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SSL2 TFIIH/NER complex ATPase/helicase subunit SSL2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854663, updated on 13-Apr-2024

Summary

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Gene symbol
SSL2
Gene description
TFIIH/NER complex ATPase/helicase subunit SSL2
Primary source
SGD:S000001405
Locus tag
YIL143C
See related
AllianceGenome:SGD:S000001405
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LOM3; RAD25
Summary
Enables DNA helicase activity and DNA translocase activity. Involved in several processes, including poly(A)+ mRNA export from nucleus; regulation of nucleobase-containing compound metabolic process; and transcription by RNA polymerase II. Located in cytosol and nucleus. Part of RNA polymerase II transcription regulator complex; nucleotide-excision repair factor 3 complex; and transcription preinitiation complex. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; photosensitive trichothiodystrophy 2; trichothiodystrophy; xeroderma pigmentosum; and xeroderma pigmentosum group B. Orthologous to human ERCC3 (ERCC excision repair 3, TFIIH core complex helicase subunit). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (80510..83041, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene pantoate--beta-alanine ligase PAN6 Neighboring gene kinetochore-associated Ndc80 complex subunit NDC80 Neighboring gene chaperonin-containing T-complex subunit CCT2 Neighboring gene Axl2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Double-stranded DNA translocase activity of transcription factor TFIIH and the mechanism of RNA polymerase II open complex formation. Fishburn J, et al. Proc Natl Acad Sci U S A, 2015 Mar 31. PMID 25775526, Free PMC Article
  2. Functions of yeast helicase Ssl2p that are essential for viability are also involved in protection from the toxicity of adriamycin. Furuchi T, et al. Nucleic Acids Res, 2004. PMID 15141027, Free PMC Article
  3. Overexpression of Ssl2p confers resistance to adriamycin and actinomycin D in Saccharomyces cerevisiae. Furuchi T, et al. Biochem Biophys Res Commun, 2004 Feb 13. PMID 14741713
  4. The participation of AtXPB1, the XPB/RAD25 homologue gene from Arabidopsis thaliana, in DNA repair and plant development. Costa RM, et al. Plant J, 2001 Nov. PMID 11737776
  5. Rad25p, a DNA helicase subunit of yeast transcription factor TFIIH, is required for promoter escape in vivo. Ostapenko D, et al. Gene, 2000 Mar 7. PMID 10713451

See all (97) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ssl2/TFIIH function in transcription start site scanning by RNA polymerase II in Saccharomyces cerevisiae.
    Title: Ssl2/TFIIH function in transcription start site scanning by RNA polymerase II in Saccharomyces cerevisiae.
  2. Rad25 turnover requires the ubiquitin-conjugating enzyme Ubc4 and the ubiquitin ligase Ufd4.
    Title: Rad25 protein is targeted for degradation by the Ubc4-Ufd4 pathway.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA translocase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA polymerase II promoter clearance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleotide-excision repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
  
involved_in poly(A)+ mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription initiation at RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription initiation at RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription open complex formation at RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcriptional start site selection at RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nucleotide-excision repair factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleotide-excision repair factor 3 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIH core complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIIH holo complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIH holo complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription preinitiation complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
TFIIH/NER complex ATPase/helicase subunit SSL2
NP_012123.1
  • Component of RNA polymerase transcription factor TFIIH holoenzyme; acts as dsDNA-dependent translocase in context of TFIIH, unwinds DNA strands during initiation and promotes transcription start site (TSS) scanning; has DNA-dependent ATPase/helicase activity; interacts functionally with TFIIB, has roles in TSS selection and gene looping to juxtapose initiation and termination regions; involved in DNA repair; relocalizes to cytosol under hypoxia; homolog of human ERCC3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    80510..83041 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179491.1 → NP_012123.1  TPA: TFIIH/NER complex ATPase/helicase subunit SSL2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012123.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVE4, Q00578
    UniProtKB/TrEMBL
    A0A8H4BZ12, A6ZVD3, B3LTZ0, C7GUR0, G2WG09, N1P0T0
    Conserved Domains (1) summary
    TIGR00603
    Location:117 → 835
    rad25; DNA repair helicase rad25
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
7K01_7.1
7K04_7.1
7M2U_7.1
7O4I_7.1
7O4J_7.1
7O4K_7.1
7O4L_7.1
7O72_7.1
7O73_7.1
7O75_7.1
Q00578.1

Gene LinkOut

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