ERG26 sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: ERG26
Gene description: sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)
Primary source: SGD:S000002969
Locus tag: YGL001C
See related: AllianceGenome:SGD:S000002969
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum membrane. Used to study cancer. Human ortholog(s) of this gene implicated in CHILD syndrome and CK syndrome. Orthologous to human NSDHL (NAD(P) dependent steroid dehydrogenase-like). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 3-beta-hydroxy-delta5-steroid dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity	IEA Inferred from Electronic Annotation more info
enables 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity	IEA Inferred from Electronic Annotation more info
enables C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity	IBA Inferred from Biological aspect of Ancestor more info
enables C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity	IDA Inferred from Direct Assay more info	PubMed
enables C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity	IEA Inferred from Electronic Annotation more info
enables sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in ergosterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ergosterol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ergosterol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in sterol biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

Preferred Names: sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)

NP_011514.1

C-3 sterol dehydrogenase; catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; human homolog NSDHL implicated in CK syndrome, and can complement yeast null mutant; molecular target of natural product and antifungal compound FR171456

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The following sections contain reference sequences that belong to a specific genome build. Explain