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GPT2 bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase GPT2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853941, updated on 11-Apr-2024

Summary

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Gene symbol
GPT2
Gene description
bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase GPT2
Primary source
SGD:S000001775
Locus tag
YKR067W
See related
AllianceGenome:SGD:S000001775
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GAT1
Summary
Enables glycerol-3-phosphate O-acyltransferase activity and glycerone-phosphate O-acyltransferase activity. Involved in phospholipid biosynthetic process and regulation of triglyceride metabolic process. Located in endoplasmic reticulum and lipid droplet. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See GPT2 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (567918..570149)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Pam17p Neighboring gene cytochrome-c peroxidase Neighboring gene TRAPP complex core subunit BET3 Neighboring gene uroporphyrinogen-III C-methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Topology of the microsomal glycerol-3-phosphate acyltransferase Gpt2p/Gat1p of Saccharomyces cerevisiae. Pagac M, et al. Mol Microbiol, 2012 Dec. PMID 23016825
  2. Recruiting a new substrate for triacylglycerol synthesis in plants: the monoacylglycerol acyltransferase pathway. Petrie JR, et al. PLoS One, 2012. PMID 22523576, Free PMC Article
  3. Controlling lipid fluxes at glycerol-3-phosphate acyltransferase step in yeast: unique contribution of Gat1p to oleic acid-induced lipid particle formation. Marr N, et al. J Biol Chem, 2012 Mar 23. PMID 22267742, Free PMC Article
  4. Glycerol-3-phosphate acyltransferases gat1p and gat2p are microsomal phosphoproteins with differential contributions to polarized cell growth. Bratschi MW, et al. Eukaryot Cell, 2009 Aug. PMID 19525420, Free PMC Article
  5. The initial step of the glycerolipid pathway: identification of glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate acyltransferases in Saccharomyces cerevisiae. Zheng Z, et al. J Biol Chem, 2001 Nov 9. PMID 11544256

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the model organism yeast the lipid droplet associated GPAT Gpt2 requires phosphorylation at a conserved motif to prevent a futile triacylglycerol cycle.
    Title: Phosphorylation of the lipid droplet localized glycerol‑3‑phosphate acyltransferase Gpt2 prevents a futile triacylglycerol cycle in yeast.
  2. results argue that motifs I, II and III of Gpt2p are in the lumen of the endoplasmic reticulum (ER) and support the notion that the active site of Gpt2p resides in the ER lumen
    Title: Topology of the microsomal glycerol-3-phosphate acyltransferase Gpt2p/Gat1p of Saccharomyces cerevisiae.
  3. Gat1 and Gat2 localized to both perinuclear and cortical endoplasmic reticula in actively proliferating cells.
    Title: Glycerol-3-phosphate acyltransferases gat1p and gat2p are microsomal phosphoproteins with differential contributions to polarized cell growth.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycerol-3-phosphate O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycerol-3-phosphate O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycerol-3-phosphate O-acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glycerone-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycerone-phosphate O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycerone-phosphate O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of triglyceride metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase GPT2
NP_012993.3
  • Glycerol-3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase; located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    567918..570149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179857.3 → NP_012993.3  TPA: bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase GPT2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012993.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXC8, P36148
    UniProtKB/TrEMBL
    A0A8H4F8X1, A7A027, B3LRE2, C8ZCM9, N1P2R7
    Conserved Domains (1) summary
    cl17185
    Location:45 → 348
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36148.1

Gene LinkOut

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