y74_E.1
4Y74_S.1
4Y75_E.1
4Y75_S.1
4Y77_E.1
4Y77_S.1
4Y78_E.1
4Y78_S.1
4Y7W_E.1
4Y7W_S.1
4Y7X_E.1
4Y7X_S.1
4Y7Y_E.1
4Y7Y_S.1
4Y80_E.1
4Y80_S.1
4Y81_E.1
4Y81_S.1
4Y82_E.1
4Y82_S.1
4Y84_E.1
4Y84_S.1
4Y8G_E.1
4Y8G_S.1
4Y8H_E.1
4Y8H_S.1
4Y8I_E.1
4Y8I_S.1
4Y8J_E.1
4Y8J_S.1
4Y8K_E.1
4Y8K_S.1
4Y8L_E.1
4Y8L_S.1
4Y8M_E.1
4Y8M_S.1
4Y8N_E.1
4Y8N_S.1
4Y8O_E.1
4Y8O_S.1
4Y8P_E.1
4Y8P_S.1
4Y8Q_E.1
4Y8Q_S.1
4Y8R_E.1
4Y8R_S.1
4Y8S_E.1
4Y8S_S.1
4Y8T_E.1
4Y8T_S.1
4Y8U_E.1
4Y8U_S.1
4Y9Y_E.1
4Y9Y_S.1
4Y9Z_E.1
4Y9Z_S.1
4YA0_E.1
4YA0_S.1
4YA1_E.1
4YA1_S.1
4YA2_E.1
4YA2_S.1
4YA3_E.1
4YA3_S.1
4YA4_E.1
4YA4_S.1
4YA5_E.1
4YA5_S.1
4YA7_E.1
4YA7_S.1
4YA9_E.1
4YA9_S.1
4Z1L_E.1
4Z1L_S.1
5BOU_E.1
5BOU_S.1
5BXL_E.1
5BXL_S.1
5BXN_E.1
5BXN_S.1
5CGF_E.1
5CGF_S.1
5CGG_E.1
5CGG_S.1
5CGH_E.1
5CGH_S.1
5CGI_E.1
5CGI_S.1
5CZ4_E.1
5CZ4_S.1
5CZ5_E.1
5CZ5_S.1
5CZ6_E.1
5CZ6_S.1
5CZ7_E.1
5CZ7_S.1
5CZ8_E.1
5CZ8_S.1
5CZ9_E.1
5CZ9_S.1
5CZA_E.1
5CZA_S.1
5D0S_E.1
5D0S_S.1
5D0T_E.1
5D0T_S.1
5D0V_E.1
5D0V_S.1
5D0W_E.1
5D0W_S.1
5D0X_E.1
5D0X_S.1
5D0Z_E.1
5D0Z_S.1
5DKI_E.1
5DKI_S.1
5DKJ_E.1
5DKJ_S.1
5FG7_E.1
5FG7_S.1
5FG9_E.1
5FG9_S.1
5FGA_E.1
5FGA_S.1
5FGD_E.1
5FGD_S.1
5FGE_E.1
5FGE_S.1
5FGF_E.1
5FGF_S.1
5FGG_E.1
5FGG_S.1
5FGH_E.1
5FGH_S.1
5FGI_E.1
5FGI_S.1
5FHS_E.1
5FHS_S.1
5JHR_E.1
5JHR_S.1
5JHS_E.1
5JHS_S.1
5L52_E.1
5L52_S.1
5L54_E.1
5L54_S.1
5L55_E.1
5L55_S.1
5L5A_E.1
5L5A_S.1
5L5B_E.1
5L5B_S.1
5L5D_E.1
5L5D_S.1
5L5E_E.1
5L5E_S.1
5L5F_E.1
5L5F_S.1
5L5H_E.1
5L5H_S.1
5L5I_E.1
5L5I_S.1
5L5J_E.1
5L5J_S.1
5L5O_E.1
5L5O_S.1
5L5P_E.1
5L5P_S.1
5L5Q_E.1
5L5Q_S.1
5L5R_E.1
5L5R_S.1
5L5S_E.1
5L5S_S.1
5L5T_E.1
