GDH1 glutamate dehydrogenase (NADP(+)) GDH1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: GDH1
Gene description: glutamate dehydrogenase (NADP(+)) GDH1
Primary source: SGD:S000005902
Locus tag: YOR375C
See related: AllianceGenome:SGD:S000005902
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: DHE4; URE1
Summary: Enables glutamate dehydrogenase (NADP+) activity. Involved in glutamate biosynthetic process. Located in nucleus. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 6; hyperinsulinism; hypoglycemia; and late onset Parkinson's disease. Orthologous to human GLUD1 (glutamate dehydrogenase 1) and GLUD2 (glutamate dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Glucose starvation triggered the transition of the soluble form of Gdh1 into the insoluble aggregate form.
Title: The NADP(+)-dependent glutamate dehydrogenase Gdh1 is subjected to glucose starvation-induced reversible aggregation that affects stress resistance in yeast.
The role of glutamate dehydrogenase 1 (Gdh1) in the regulation of telomeric silencing.
Title: Functions for diverse metabolic activities in heterochromatin.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables glutamate dehydrogenase (NADP+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate dehydrogenase (NADP+) activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables glutamate dehydrogenase (NADP+) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glutamate dehydrogenase [NAD(P)+] activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glutamate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutamate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

NP_015020.3

NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication