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ERG12 mevalonate kinase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855248, updated on 13-Apr-2024

Summary

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Gene symbol
ERG12
Gene description
mevalonate kinase
Primary source
SGD:S000004821
Locus tag
YMR208W
See related
AllianceGenome:SGD:S000004821
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RAR1
Summary
Enables mevalonate kinase activity. Involved in ergosterol biosynthetic process; farnesyl diphosphate biosynthetic process, mevalonate pathway; and isopentenyl diphosphate biosynthetic process, mevalonate pathway. Located in cytosol and nucleus. Used to study cancer and mevalonic aciduria. Human ortholog(s) of this gene implicated in lipid metabolism disorder; mevalonic aciduria; and porokeratosis. Orthologous to human MVK (mevalonate kinase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (684467..685798)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene acetyl-CoA carboxylase HFA1 Neighboring gene uncharacterized protein Neighboring gene putative carboxylic ester hydrolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Incomplete mitophagy in the mevalonate kinase-deficient Saccharomyces cerevisiae and its relation to the MKD-related autoinflammatory disease in humans. Santos MMS, et al. Biochim Biophys Acta Mol Basis Dis, 2021 Apr 1. PMID 33385519, Free PMC Article
  2. Reduction of background interference in the spectrophotometric assay of mevalonate kinase. Song L. Anal Bioanal Chem, 2006 Mar. PMID 16477420
  3. Mutations that increase the mitotic stability of minichromosomes in yeast: characterization of RAR1. Kearsey SE, et al. Mol Gen Genet, 1987 Dec. PMID 3323847
  4. Isolation of the ERG12 gene of Saccharomyces cerevisiae encoding mevalonate kinase. Oulmouden A, et al. Gene, 1990 Apr 16. PMID 2161381
  5. Nucleotide sequence of the ERG12 gene of Saccharomyces cerevisiae encoding mevalonate kinase. Oulmouden A, et al. Curr Genet, 1991 Jan. PMID 1645230

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Incomplete mitophagy in the mevalonate kinase-deficient Saccharomyces cerevisiae and its relation to the MKD-related autoinflammatory disease in humans.
    Title: Incomplete mitophagy in the mevalonate kinase-deficient Saccharomyces cerevisiae and its relation to the MKD-related autoinflammatory disease in humans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables mevalonate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mevalonate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mevalonate kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ergosterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ergosterol biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ergosterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
mevalonate kinase
NP_013935.1
  • Mevalonate kinase; acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate; human MVK functionally complements the lethality of the erg12 null mutation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    684467..685798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182715.1 → NP_013935.1  TPA: mevalonate kinase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013935.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W033, P07277
    UniProtKB/TrEMBL
    A0A8H4FBB8, A6ZMS0, C7GRE3, C8ZF73, G2WKR4, N1P5T7
    Conserved Domains (1) summary
    TIGR00549
    Location:9 → 361
    mevalon_kin; mevalonate kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07277.1

Gene LinkOut

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