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RFC1 replication factor C subunit 1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854392, updated on 11-Apr-2024

Summary

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Gene symbol
RFC1
Gene description
replication factor C subunit 1
Primary source
SGD:S000005743
Locus tag
YOR217W
See related
AllianceGenome:SGD:S000005743
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CDC44
Summary
Contributes to DNA clamp loader activity. Involved in leading strand elongation; mismatch repair; and mitotic cell cycle. Part of DNA replication factor C complex. Human ortholog(s) of this gene implicated in West Nile fever. Orthologous to human RFC1 (replication factor C subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (749301..751886)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Aim41p Neighboring gene Rud3p Neighboring gene Ste13p Neighboring gene Rcn2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overproduction in Escherichia coli and characterization of yeast replication factor C lacking the ligase homology domain. Gomes XV, et al. J Biol Chem, 2000 May 12. PMID 10799539
  2. The large subunit of replication factor C (Rfc1p/Cdc44p) is required for DNA replication and DNA repair in Saccharomyces cerevisiae. McAlear MA, et al. Genetics, 1996 Jan. PMID 8770585, Free PMC Article
  3. Allele-specific interactions between the yeast RFC1 and RFC5 genes suggest a basis for RFC subunit-subunit interactions. Beckwith W, et al. Mol Gen Genet, 2000 Nov. PMID 11129041
  4. Specific DNA replication mutations affect telomere length in Saccharomyces cerevisiae. Adams AK, et al. Mol Cell Biol, 1996 Sep. PMID 8756617, Free PMC Article
  5. Identification of the fifth subunit of Saccharomyces cerevisiae replication factor C. Gary SL, et al. Nucleic Acids Res, 1995 Dec 25. PMID 8559655, Free PMC Article

See all (109) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DNA polymerase epsilon outcompetes double-stranded DNA for recruiting Ctf18-RFC to the replisome.
    Title: Structural Basis for the Recruitment of Ctf18-RFC to the Replisome.
  2. Data show that ATP binding rates and ATP-dependent conformational changes in replication factor C (RFC) are fast relative to proliferating cell nuclear antigen (PCNA) binding rates.
    Title: Kinetic analysis of PCNA clamp binding and release in the clamp loading reaction catalyzed by Saccharomyces cerevisiae replication factor C.
  3. We show that Pol eta is less accurate than other yeast DNA polym and the accessory proteins have little effect on fidelity when bypassing a TT dimer. Accessory proteins participate in pol eta functions, but they do not suppress UV mutagenesis.
    Title: Effects of accessory proteins on the bypass of a cis-syn thymine-thymine dimer by Saccharomyces cerevisiae DNA polymerase eta.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA clamp loader activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA clamp unloading IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA strand elongation involved in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in leading strand elongation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mismatch repair IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA replication factor C complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of DNA replication factor C complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
replication factor C subunit 1
NP_014860.1
  • Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    749301..751886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183636.1 → NP_014860.1  TPA: replication factor C subunit 1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014860.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2S3, P38630
    UniProtKB/TrEMBL
    A0A8H4BVW3, B3LJP1, C7GWG5, C8ZGX2, N1NYN6
    Conserved Domains (3) summary
    COG5275
    Location:1 → 277
    COG5275; BRCT domain type II [General function prediction only]
    PRK04195
    Location:298 → 762
    PRK04195; replication factor C large subunit; Provisional
    pfam08519
    Location:621 → 776
    RFC1; Replication factor RFC1 C terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38630.1

Gene LinkOut

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