UBA1 E1 ubiquitin-activating protein UBA1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: UBA1
Gene description: E1 ubiquitin-activating protein UBA1
Primary source: SGD:S000001693
Locus tag: YKL210W
See related: AllianceGenome:SGD:S000001693
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ubiquitin activating enzyme activity. Involved in protein ubiquitination. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in VEXAS syndrome and X-linked spinal muscular atrophy 2. Orthologous to several human genes including UBA1 (ubiquitin like modifier activating enzyme 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (39163..42237)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crystal structure of UBA1 with one ubiquitin, which is bound in its adenylated form to the active adenylation domain of UBA1, and the the second ubiquitin is covalently linked to the active-site cysteine.
Title: Structure of the ubiquitin-activating enzyme loaded with two ubiquitin molecules.
isolation of uba1-204, a temperature-sensitive allele of the essential E1 gene, UBA1
Title: A conditional yeast E1 mutant blocks the ubiquitin-proteasome pathway and reveals a role for ubiquitin conjugates in targeting Rad23 to the proteasome.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin activating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin activating enzyme activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin activating enzyme activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like modifier activating enzyme activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein modification process	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E1 ubiquitin-activating protein UBA1

NP_012712.1

EC 6.2.1.45

Ubiquitin activating enzyme (E1); involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

39163..42237

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179775.1 → NP_012712.1 TPA: E1 ubiquitin-activating protein UBA1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012712.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWZ3, P22515

UniProtKB/TrEMBL

A0A8H4FAB0, N1P0K4

Conserved Domains (1) summary

TIGR01408
Location:13 → 1023

Ube1; ubiquitin-activating enzyme E1