Plg plasminogen [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plgprovided by RGD
Official Full Name: plasminogenprovided by RGD
Primary source: RGD:619893
See related: Ensembl:ENSRNOG00000017223 AllianceGenome:RGD:619893
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ab1-346
Summary: Enables endopeptidase activity and enzyme binding activity. Involved in proteolysis involved in cellular protein catabolic process. Located in extracellular space; intracellular membrane-bounded organelle; and plasma membrane. Human ortholog(s) of this gene implicated in COVID-19; conjunctivitis; myocardial infarction; plasminogen deficiency type I; and thrombophilia. Orthologous to several human genes including PLG (plasminogen). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 8356.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q11

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (50872927..50915406, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (48325186..48367643, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (48521828..48563895, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Proteoform-Resolved Profiling of Plasminogen Activation Reveals Novel Abundant Phosphorylation Site and Primary N-Terminal Cleavage Site.
Title: Proteoform-Resolved Profiling of Plasminogen Activation Reveals Novel Abundant Phosphorylation Site and Primary N-Terminal Cleavage Site.
The presence of active plasmin in urine in hydronephrosis could cause abnormal proteolytic activation of ENaC-gamma and impaired ability to excrete Na via NCC.
Title: Hydronephrosis is associated with elevated plasmin in urine in pediatric patients and rats and changes in NCC and γ-ENaC abundance in rat kidney.
Plasmin cleaved mainly the N-terminal region of alpha-syn and also inhibited the translocation of extracellular alpha-syn into the neighboring cells in addition to the activation of microglia and astrocytes by extracellular alpha-syn.
Title: Proteolytic cleavage of extracellular α-synuclein by plasmin: implications for Parkinson disease.
Angiostatin overexpression was associated with attenuated renal disease progression in a model of chronic kidney injury, likely because of its anti-inflammatory actions.
Title: Angiostatin overexpression is associated with an improvement in chronic kidney injury by an anti-inflammatory mechanism.
Expression of angiostatin in the ischemic tissues after ischemia-reperfusion in diabetes mellitus + cerebral ischemia group increased significantly.
Title: The possible mechanism for impaired angiogenesis after transient focal ischemia in type 2 diabetic GK rats: different expressions of angiostatin and vascular endothelial growth factor.
Plasmin activates epithelial Na+ channels by cleaving the gamma subunit
Title: Plasmin activates epithelial Na+ channels by cleaving the gamma subunit.
Although plasminogen alone did not evoke prominent neuronal injury, plasminogen caused significant neuronal injury when combined with a moderate concentration of thrombin
Title: Plasminogen potentiates thrombin cytotoxicity and contributes to pathology of intracerebral hemorrhage in rats.
Aprotinin inhibition of the plasmin system was associated with larger thrombi but less vein wall injury, but no difference in other measures of resolution, possibly because of increased vein wall MMP-9 activity
Title: Plasmin inhibition increases MMP-9 activity and decreases vein wall stiffness during venous thrombosis resolution.
plasminogen-related control of hepatocyte proliferation is exerted topically by producing a hyperfibrinolytic state on the cellular surface involving the activation of uPA
Title: Cell surface-bound plasminogen regulates hepatocyte proliferation through a uPA-dependent mechanism.
Plg gene expression is up-regulated by nerve growth factor
Title: Plasminogen gene expression is regulated by nerve growth factor.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Got60 (e-PCR)
- UniSTS:111893

D1Got55 (e-PCR)
- UniSTS:112683

Plg (e-PCR), detects polymorphism
- UniSTS:144222

UniSTS:498273 (e-PCR)
- UniSTS:498273

Plg (e-PCR), detects polymorphism
- UniSTS:498273

RH128566 (e-PCR)
- UniSTS:211874

RH131691 (e-PCR)
- UniSTS:214974

D1Bda1 (e-PCR)
- UniSTS:240335

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables apolipoprotein binding	ISO Inferred from Sequence Orthology more info
enables endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein antigen binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
involved_in fibrinolysis	IEA Inferred from Electronic Annotation more info
involved_in fibrinolysis	ISO Inferred from Sequence Orthology more info
involved_in labyrinthine layer blood vessel development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within labyrinthine layer blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in mononuclear cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mononuclear cell migration	ISO Inferred from Sequence Orthology more info
involved_in muscle cell cellular homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle cell cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in myoblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibrinolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibrinolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis involved in protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in tissue regeneration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tissue regeneration	ISO Inferred from Sequence Orthology more info
involved_in tissue remodeling	IEA Inferred from Electronic Annotation more info
involved_in trans-synaptic signaling by BDNF, modulating synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in trans-synaptic signaling by BDNF, modulating synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in trophoblast giant cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within trophoblast giant cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: plasminogen

NP_445943.1

EC 3.4.21.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053491.2 → NP_445943.1 plasminogen precursor

See identical proteins and their annotated locations for NP_445943.1

Status: PROVISIONAL

Source sequence(s)

BC091135

UniProtKB/Swiss-Prot

Q01177, Q5BKB6, Q9R0W3

UniProtKB/TrEMBL

A0A8I5ZVK5, A6KJY3

Related

ENSRNOP00000023370.3, ENSRNOT00000023368.6

Conserved Domains (4) summary

smart00020
Location:581 → 805

Tryp_SPc; Trypsin-like serine protease

smart00130
Location:374 → 456

KR; Kringle domain

cd00190
Location:582 → 807

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

cd01099
Location:33 → 97

PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...