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RPA190 DNA-directed RNA polymerase I core subunit RPA190 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854519, updated on 13-Apr-2024

Summary

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Gene symbol
RPA190
Gene description
DNA-directed RNA polymerase I core subunit RPA190
Primary source
SGD:S000005868
Locus tag
YOR341W
See related
AllianceGenome:SGD:S000005868
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RRN1
Summary
Enables promoter-specific chromatin binding activity. Contributes to RNA polymerase I activity. Involved in nucleolar large rRNA transcription by RNA polymerase I. Located in nucleolus. Part of RNA polymerase I complex. Human ortholog(s) of this gene implicated in acrofacial dysostosis Cincinnati type. Orthologous to human POLR1A (RNA polymerase I subunit A). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (960987..965981)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene putative E2 ubiquitin-protein ligase UBC11 Neighboring gene DNA-directed RNA polymerase I subunit RPA43 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In yeast cells arrested at the early S-phase by hydroxyurea, rRNA gene promoters and chromatin are poised for transcription while rRNA synthesis is compromised. Charton R, et al. Mutat Res, 2019 May. PMID 31063901
  2. Isolation and characterization of temperature-sensitive mutations in RPA190, the gene encoding the largest subunit of RNA polymerase I from Saccharomyces cerevisiae. Wittekind M, et al. Mol Cell Biol, 1988 Oct. PMID 3054507, Free PMC Article
  3. Conditional expression of RPA190, the gene encoding the largest subunit of yeast RNA polymerase I: effects of decreased rRNA synthesis on ribosomal protein synthesis. Wittekind M, et al. Mol Cell Biol, 1990 May. PMID 2183018, Free PMC Article
  4. Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint. Wei T, et al. Cell Rep, 2018 Apr 10. PMID 29642000, Free PMC Article
  5. Cross talk between tRNA and rRNA synthesis in Saccharomyces cerevisiae. Briand JF, et al. Mol Cell Biol, 2001 Jan. PMID 11113194, Free PMC Article

See all (156) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to RNA polymerase I activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleolar large rRNA transcription by RNA polymerase I IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nucleolar large rRNA transcription by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase I IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase I complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA polymerase I complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA-directed RNA polymerase I core subunit RPA190
NP_014986.3
  • RNA polymerase I largest subunit A190

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    960987..965981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183761.3 → NP_014986.3  TPA: DNA-directed RNA polymerase I core subunit RPA190 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014986.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W336, P10964, Q99330
    UniProtKB/TrEMBL
    A0A7I9C4M8, A6ZPH1, C7GNS5, C8ZH93, G2WNK3, N1P3V0
    Conserved Domains (2) summary
    cd01435
    Location:16 → 1035
    RNAP_I_RPA1_N; Largest subunit (RPA1) of eukaryotic RNA polymerase I (RNAP I), N-terminal domain
    pfam04998
    Location:989 → 1611
    RNA_pol_Rpb1_5; RNA polymerase Rpb1, domain 5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
5LMX_A.1
5M3F_A.1
5M3M_A.1
5M5W_A.1
5N60_A.1
5N61_A.1
5OA1_A.1
5W5Y_A.1
5W64_A.1
5W65_A.1
5W66_A.1
6H67_A.1
6H68_A.1
6HKO_A.1
6HLQ_A.1
6HLR_A.1
6HLS_A.1
P10964.2

Gene LinkOut

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