ERG20 bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: ERG20
Gene description: bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase
Primary source: SGD:S000003703
Locus tag: YJL167W
See related: AllianceGenome:SGD:S000003703
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: BOT3; FDS1; FPP1
Summary: Enables dimethylallyltranstransferase activity and geranyltranstransferase activity. Involved in ergosterol biosynthetic process and farnesyl diphosphate biosynthetic process. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human FDPS (farnesyl diphosphate synthase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (105014..106072)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the development of yeast strains carrying the engineered Erg20p, which support efficient isoprenoid production and can be used as a dedicated chassis for diterpene production or biosynthetic pathway elucidation.
Title: Efficient diterpene production in yeast by engineering Erg20p into a geranylgeranyl diphosphate synthase.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables dimethylallyltranstransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dimethylallyltranstransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables dimethylallyltranstransferase activity	IEA Inferred from Electronic Annotation more info
enables geranyltranstransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables geranyltranstransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables geranyltranstransferase activity	IEA Inferred from Electronic Annotation more info
enables isopentenyl-diphosphate delta-isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring alkyl or aryl (other than methyl) groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ergosterol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ergosterol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in farnesyl diphosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in farnesyl diphosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in farnesyl diphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in geranyl diphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in isoprenoid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in isoprenoid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in vacuole	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase

NP_012368.1

EC 2.5.1.1

EC 2.5.1.10

Farnesyl pyrophosphate synthetase; has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

105014..106072

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181600.1 → NP_012368.1 TPA: bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012368.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VW20, P08524, P15495

UniProtKB/TrEMBL

A0A6L0ZH55, A6ZQG5, B3LPV6, B5VL19, C7GRZ5, C8ZB52, G2WGK6

Conserved Domains (1) summary

pfam00348
Location:38 → 305

polyprenyl_synt; Polyprenyl synthetase