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RFC2 replication factor C subunit 2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853531, updated on 13-Apr-2024

Summary

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Gene symbol
RFC2
Gene description
replication factor C subunit 2
Primary source
SGD:S000003829
Locus tag
YJR068W
See related
AllianceGenome:SGD:S000003829
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to DNA clamp loader activity. Involved in DNA replication checkpoint signaling; leading strand elongation; and sister chromatid cohesion. Located in nucleus. Part of chromosome. Orthologous to human RFC4 (replication factor C subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (567643..568704)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol kinase-related protein kinase TOR1 Neighboring gene Yae1p Neighboring gene nucleoside triphosphate pyrophosphohydrolase HAM1 Neighboring gene deoxyhypusine monooxygenase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The RFC2 gene encoding a subunit of replication factor C of Saccharomyces cerevisiae. Noskov V, et al. Nucleic Acids Res, 1994 May 11. PMID 8202350, Free PMC Article
  2. Rfc4 interacts with Rpa1 and is required for both DNA replication and DNA damage checkpoints in Saccharomyces cerevisiae. Kim HS, et al. Mol Cell Biol, 2001 Jun. PMID 11340166, Free PMC Article
  3. Dominant mutations in three different subunits of replication factor C suppress replication defects in yeast PCNA mutants. Amin NS, et al. Genetics, 1999 Dec. PMID 10581271, Free PMC Article
  4. Eukaryotic DNA mismatch repair. Kolodner RD, et al. Curr Opin Genet Dev, 1999 Feb. PMID 10072354
  5. Functional and physical interaction between Rad24 and Rfc5 in the yeast checkpoint pathways. Shimomura T, et al. Mol Cell Biol, 1998 Sep. PMID 9710632, Free PMC Article

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA clamp loader activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA clamp unloading IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA strand elongation involved in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in leading strand elongation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mismatch repair TAS
Traceable Author Statement
more info
 PubMed 
involved_in sister chromatid cohesion IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of Ctf18 RFC-like complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of DNA replication factor C complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DNA replication factor C complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Elg1 RFC-like complex IEA
Inferred from Electronic Annotation
more info
  
part_of Elg1 RFC-like complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of Rad17 RFC-like complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Rad17 RFC-like complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
replication factor C subunit 2
NP_012602.3
  • Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    567643..568704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181726.3 → NP_012602.3  TPA: replication factor C subunit 2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012602.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWN9, E9P8U1, P40348
    UniProtKB/TrEMBL
    A0A8H4C165, A6ZQ27, C7GMD5, C8ZBL6, G2WH73, N1P1L7
    Conserved Domains (1) summary
    PRK00440
    Location:23 → 353
    rfc; replication factor C small subunit; Reviewed
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40348.1

Gene LinkOut

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