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NAS2 Nas2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854810, updated on 13-Apr-2024

Summary

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Gene symbol
NAS2
Gene description
Nas2p
Primary source
SGD:S000001269
Locus tag
YIL007C
See related
AllianceGenome:SGD:S000001269
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in proteasome regulatory particle assembly. Located in cytosol and nucleus. Orthologous to human PSMD9 (proteasome 26S subunit, non-ATPase 9). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (342994..343656, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene long-chain fatty acid-CoA ligase FAA3 Neighboring gene ubiquitin-related modifier URM1 Neighboring gene NAD+ transporter Neighboring gene protein disulfide isomerase EPS1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. 1.15 Å resolution structure of the proteasome-assembly chaperone Nas2 PDZ domain. Singh CR, et al. Acta Crystallogr F Struct Biol Commun, 2014 Apr. PMID 24699731, Free PMC Article
  2. cDNA cloning and characterization of a human proteasomal modulator subunit, p27 (PSMD9). Watanabe TK, et al. Genomics, 1998 Jun 1. PMID 9653651
  3. Tagging the proteasome active site β5 causes tag specific phenotypes in yeast. Waite KA, et al. Sci Rep, 2020 Oct 22. PMID 33093623, Free PMC Article
  4. Mitochondria-Associated Degradation Pathway (MAD) Function beyond the Outer Membrane. Liao PC, et al. Cell Rep, 2020 Jul 14. PMID 32668258, Free PMC Article
  5. Two alternative mechanisms regulate the onset of chaperone-mediated assembly of the proteasomal ATPases. Nahar A, et al. J Biol Chem, 2019 Apr 19. PMID 30814255, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of Rpt5 protein interactions with the core particle and Nas2 protein causes the formation of faulty proteasomes that are inhibited by Ecm29 protein.
    Title: Loss of Rpt5 protein interactions with the core particle and Nas2 protein causes the formation of faulty proteasomes that are inhibited by Ecm29 protein.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in proteasome regulatory particle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome regulatory particle assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteasome regulatory particle assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome regulatory particle assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in proteasome regulatory particle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Nas2p
NP_012259.3
  • Evolutionarily conserved 19S regulatory particle assembly-chaperone; involved in assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress; ortholog of human p27

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    342994..343656 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179357.3 → NP_012259.3  TPA: Nas2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012259.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVS3, P40555
    UniProtKB/TrEMBL
    A0A8H4BZ97, A6ZVR1, B3LTL6, B5VKT0, C7GJH8, G2WGD9, N1P294
    Conserved Domains (2) summary
    pfam00595
    Location:106 → 182
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam18265
    Location:31 → 109
    Nas2_N; Nas2 N_terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40555.1

Gene LinkOut

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