RPB11 DNA-directed RNA polymerase II core subunit RPB11 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: RPB11
Gene description: DNA-directed RNA polymerase II core subunit RPB11
Primary source: SGD:S000005365
Locus tag: YOL005C
See related: AllianceGenome:SGD:S000005365
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to RNA polymerase II activity and RNA-directed 5'-3' RNA polymerase activity. Involved in termination of RNA polymerase II transcription. Part of RNA polymerase II, core complex. Orthologous to several human genes including POLR2J (RNA polymerase II subunit J). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RPB11 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (315813..316175, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An in vitro assay with the tombusvirus replicase indicated that Rpb11p affects TBSV replication and recombination only indirectly, via regulating p33 and p92(pol) levels.
Title: Host transcription factor Rpb11p affects tombusvirus replication and recombination via regulating the accumulation of viral replication proteins.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to RNA polymerase II activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II activity	IEA Inferred from Electronic Annotation more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in RNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in termination of RNA polymerase II transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase II, core complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase II, core complex	IDA Inferred from Direct Assay more info	PubMed
part_of RNA polymerase II, core complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase II, holoenzyme	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA-directed RNA polymerase II core subunit RPB11

NP_014638.1

RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

315813..316175 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183259.1 → NP_014638.1 TPA: DNA-directed RNA polymerase II core subunit RPB11 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014638.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W262, P38902

UniProtKB/TrEMBL

A0A6A5Q7A1, A6ZNK1, B3LJ51, C7GJV7, C8ZHW0, G2WMM6, N1P2V7

Conserved Domains (1) summary

cd06926
Location:13 → 105

RNAP_II_RPB11; RPB11 subunit of Eukaryotic RNA polymerase II

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
3GTM_K.1
3RZD_K.1
3RZO_K.1
3S14_K.1
3S2D_K.1
3S2H_K.1
4X67_K.1
4X6A_K.1
4Y52_K.1
4Y7N_K.1
5C3E_K.1
5C44_K.1
5C4A_K.1
5C4J_K.1
5C4X_K.1
5OQJ_K.1
5OQM_K.1
5OT2_K.1
5U5Q_K.1
5VVR_K.1
5VVS_K.1
5W4U_K.1
5W51_K.1
6BLO_K.1
6BLP_K.1
6BM2_K.1
6BM4_K.1
6BQF_K.1
6GYK_K.1
6GYL_K.1
6GYM_K.1
6I84_K.1
6UPX_K.1
6UPY_K.1
6UPZ_K.1
6UQ0_K.1
6UQ1_K.1
6UQ2_K.1
6UQ3_K.1
7KED_K.1
7KEE_K.1
7KEF_K.1
7O4I_K.1
7O4J_K.1
7O72_K.1
7O73_K.1
7O75_K.1
P38902.1