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RFC4 replication factor C subunit 4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854059, updated on 11-Apr-2024

Summary

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Gene symbol
RFC4
Gene description
replication factor C subunit 4
Primary source
SGD:S000005454
Locus tag
YOL094C
See related
AllianceGenome:SGD:S000005454
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to DNA clamp loader activity. Involved in leading strand elongation and sister chromatid cohesion. Located in cytosol and nucleus. Part of chromosome. Orthologous to human RFC2 (replication factor C subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (141584..142555, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene hexaprenyldihydroxybenzoate methyltransferase Neighboring gene ATP-dependent 3'-5' DNA helicase Neighboring gene tRNA (guanine(9)-N(1))-methyltransferase Neighboring gene cationic amino acid transporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Saccharomyces cerevisiae replication factor C. II. Formation and activity of complexes with the proliferating cell nuclear antigen and with DNA polymerases delta and epsilon. Burgers PM. J Biol Chem, 1991 Nov 25. PMID 1682322
  2. The N- and C-termini of Elg1 contribute to the maintenance of genome stability. Davidson MB, et al. DNA Repair (Amst), 2008 Aug 2. PMID 18482875
  3. Cloning and characterization of the essential Saccharomyces cerevisiae RFC4 gene encoding the 37-kDa subunit of replication factor C. Li X, et al. J Biol Chem, 1994 Aug 26. PMID 8063832
  4. Identification of novel metabolic engineering targets for S-adenosyl-L-methionine production in Saccharomyces cerevisiae via genome-scale engineering. Dong C, et al. Metab Eng, 2021 Jul. PMID 33713797
  5. Rfc4 interacts with Rpa1 and is required for both DNA replication and DNA damage checkpoints in Saccharomyces cerevisiae. Kim HS, et al. Mol Cell Biol, 2001 Jun. PMID 11340166, Free PMC Article

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA clamp loader activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA clamp unloading IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA strand elongation involved in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in leading strand elongation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sister chromatid cohesion IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of Ctf18 RFC-like complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ctf18 RFC-like complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of DNA replication factor C complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DNA replication factor C complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Elg1 RFC-like complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Elg1 RFC-like complex IEA
Inferred from Electronic Annotation
more info
  
part_of Elg1 RFC-like complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of Rad17 RFC-like complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Rad17 RFC-like complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Rad17 RFC-like complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
replication factor C subunit 4
NP_014547.1
  • Subunit of heteropentameric Replication factor C (RF-C); which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; relocalizes to the cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    141584..142555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183348.1 → NP_014547.1  TPA: replication factor C subunit 4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014547.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1X4, P40339
    UniProtKB/TrEMBL
    A0A6A5Q7X4, A6ZNB6, B3LIW9, B5VRG1, C7GRU7, C8ZHM1, G2WME1, N1NXM2
    Conserved Domains (1) summary
    PLN03025
    Location:9 → 323
    PLN03025; replication factor C subunit; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40339.1

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