5L5T_S.1
5L5U_E.1
5L5U_S.1
5L5V_E.1
5L5V_S.1
5L5W_E.1
5L5W_S.1
5L5X_E.1
5L5X_S.1
5L5Y_E.1
5L5Y_S.1
5L5Z_E.1
5L5Z_S.1
5L60_E.1
5L60_S.1
5L61_E.1
5L61_S.1
5L62_E.1
5L62_S.1
5L63_E.1
5L63_S.1
5L64_E.1
5L64_S.1
5L65_E.1
5L65_S.1
5L66_E.1
5L66_S.1
5L67_E.1
5L67_S.1
5L68_E.1
5L68_S.1
5L69_E.1
5L69_S.1
5L6A_E.1
5L6A_S.1
5L6B_E.1
5L6B_S.1
5L6C_E.1
5L6C_S.1
5LAI_E.1
5LAI_S.1
5LAJ_E.1
5LAJ_S.1
5LTT_E.1
5LTT_S.1
5M2B_E.1
5M2B_S.1
5MP9_F.1
5MP9_f.1
5MPA_F.1
5MPA_f.1
5MPB_F.1
5MPB_f.1
5MPC_F.1
5MPC_f.1
5NIF_F.1
5NIF_T.1
5WVI_F.1
5WVI_l.1
5WVK_F.1
5WVK_l.1
6EF0_F.1
6EF3_F.1
6G7F_E.1
6G7F_S.1
6G8M_E.1
6G8M_S.1
6G8N_E.1
6G8N_S.1
6GOP_E.1
6GOP_S.1
6H39_E.1
6H39_S.1
6HTB_E.1
6HTB_S.1
6HTC_E.1
6HTC_S.1
6HTD_E.1
6HTD_S.1
6HTP_E.1
6HTP_S.1
6HTR_E.1
6HTR_S.1
6HUB_E.1
6HUB_S.1
6HUC_E.1
6HUC_S.1
6HUQ_E.1
6HUQ_S.1
6HUU_E.1
6HUU_S.1
6HUV_E.1
6HUV_S.1
6HV3_E.1
6HV3_S.1
6HV4_E.1
6HV4_S.1
6HV5_E.1
6HV5_S.1
6HV7_E.1
6HV7_S.1
6HVA_E.1
6HVA_S.1
6HVR_E.1
6HVR_S.1
6HVS_E.1
6HVS_S.1
6HVT_E.1
6HVT_S.1
6HVU_E.1
6HVU_S.1
6HVV_E.1
6HVV_S.1
6HVW_E.1
6HVW_S.1
6HVX_E.1
6HVX_S.1
6HVY_E.1
6HVY_S.1
6HW0_E.1
6HW0_S.1
6HW3_E.1
6HW3_S.1
6HW4_E.1
6HW4_S.1
6HW5_E.1
6HW5_S.1
6HW6_E.1
6HW6_S.1
6HW7_E.1
6HW7_S.1
6HW8_E.1
6HW8_S.1
6HW9_E.1
6HW9_S.1
6HWA_E.1
6HWA_S.1
6HWB_E.1
6HWB_S.1
6HWC_E.1
6HWC_S.1
6HWD_E.1
6HWD_S.1
6HWE_E.1
6HWE_S.1
6HWF_E.1
6HWF_S.1
6J2C_F.1
6J2C_l.1
6J2N_F.1
6J2N_l.1
6J2Q_F.1
6J2Q_l.1
6J2X_F.1
6J2X_l.1
6J30_F.1
6J30_l.1
6ZOU_E.1
6ZOU_S.1
6ZP6_E.1
6ZP6_S.1
6ZP8_E.1
6ZP8_S.1
7LS5_F.1
7LS5_T.1
7LS6_F.1
7LSX_F.1
P40302.1

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